公开(公告)号：US20100304410A1

公开(公告)日：2010-12-02

申请号：US12677898

申请日：2008-09-26

申请人： Gregor Kijanka ,  Dermot Kenny ,  Elaine Kay

发明人： Gregor Kijanka ,  Dermot Kenny ,  Elaine Kay

IPC分类号： G01N33/53

CPC分类号： G01N33/57419

摘要： The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

摘要翻译： 本发明涉及筛选患者以识别和定量结肠直肠癌风险的方法，从而鉴定适合进一步侵入性研究的患者，例如结肠镜检查。 该方法使用显示与结肠直肠癌风险方法相关的自身抗体，并涉及从个体中检测生物标志物组合的多个生物标志物的组合中选择SEQ ID NO：1至12的生物标志物，其中生物标志物的组合为 选择使得患者中所有生物标志物的检测与患有结肠直肠癌阳性的至少50％的风险相关。 检测生物标志物的所有组合表明患者应进行结肠镜检查。 还提供了用于执行本发明的方法的套件。

公开(公告)号：US08906669B2

公开(公告)日：2014-12-09

申请号：US13123491

申请日：2009-10-09

申请人： Ivan Dimov ,  Jens Ducree ,  Luke Lee ,  Gregor Kijanka

发明人： Ivan Dimov ,  Jens Ducree ,  Luke Lee ,  Gregor Kijanka

IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N33/53 ,  B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0457 ,  B01L2400/0472 ,  Y10T436/25

摘要： A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

摘要翻译： 描述了包括具有在输入和输出之间的衬底内限定的流体路径的微流体装置的顺序流分析工具。 该装置包括设置在流体路径内但偏离流体路径的捕获​​室，捕获室沿着基本上垂直于流体路径的方向延伸到基板中，使得设置在流体流体内流动的流体内的可操作的颗粒将优先地在捕获 房间。

公开(公告)号：US20110262906A1

公开(公告)日：2011-10-27

申请号：US13123491

申请日：2009-10-09

申请人： Ivan Dimov ,  Jens Ducree ,  Luke Lee ,  Gregor Kijanka

发明人： Ivan Dimov ,  Jens Ducree ,  Luke Lee ,  Gregor Kijanka

IPC分类号： C12Q1/68 ,  C12M1/40 ,  G01N1/28 ,  G01N33/00 ,  G01N33/68 ,  G01N21/75 ,  G01N33/50 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/02

CPC分类号： B01L3/50273 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0457 ,  B01L2400/0472 ,  Y10T436/25

摘要： A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

摘要翻译： 描述了一种顺序流分析工具，其包括具有在输入和输出之间的衬底内限定的流体路径的微型虹膜装置。 该装置包括设置在流体路径内但偏离流体路径的捕获​​室，捕获室沿着基本上垂直于流体路径的方向延伸到基板中，使得设置在流体流体内流动的流体内的可操作的颗粒将优先地在捕获 房间。

公开(公告)号：US08426140B2

公开(公告)日：2013-04-23

申请号：US12677898

申请日：2008-09-26

申请人： Gregor Kijanka ,  Dermot Kenny ,  Elaine Kay

发明人： Gregor Kijanka ,  Dermot Kenny ,  Elaine Kay

IPC分类号： G01N33/53 ,  G01N33/574 ,  C12Q1/00 ,  C12Q1/68

CPC分类号： G01N33/57419

摘要： The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

摘要翻译： 本发明涉及筛选患者以识别和定量结肠直肠癌风险的方法，从而鉴定适合进一步侵入性研究的患者，例如结肠镜检查。 该方法使用显示与结肠直肠癌风险方法相关的自身抗体，并涉及从个体中检测生物标志物组合的多个生物标志物的组合中选择SEQ ID NO：1至12的生物标志物，其中生物标志物的组合为 选择使得患者中所有生物标志物的检测与患有结肠直肠癌阳性的至少50％的风险相关。 检测生物标志物的所有组合表明患者应进行结肠镜检查。 还提供了用于执行本发明的方法的套件。