公开(公告)号：US20090054842A1

公开(公告)日：2009-02-26

申请号：US10595859

申请日：2004-11-18

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15128 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053

摘要： A microneedle device for transporting fluid through a surface of a biological barrier, the device including a fluid transport configuration, an abutment member and a displacement device. The fluid transport configuration includes a substrate having a substantially planar surface having a plurality of microneedles projecting therefrom. The abutment member has an abutment surface for abutting the biological barrier. The displacement device is configured for generating a relative lateral sliding movement between the surface of the biological barrier and the fluid transport configuration in a sliding direction of the microneedles The microneedles are arranged so that a leading microneedle defines an effective area which is effective void of another microneedle. The effective area is defined as an area marked out by translating the base area of the leading microneedle, by the height of the leading microneedle, in a direction opposite to the sliding direction.

摘要翻译： 用于输送流体通过生物屏障的表面的微针装置，该装置包括流体输送构造，抵靠构件和位移装置。 流体输送构造包括具有基本平坦表面的基底，其具有从其突出的多个微针。 抵靠构件具有用于邻接生物屏障的邻接表面。 位移装置构造成在微针的滑动方向上产生生物屏障的表面和流体输送构型之间的相对横向滑动运动。微针被布置成使得前导微针限定有效区域，其有效地与另一个无效 微针 有效面积被定义为通过将主显微针的基部区域与引导微针的高度沿与滑动方向相反的方向平移来标出的区域。

公开(公告)号：US07588552B2

公开(公告)日：2009-09-15

申请号：US10506904

申请日：2003-03-04

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61M5/425 ,  A61M2037/0023 ,  A61M2037/0038

摘要： A device (10) and method for transporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles (18) and/or microneedles (18) with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (18), thereby also enhancing penetration. Also disclosed is a device (10) and method which combine shallow penetration by hollow microneedles (18) with jet injection via the microneedles (18) to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles (18).

摘要翻译： 用于在生物屏障之间输送流体的装置（10）和方法通过使用定向插入，优选地具有尖锐边缘的不对称微针（18）和/或微针（18）来增强生物屏障的穿透。 另外，或者替代地，采用接触几何形状改变的粘合来拉伸穿过微针（18）的生物屏障，从而也增强渗透。 还公开了一种装置（10）和方法，其通过空心微针（18）通过微针（18）与喷射射流组合浅穿透，以实现大于微针（18）的机械穿透深度的总液体穿透深度。

公开(公告)号：US20060051404A1

公开(公告)日：2006-03-09

申请号：US10535252

申请日：2003-11-18

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levine

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levine

IPC分类号： A61K9/70

CPC分类号： A61B17/205 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A microstructure for transferring a substance through the surface of the skin, comprising a substrate having a first and a second side and at least one microstructure projecting from the second side of the substrate. The micrstructure has at least one hollow. The hollow is isolated from the fluid connection with the first side of the substrate. The hollow is configured such that, when the microstructure is inserted through the surface of the skin, at least part of the substance is transferred through the surface of the skin in the hollow.

摘要翻译： 用于将物质转移穿过皮肤表面的微结构，包括具有第一和第二侧面的基底和至少一个从基底的第二侧突出的微结构的基底。 微结构具有至少一个中空部。 中空部分与衬底的第一侧的流体连接隔离。 中空构造成使得当微结构体穿过皮肤表面时，物质的至少一部分通过空心中的皮肤表面转移。

公开(公告)号：US20050165358A1

公开(公告)日：2005-07-28

申请号：US10506904

申请日：2003-03-04

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yotam Levin

IPC分类号： A61M5/42 ,  A61M37/00 ,  A61M5/00

CPC分类号： A61M37/0015 ,  A61M5/425 ,  A61M2037/0023 ,  A61M2037/0038

摘要： A device (10) and method for tranporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles (18) and/or microneedles (18) with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (18), thereby also enhancing penetration. Also disclosed is a device (10) and method which combine shallow penetration by hollow microneedles (18) with jet injection via the microneedles (18) to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles (18).

摘要翻译： 用于在生物屏障之间传输流体的装置（10）和方法通过使用定向插入，优选地具有尖锐边缘的不对称微针（18）和/或微针（18）来增强生物屏障的穿透。 另外，或者替代地，采用接触几何形状改变的粘合来拉伸穿过微针（18）的生物屏障，从而也增强渗透。 还公开了一种装置（10）和方法，其通过空心微针（18）通过微针（18）与喷射射流组合浅穿透，以实现大于微针（18）的机械穿透深度的总液体穿透深度。