公开(公告)号：US20110206732A1

公开(公告)日：2011-08-25

申请号：US12673750

申请日：2008-08-19

申请人： Giampiero Pescarmona ,  Antonio Ponzetto ,  Gianfranco Merizzi ,  Luisa Gennero

发明人： Giampiero Pescarmona ,  Antonio Ponzetto ,  Gianfranco Merizzi ,  Luisa Gennero

IPC分类号： A61K39/04 ,  A61K38/38 ,  A61K38/12 ,  A61P35/00

CPC分类号： A61K31/155 ,  A61K38/38

摘要： The present invention relates to albumin as an active ingredient in a medicament for the treatment of cancer and to a pharmaceutical composition comprising at least one anti-neoplastic agent and albumin at a concentration of at least 2% w/v of the composition, in a pharmaceutically acceptable vehicle. The anti-neoplastic agent is preferably hydroxyurea, preferably at concentration between 10 μM and 1 mM, more preferably between 10 μM and 100 μM. The pharmaceutical composition of the invention is effective in the therapeutic treatment of cancer and advantageously shows reduced side effects in comparison with the administration of the anti-neoplastic agent alone.

摘要翻译： 本发明涉及白蛋白作为用于治疗癌症的药物中的活性成分和包含至少一种浓度为组合物至少2％w / v的抗肿瘤剂和白蛋白的药物组合物，其中 药学上可接受的载体。 抗肿瘤剂优选为羟基脲，优选浓度为10μM至1mM，更优选10μM至100μM。 与单独使用抗肿瘤剂相比，本发明的药物组合物在治疗癌症方面是有效的，并且有利地显示减少的副作用。

公开(公告)号：US20110045519A1

公开(公告)日：2011-02-24

申请号：US12521517

申请日：2007-12-21

申请人： Luisa Gennero ,  Antonio Ponzetto ,  Giampiero Pescarmona ,  Andrea Savarino ,  Gianfranco Merizzi

发明人： Luisa Gennero ,  Antonio Ponzetto ,  Giampiero Pescarmona ,  Andrea Savarino ,  Gianfranco Merizzi

IPC分类号： C12N5/071 ,  C12N5/22 ,  C12P21/00 ,  C12Q1/02

CPC分类号： C12N5/067 ,  C12N5/0694 ,  C12N5/16 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/12 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/39 ,  C12N2501/805 ,  C12N2502/11 ,  C12N2502/30

摘要： The invention relates to cell lines from differentiated cells with hepatocytic phenotypes capable of producing albumin and blood coagulation factors, said cells being derived from a human leukaemia cell line, preferably the human THP1 cell line, and preserving the characteristics of immortality. Among the cell lines of the invention, the cell lines known as PSC-THP1-EP, PSC-THP1-EP-FAST, PSC-THP1-HEP and PSC-THP1-EPEP are preferred. The invention also relates to methods for obtaining the cell lines of the invention and the uses of said cell lines, particularly for the production of albumin and/or blood coagulation factors.

摘要翻译： 本发明涉及能够产生白蛋白和血液凝固因子的肝细胞表型的分化细胞的细胞系，所述细胞衍生自人白血病细胞系，优选人THP1细胞系，并保持不朽的特征。 在本发明的细胞系中，优选称为PSC-THP1-EP，PSC-THP1-EP-FAST，PSC-THP1-HEP和PSC-THP1-EPEP的细胞系。 本发明还涉及获得本发明的细胞系和所述细胞系的用途，特别是用于产生白蛋白和/或凝血因子的方法。