公开(公告)号：US20090054842A1

公开(公告)日：2009-02-26

申请号：US10595859

申请日：2004-11-18

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15128 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053

摘要： A microneedle device for transporting fluid through a surface of a biological barrier, the device including a fluid transport configuration, an abutment member and a displacement device. The fluid transport configuration includes a substrate having a substantially planar surface having a plurality of microneedles projecting therefrom. The abutment member has an abutment surface for abutting the biological barrier. The displacement device is configured for generating a relative lateral sliding movement between the surface of the biological barrier and the fluid transport configuration in a sliding direction of the microneedles The microneedles are arranged so that a leading microneedle defines an effective area which is effective void of another microneedle. The effective area is defined as an area marked out by translating the base area of the leading microneedle, by the height of the leading microneedle, in a direction opposite to the sliding direction.

摘要翻译： 用于输送流体通过生物屏障的表面的微针装置，该装置包括流体输送构造，抵靠构件和位移装置。 流体输送构造包括具有基本平坦表面的基底，其具有从其突出的多个微针。 抵靠构件具有用于邻接生物屏障的邻接表面。 位移装置构造成在微针的滑动方向上产生生物屏障的表面和流体输送构型之间的相对横向滑动运动。微针被布置成使得前导微针限定有效区域，其有效地与另一个无效 微针 有效面积被定义为通过将主显微针的基部区域与引导微针的高度沿与滑动方向相反的方向平移来标出的区域。

公开(公告)号：US08007466B2

公开(公告)日：2011-08-30

申请号：US11719541

申请日：2005-05-19

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61M5/32 ,  A61M2005/341 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (12) inserted into the biological barrier (14) is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles (12) project from a relief surface (16) which is distinct from a primary biological-barrier contact region (18, 26) of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region (18, 26) is brought into contact with the biological barrier (14) and moved parallel to the surface of the flexible biological barrier so as to generate a boundary (20) between a stretched portion (22) and a non-stretched portion (24) of the barrier. Typically concurrently with this motion, the microneedles (12) penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region (20) in a direction towards the non-stretched portion (24). Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障（14）中的微针（12）的最终位置通常从输送构型侧向突出而不是传统的向下突出的布置。 微针（12）从与输送构造的主要生物屏障接触区域（18,26）不同的浮雕表面（16）突出，并且通常向上远离生物屏障。 在插入期间，接触区域（18,26）与生物屏障（14）接触并平行于柔性生物屏障的表面移动，以便在拉伸部分（22）和 屏障的非拉伸部分（24）。 通常与该运动同时，微针（12）穿透柔性生物屏障，使得在运动结束时，微针从边界区域（20）沿着未拉伸的方向延伸到柔性生物屏障 部分（24）。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US20090247953A1

公开(公告)日：2009-10-01

申请号：US12096028

申请日：2006-12-10

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： An adapter for achieving intradermal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration for attachment to the dosed drug delivery device and a hollow needle deployed for piercing the septum. A liquid delivery interface, linked to the connector, includes a straight skin contact edge and one or more hollow microneedle adjacent thereto. The microneedle projects away from the skin contact edge. A flow path arrangement interconnects the needle and the at least one hollow microneedle.

摘要翻译： 一种用于通过使用包含具有可刺穿隔膜的储存器的剂量药物递送装置来实现液体的皮内剂量输送的适配器，所述适配器具有连接器，所述连接器包括用于附接到定量给药的药物输送装置的附接结构，以及用于刺穿 隔膜。 连接到连接器的液体传送界面包括直的皮肤接触边缘和与其相邻的一个或多个中空微针。 微针远离皮肤接触边缘。 流路布置使针和至少一个中空微针相互连接。

公开(公告)号：US20080091226A1

公开(公告)日：2008-04-17

申请号：US11549982

申请日：2006-10-17

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi

IPC分类号： A61B17/34

CPC分类号： A61B17/205 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2010/0225 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A microneedle device for delivery or sampling of fluids to or from intradermal layers of the skin of a mammalian subject includes a skin contact configuration defining an orientation of the device and a number of microneedles The microneedles are deployed relative to the skin contact configuration so that, when deployed against the skin, a first region of a peripheral surface of the microneedle is deployed roughly parallel to the initial plane of the skin. A fluid flow bore intersects the first region of the peripheral surface.

