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    COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES
    1.
    发明申请
    COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES 审中-公开
    用于再生ATROH组织的组合物

    公开(公告)号：US20130287757A1

    公开(公告)日：2013-10-31

    申请号：US13979581

    申请日：2011-01-13

    申请人： Luisa Gennero ,  Fulvio Pedrini ,  Maurizio Pedrini ,  Gianfranco Merizzi

    发明人： Luisa Gennero ,  Fulvio Pedrini ,  Maurizio Pedrini ,  Gianfranco Merizzi

    IPC分类号： A61K31/19 ,  A61K31/198 ,  A61K33/30 ,  A61K31/60 ,  A61K38/48

    CPC分类号： A61K31/19 ,  A61K31/185 ,  A61K31/198 ,  A61K31/60 ,  A61K33/30 ,  A61K36/76 ,  A61K38/48 ,  A61K38/4873 ,  A61K45/06 ,  A61K2300/00

    摘要： An effective composition is for the therapeutic or cosmetic treatment of atrophic cutaneous and subcutaneous tissues, skin appendages, connective tissues or mucous tissues. The composition includes a combination of a salt of adamantane carboxylic acid, preferably salified with an aromatic and/or adamantane base, with a proteolytic enzyme and/or willow extract, salicylic acid, acetylsalicylic acid, salicylate, or acetylsalicylate. Further active ingredients that are suitable for inclusion in the composition are zinc oxide, vitamins, phytoextracts, sugars, amino acids, minerals, further salts, phytoextracts, ventilated green clay and any combination thereof. The composition has a particular synergy between the constituent elements, and is particularly effective in the treatment of atrophic ulcers or bedsores.

    摘要翻译： 有效的组合物用于治疗或美容治疗萎缩性皮肤和皮下组织，皮肤附属物，结缔组织或粘液组织。 组合物包括金刚烷羧酸盐，优选与芳族和/或金刚烷碱成盐与蛋白水解酶和/或柳树提取物，水杨酸，乙酰水杨酸，水杨酸酯或乙酰水杨酸酯的组合。 适于包含在组合物中的其它活性成分是氧化锌，维生素，植物提取物，糖，氨基酸，矿物质，其它盐，植物提取物，通风绿土及其任何组合。 组合物在组成元件之间具有特定的协同作用，并且在治疗萎缩性溃疡或褥疮方面特别有效。

    Use of N-Piperidine Derivative Compositions for Protecting Biological Systems
    2.
    发明申请
    Use of N-Piperidine Derivative Compositions for Protecting Biological Systems 审中-公开
    使用N-哌啶衍生物组合物保护生物系统

    公开(公告)号：US20100167260A1

    公开(公告)日：2010-07-01

    申请号：US12161232

    申请日：2007-01-18

    申请人： Gianfranco Merizzi ,  Antonio Soleti

    发明人： Gianfranco Merizzi ,  Antonio Soleti

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0226 ,  A01N1/02

    摘要： The present invention relates to compositions and the use of such compositions in the formulation of preservation solutions for protecting mammalian (including human) biological systems such as biotechnological preparations (including recombin 10d3 ant proteins), organs, tissues (including whole blood and blood derivatives such platelets and plasma) and cells (including red blood cells, pancreatic ss-cells, stem cells and germ cells) from oxidative damage occurring, for example, during the different phases of transplantation and surgery. More particularly, this invention relates to a method for protecting and/or enhancing viability of mammalian biotechnological preparations/cells/tissues/organs during isolation (or harvesting), preservation (or storage), expansion (or colture), transplantation and surgery by using compositions containing effective amount of antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine. Data supplied from the esp@cenet database—Worldwide

    摘要翻译： 本发明涉及组合物和这些组合物在制备用于保护哺乳动物（包括人）生物系统如生物技术制剂（包括重组体10d3蚂蚁蛋白），器官，组织（包括全血和血液衍生物） 血小板和血浆）和细胞（包括红细胞，胰腺β-细胞，干细胞和生殖细胞）从氧化损伤发生，例如在移植和手术的不同阶段期间发生。 更具体地说，本发明涉及一种用于在分离（或收获），保存（或储存），扩张（或串联），移植和手术期间保护和/或增强哺乳动物生物技术制剂/细胞/组织/器官的活力的方法，其通过使用 含有有效量的衍生自N-哌啶的抗氧化剂环状（双） - 羟胺的组合物。 从esp @ cenet database-Worldwide提供的数据

