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    ALBUMIN FOR TREATING CANCER AND A PHARMACEUTICAL COMPOSITION COMPRISING THE COMBINATION OF AN ANTI-NEOPLASTIC AGENT AND ALBUMIN
    1.
    发明申请
    ALBUMIN FOR TREATING CANCER AND A PHARMACEUTICAL COMPOSITION COMPRISING THE COMBINATION OF AN ANTI-NEOPLASTIC AGENT AND ALBUMIN 审中-公开
    用于治疗癌症的ALBUM和包含抗神经病药物与ALBUMIN的组合的药物组合物

    公开(公告)号：US20110206732A1

    公开(公告)日：2011-08-25

    申请号：US12673750

    申请日：2008-08-19

    申请人： Giampiero Pescarmona ,  Antonio Ponzetto ,  Gianfranco Merizzi ,  Luisa Gennero

    发明人： Giampiero Pescarmona ,  Antonio Ponzetto ,  Gianfranco Merizzi ,  Luisa Gennero

    IPC分类号： A61K39/04 ,  A61K38/38 ,  A61K38/12 ,  A61P35/00

    CPC分类号： A61K31/155 ,  A61K38/38

    摘要： The present invention relates to albumin as an active ingredient in a medicament for the treatment of cancer and to a pharmaceutical composition comprising at least one anti-neoplastic agent and albumin at a concentration of at least 2% w/v of the composition, in a pharmaceutically acceptable vehicle. The anti-neoplastic agent is preferably hydroxyurea, preferably at concentration between 10 μM and 1 mM, more preferably between 10 μM and 100 μM. The pharmaceutical composition of the invention is effective in the therapeutic treatment of cancer and advantageously shows reduced side effects in comparison with the administration of the anti-neoplastic agent alone.

    摘要翻译： 本发明涉及白蛋白作为用于治疗癌症的药物中的活性成分和包含至少一种浓度为组合物至少2％w / v的抗肿瘤剂和白蛋白的药物组合物，其中 药学上可接受的载体。 抗肿瘤剂优选为羟基脲，优选浓度为10μM至1mM，更优选10μM至100μM。 与单独使用抗肿瘤剂相比，本发明的药物组合物在治疗癌症方面是有效的，并且有利地显示减少的副作用。

    COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES
    5.
    发明申请
    COMPOSITION FOR THE REGENERATION OF ATROPHIC TISSUES 审中-公开
    用于再生ATROH组织的组合物

    公开(公告)号：US20130287757A1

    公开(公告)日：2013-10-31

    申请号：US13979581

    申请日：2011-01-13

    申请人： Luisa Gennero ,  Fulvio Pedrini ,  Maurizio Pedrini ,  Gianfranco Merizzi

    发明人： Luisa Gennero ,  Fulvio Pedrini ,  Maurizio Pedrini ,  Gianfranco Merizzi

    IPC分类号： A61K31/19 ,  A61K31/198 ,  A61K33/30 ,  A61K31/60 ,  A61K38/48

    CPC分类号： A61K31/19 ,  A61K31/185 ,  A61K31/198 ,  A61K31/60 ,  A61K33/30 ,  A61K36/76 ,  A61K38/48 ,  A61K38/4873 ,  A61K45/06 ,  A61K2300/00

    摘要： An effective composition is for the therapeutic or cosmetic treatment of atrophic cutaneous and subcutaneous tissues, skin appendages, connective tissues or mucous tissues. The composition includes a combination of a salt of adamantane carboxylic acid, preferably salified with an aromatic and/or adamantane base, with a proteolytic enzyme and/or willow extract, salicylic acid, acetylsalicylic acid, salicylate, or acetylsalicylate. Further active ingredients that are suitable for inclusion in the composition are zinc oxide, vitamins, phytoextracts, sugars, amino acids, minerals, further salts, phytoextracts, ventilated green clay and any combination thereof. The composition has a particular synergy between the constituent elements, and is particularly effective in the treatment of atrophic ulcers or bedsores.