摘要翻译： 用于将流体递送或取样到哺乳动物受试者皮肤的皮内层的微针装置包括限定装置的方向和多个微针的皮肤接触构型相对于皮肤接触构造展开微针， 当相对于皮肤展开时，微针的外周表面的第一区域大致平行于皮肤的初始平面展开。 流体流动孔与周边表面的第一区域相交。

公开(公告)号：US20090157094A1

公开(公告)日：2009-06-18

申请号：US12159210

申请日：2007-01-14

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Meir Hefetz ,  Yoel Sefi ,  Gilad Lavi

IPC分类号： A61B19/00 ,  A61B17/20

CPC分类号： A61B17/54 ,  A61B2017/00734 ,  A61B2017/00747 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2017/320004

摘要： A device (100, 200) for superficial abrasive treatment of the skin includes a skin interface element (102, 202) with a number of protrusions (106, 206) projecting to a height above a substrate (104, 204) of no greater than 200 microns. A vibration generating mechanism (108, 208) is mechanically linked to the skin interface element (102, 202) so as to generate vibratory motion of the skin interface element (102, 202).

摘要翻译： 用于对皮肤进行表面磨料处理的装置（100,200）包括：皮肤界面元件（102,202），其具有突出到衬底（104,204）上方高度不大于 200微米。 振动产生机构（108,208）机械连接到皮肤界面元件（102,202），以便产生皮肤界面元件（102,202）的振动。

公开(公告)号：US20050209566A1

公开(公告)日：2005-09-22

申请号：US11134411

申请日：2005-05-23

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/00 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles inserted into the biological barrier is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles project from a relief surface which is distinct from a primary biological-barrier contact region of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region is brought into contact with the biological barrier and moved parallel to the surface of the flexible biological barrier so as to generate a boundary between a stretched portion and a non-stretched portion of the barrier. Typically concurrently with this motion, the microneedles penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region in a direction towards the non-stretched portion. Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障的微针的最终位置通常从输送构型侧向突出而不是传统的向下突出的布置。 微针从与输送构型的主要生物屏障接触区域不同的浮雕表面突出，并且通常向上远离生物屏障。 在插入期间，使接触区域与生物屏障接触并平行于柔性生物屏障的表面移动，以便在屏障的拉伸部分和非拉伸部分之间产生边界。 通常与该运动同时，微针穿透柔性生物屏障，使得在运动结束时，微针从朝向非拉伸部分的方向从边界区延伸到柔性生物屏障内。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US07998119B2

公开(公告)日：2011-08-16

申请号：US11134411

申请日：2005-05-23

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles inserted into the biological barrier is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles project from a relief surface which is distinct from a primary biological-barrier contact region of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region is brought into contact with the biological barrier and moved parallel to the surface of the flexible biological barrier so as to generate a boundary between a stretched portion and a non-stretched portion of the barrier. Typically concurrently with this motion, the microneedles penetrate into the flexible biological barrier such that, at the end of the motion, the microneedles extend into the flexible biological barrier from the boundary region in a direction towards the non-stretched portion. Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障的微针的最终位置通常从输送构型侧向突出而不是传统的向下突出的布置。 微针从与输送构型的主要生物屏障接触区域不同的浮雕表面突出，并且通常向上远离生物屏障。 在插入期间，使接触区域与生物屏障接触并平行于柔性生物屏障的表面移动，以便在屏障的拉伸部分和非拉伸部分之间产生边界。 通常与该运动同时，微针穿透柔性生物屏障，使得在运动结束时，微针从朝向非拉伸部分的方向从边界区延伸到柔性生物屏障内。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US20090069788A1

公开(公告)日：2009-03-12

申请号：US11719541

申请日：2005-05-19

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Yoel Sefi ,  Yotam Levin ,  Gilad Lavi

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M5/32 ,  A61M2005/341 ,  A61M2037/0023 ,  A61M2037/003

摘要： A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (12) inserted into the biological barrier (14) is generally sideways projecting from. the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles (12) project from a relief surface (16) which is distinct from a primary biological-barrier contact region (18, 26) of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region (18, 26) is brought into contact with the biological barrier (14) and moved parallel to the surface of the flexible biological barrier so as to generate a boundary (20) between a stretched portion (22) and a non-stretched portion (24) of the barrier. Typically concurrently with this motion, the microneedles (12) penetrate into the flexible biological barrier such that, at the end microneedles extend into the flexible biological barrier from the boundary region (20) in a direction towards the non-stretched portion (24). Fluid is then injected through the bores of the hollow microneedles towards non-stretched portion.