    PROCESS FOR PRODUCING A CELLULOSE-BASED FILM TO BE USED FOR SKIN AND TISSUE LESIONS
    5.
    发明申请
    PROCESS FOR PRODUCING A CELLULOSE-BASED FILM TO BE USED FOR SKIN AND TISSUE LESIONS 审中-公开
    用于生产用于皮肤和组织切片的基于纤维素的膜的方法

    公开(公告)号：US20100029584A1

    公开(公告)日：2010-02-04

    申请号：US12520848

    申请日：2007-08-03

    申请人： Gianfranco Merizzi

    发明人： Gianfranco Merizzi

    IPC分类号： A61K31/717 ,  C12P19/04 ,  A61P17/02

    CPC分类号： C12P19/04

    摘要： The process for producing a cellulose film, to be used for covering, regenerating, repairing and healing of skin and tissue lesions, such as sores, ulcers, burns, wounds etc. by means of cultivation, in a culture medium comprising nitrogen and carbon sources, of microorganisms comprising the Acetobacter xylinum species; the culture medium moreover comprises at least one microorganism belonging to the Leuconostoc genus.

    摘要翻译： 用于在包含氮和碳源的培养基中用于通过培养来覆盖，再生，修复和愈合皮肤和组织损伤（例如疮，溃疡，烧伤，伤口等）的纤维素膜的方法 包括木醋杆菌属物种的微生物; 该培养基还包含至少一种属于明串珠菌属的微生物。

    Use of N-piperidine derivatives for the treatment of neurodegenerative pathologies
    8.
    发明授权
    Use of N-piperidine derivatives for the treatment of neurodegenerative pathologies 失效
    使用N-哌啶衍生物治疗神经退行性病变

    公开(公告)号：US08461186B2

    公开(公告)日：2013-06-11

    申请号：US10589469

    申请日：2005-02-22

    申请人： Gianfranco Merizzi

    发明人： Gianfranco Merizzi

    IPC分类号： A61K31/44

    CPC分类号： A61K31/4545

    摘要： The present invention relates to chemical compounds, to pharmaceutical and veterinary compositions, and to the use of such compositions for the treatment or prevention of neurodegenerative pathologies and syndromes such as Parkinson's disease, Alzheimer's disease, lesions due to ischaemia and reperfusion, traumatic brain lesions, neuropathy due to HIV, Down's syndrome, diabetic polyneuropathy, muscular dystrophy, multiple sclerosis, Huntington's disease, prion disease, late dyskinesia, tauopathy and demyelinating pathologies, and other life-threatening pathologies such as cardiac/renal/pulmonary/hepatic/intestinal ischaemia-reperfusion, hypertension, diabetes, cancer, shock, toxicity due to drugs and radiation (radiotherapy and radiation protection), inflammatory conditions, atherosclerosis, aging, hyperlipidaemia, hypercholesterolaemia, epilepsy, and rheumatoid arthritis, all of which are known to be associated with an excess production of reactive free radicals. More particularly, the present invention relates to compositions containing antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine as pharmaceutical compositions for the prevention and treatment of pathologies in man and in animals.

    摘要翻译： 本发明涉及化学化合物，药物和兽医组合物，以及这些组合物用于治疗或预防神经变性病理学和综合征如帕金森病，阿尔茨海默病，由缺血和再灌注引起的损伤，创伤性脑损伤， 由于艾滋病，唐氏综合征，糖尿病性多发性神经病，肌营养不良症，多发性硬化，亨廷顿病，朊病毒疾病，晚期运动障碍，tau病和脱髓鞘病变引起的神经病，以及其他危及生命的病态如心脏/肾/肺/肝/肠缺血 - 再灌注，高血压，糖尿病，癌症，休克，由于药物和辐射引起的毒性（放射治疗和辐射防护），炎性病症，动脉粥样硬化，衰老，高脂血症，高胆固醇血症，癫痫和类风湿性关节炎，所有这些已知与 过量产生反应性自由基。 更具体地说，本发明涉及含有抗氧化剂环状（双） - 羟胺衍生自N-哌啶的组合物作为预防和治疗人和动物病理学的药物组合物。