    摘要翻译： 有效的组合物用于治疗或美容治疗萎缩性皮肤和皮下组织，皮肤附属物，结缔组织或粘液组织。 组合物包括金刚烷羧酸盐，优选与芳族和/或金刚烷碱成盐与蛋白水解酶和/或柳树提取物，水杨酸，乙酰水杨酸，水杨酸酯或乙酰水杨酸酯的组合。 适于包含在组合物中的其它活性成分是氧化锌，维生素，植物提取物，糖，氨基酸，矿物质，其它盐，植物提取物，通风绿土及其任何组合。 组合物在组成元件之间具有特定的协同作用，并且在治疗萎缩性溃疡或褥疮方面特别有效。

    Use of N-Piperidine Derivative Compositions for Protecting Biological Systems
    6.
    发明申请
    Use of N-Piperidine Derivative Compositions for Protecting Biological Systems 审中-公开
    使用N-哌啶衍生物组合物保护生物系统

    公开(公告)号：US20100167260A1

    公开(公告)日：2010-07-01

    申请号：US12161232

    申请日：2007-01-18

    申请人： Gianfranco Merizzi ,  Antonio Soleti

    发明人： Gianfranco Merizzi ,  Antonio Soleti

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0226 ,  A01N1/02

    摘要： The present invention relates to compositions and the use of such compositions in the formulation of preservation solutions for protecting mammalian (including human) biological systems such as biotechnological preparations (including recombin 10d3 ant proteins), organs, tissues (including whole blood and blood derivatives such platelets and plasma) and cells (including red blood cells, pancreatic ss-cells, stem cells and germ cells) from oxidative damage occurring, for example, during the different phases of transplantation and surgery. More particularly, this invention relates to a method for protecting and/or enhancing viability of mammalian biotechnological preparations/cells/tissues/organs during isolation (or harvesting), preservation (or storage), expansion (or colture), transplantation and surgery by using compositions containing effective amount of antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine. Data supplied from the esp@cenet database—Worldwide

    摘要翻译： 本发明涉及组合物和这些组合物在制备用于保护哺乳动物（包括人）生物系统如生物技术制剂（包括重组体10d3蚂蚁蛋白），器官，组织（包括全血和血液衍生物） 血小板和血浆）和细胞（包括红细胞，胰腺β-细胞，干细胞和生殖细胞）从氧化损伤发生，例如在移植和手术的不同阶段期间发生。 更具体地说，本发明涉及一种用于在分离（或收获），保存（或储存），扩张（或串联），移植和手术期间保护和/或增强哺乳动物生物技术制剂/细胞/组织/器官的活力的方法，其通过使用 含有有效量的衍生自N-哌啶的抗氧化剂环状（双） - 羟胺的组合物。 从esp @ cenet database-Worldwide提供的数据

    PROCESS FOR PRODUCING A CELLULOSE-BASED FILM TO BE USED FOR SKIN AND TISSUE LESIONS
    8.
    发明申请
    PROCESS FOR PRODUCING A CELLULOSE-BASED FILM TO BE USED FOR SKIN AND TISSUE LESIONS 审中-公开
    用于生产用于皮肤和组织切片的基于纤维素的膜的方法

    公开(公告)号：US20100029584A1

    公开(公告)日：2010-02-04

    申请号：US12520848

    申请日：2007-08-03

    申请人： Gianfranco Merizzi

    发明人： Gianfranco Merizzi

    IPC分类号： A61K31/717 ,  C12P19/04 ,  A61P17/02

    CPC分类号： C12P19/04

    摘要： The process for producing a cellulose film, to be used for covering, regenerating, repairing and healing of skin and tissue lesions, such as sores, ulcers, burns, wounds etc. by means of cultivation, in a culture medium comprising nitrogen and carbon sources, of microorganisms comprising the Acetobacter xylinum species; the culture medium moreover comprises at least one microorganism belonging to the Leuconostoc genus.

    摘要翻译： 用于在包含氮和碳源的培养基中用于通过培养来覆盖，再生，修复和愈合皮肤和组织损伤（例如疮，溃疡，烧伤，伤口等）的纤维素膜的方法 包括木醋杆菌属物种的微生物; 该培养基还包含至少一种属于明串珠菌属的微生物。