摘要翻译： 用于将流体输送到柔性生物屏障的系统和方法采用微针结构，其中插入生物屏障（14）中的微针（12）的最终位置通常侧向突出。 输送配置而不是常规的向下突出布置。 微针（12）从与输送构造的主要生物屏障接触区域（18,26）不同的浮雕表面（16）突出，并且通常向上远离生物屏障。 在插入期间，接触区域（18,26）与生物屏障（14）接触并平行于柔性生物屏障的表面移动，以在拉伸部分（22）和 屏障的非拉伸部分（24）。 通常与该运动同时，微针（12）穿透柔性生物屏障，使得末端微针在朝向非拉伸部分（24）的方向上从边界区域（20）延伸到柔性生物屏障内。 然后将流体通过中空微针的孔注射到非拉伸部分。

公开(公告)号：US20090012494A1

公开(公告)日：2009-01-08

申请号：US11946889

申请日：2007-11-29

申请人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

发明人： Yehoshua Yeshurun ,  Yotam Levin ,  Yotam Almagor ,  Gilad Lavi ,  Meir Hefetz ,  Yoel Sefi ,  Richard Ian Catchpole

IPC分类号： A61M5/32 ,  A61K33/00 ,  A61K38/09 ,  A61K38/22 ,  A61K31/70 ,  A61K31/7105 ,  A61K31/485 ,  A61K38/47 ,  A61K38/16 ,  A61K38/28 ,  A61K38/21 ,  A61K38/20 ,  A61K31/4748 ,  A61K31/727 ,  A61K31/166 ,  A61K31/551 ,  A61K39/395 ,  A61K31/465 ,  A61K31/702 ,  A61K31/4178 ,  A61K31/137 ,  A61K39/12 ,  A61K39/00 ,  A61K39/02 ,  A61K39/235 ,  A61K39/21 ,  A61K39/155 ,  A61K39/285 ,  A61K39/145 ,  A61K39/245 ,  A61K39/295 ,  A61P43/00

CPC分类号： A61M37/0015 ,  A61M2037/003

摘要： The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.

摘要翻译： 本发明涉及将一种或多种生物活性剂如疫苗和治疗剂皮内递送到受试者皮肤的真皮层中的方法，以使用含有该试剂的微针药物递送装置获得全身递送或免疫应答 交付 该方法采用具有一排中空微针的微针装置。 微针穿透受试者的皮肤并呈现锚定状态，其中微针锚定在皮肤中并从装置横向突出。 然后使用该装置进行枢转运动，使得将微针接合的皮肤提升到皮肤表面的初始平面之上，同时递送生物活性剂。 与常规疫苗递送途径相比，本发明的方法引起体液和/或细胞反应增加，促进剂量节省。

公开(公告)号：US20060051404A1

公开(公告)日：2006-03-09

申请号：US10535252

申请日：2003-11-18

申请人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levine

发明人： Yehoshua Yeshurun ,  Meir Hefetz ,  Gil Fruchtman ,  Yoel Sefi ,  Yotam Levine

IPC分类号： A61K9/70

CPC分类号： A61B17/205 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003

摘要： A microstructure for transferring a substance through the surface of the skin, comprising a substrate having a first and a second side and at least one microstructure projecting from the second side of the substrate. The micrstructure has at least one hollow. The hollow is isolated from the fluid connection with the first side of the substrate. The hollow is configured such that, when the microstructure is inserted through the surface of the skin, at least part of the substance is transferred through the surface of the skin in the hollow.

摘要翻译： 用于将物质转移穿过皮肤表面的微结构，包括具有第一和第二侧面的基底和至少一个从基底的第二侧突出的微结构的基底。 微结构具有至少一个中空部。 中空部分与衬底的第一侧的流体连接隔离。 中空构造成使得当微结构体穿过皮肤表面时，物质的至少一部分通过空心中的皮肤表面转移。