公开(公告)号：US20150320319A1

公开(公告)日：2015-11-12

申请号：US14710222

申请日：2015-05-12

Applicant: ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

Inventor： ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

IPC: A61B5/00 ,  A61B1/00 ,  A61B1/31

CPC classification number: A61B5/4381 ,  A61B1/00142 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/31 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0086

Abstract: A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

Abstract translation: 直肠近红外（NIR）扫描偏振成像系统使用NIR光子预分析仪（NIRPPA）进行前列腺癌检测。 NIRPPA包括便携式直肠近红外扫描偏振成像单元和基于光纤的直肠探针，其能够通过不同波长和深度的直肠记录前列腺的2D图像，并获得前列腺的三维（3D）图像， 前列腺内异常组织的3D位置。 具有选定发射波长的二极管激光器/发光二极管（LED）用于对应于四个组织光学窗口（＃I，650nm-950nm;＃II,1,100nm-1,350）的650nm至2,400nm的NIR光谱范围 nm;＃III，1,600nm-1,870nm;和#IV，2100nm-2,300nm）。 前列腺中水（H2O），氧血红蛋白（HbO2）和脱氧血红蛋白（Hb）的指纹吸收被用作前列腺癌检测的天然生物标志物。

公开(公告)号：US5131398A

公开(公告)日：1992-07-21

申请号：US468633

申请日：1990-01-22

Applicant: Robert R. Alfano ,  Bidyut Das ,  Guichen Tang

Inventor： Robert R. Alfano ,  Bidyut Das ,  Guichen Tang

IPC: A61B5/00

CPC classification number: A61B5/0084 ,  A61B5/0071 ,  A61B5/0091 ,  A61B5/4312

Abstract: A method and apparatus for distingishing cancerous tumors and tissue from benign tumors and tissue or normal tissue using native fluorescence. The tissue to be examined is excited with a beam of monochromatic light at 300 nanometers (nm). The intensity of the native fluorescence emitted from tissue is measured at 340 and 440 nm. The ratio of the two intensities is then calculated and used as a basis for determining if the tissue is cancerous as opposed to benign or normal. The invention is based on the discovery that when tissue is excited with monochromatic light at 300 nm, the native fluorescence spectrum over the region from about 320 nm to 600 nm is the tissue that is cancerous and substantially different from the native fluorescence spectrum that would result if the tissue is either benign or normal. The technique is useful in invivo and in vitro testing of human as well as animal tissue.

Abstract translation: 使用天然荧光从良性肿瘤和组织或正常组织中分散癌性肿瘤和组织的方法和装置。 待检查的组织用300纳米（nm）的单色光束激发。 在340和440nm处测量从组织发出的天然荧光的强度。 然后计算两个强度的比例，并将其用作确定组织是否为癌性而不是良性或正常的基础。 本发明是基于以下发现：当组织被300nm的单色光激发时，在约320nm至600nm的区域上的天然荧光光谱是与天然荧光光谱相似的癌症和显着不同的组织 如果组织是良性或正常的。 该技术可用于人体和动物组织的体内和体外检测。

公开(公告)号：US5369496A

公开(公告)日：1994-11-29

申请号：US434799

申请日：1989-11-13

Applicant: Robert R. Alfano ,  Kwong M. Yoo ,  Guichen Tang

Inventor： Robert R. Alfano ,  Kwong M. Yoo ,  Guichen Tang

IPC: G01N21/47 ,  G01N21/49

CPC classification number: G01N21/4738 ,  G01N21/49 ,  G01N2021/4797

Abstract: Biological material is characterized by illuminating the material with a beam of light, measuring light scattered from the material and then determining the condition of the material using the measurements. In one embodiment the angular line shape of the backscattered light is measured and then used to determine the scattering mean free path (1) and the absorption length (la) of the light scattered in the material to find out the condition of the material. These values so obtained are compared to values for a material whose condition is normal to determine if the condition of the material being examined is abnormal or normal. In another embodiment the temporal profile of the scattered pulse is used to determine (1) and (1a). The apparatus includes a laser for illuminating a section of material to be characterized, a streak camera for detecting light scattered from the material, a video camera for imaging the output of the streak camera, a computer for processing the output of the video camera to determine (1) and (1a) and a monitor for displaying the results to determine if the condition of the material being examined is normal or abnormal.

Abstract translation: 生物材料的特征在于用光束照射材料，测量从材料散射的光，然后使用测量确定材料的状态。 在一个实施例中，测量后向散射光的角线形状，然后用于确定散射在材料中的光的散射平均自由程（1）和吸收长度（1a），以找出材料的状态。 将如此获得的这些值与条件正常的材料的值进行比较，以确定被检查材料的状况是异常还是正常。 在另一个实施例中，使用散射脉冲的时间分布来确定（1）和（1a）。 该装置包括用于照射要表征的材料的一部分的激光器，用于检测从材料散射的光的条纹相机，用于对条纹相机的输出成像的摄像机，用于处理摄像机的输出的计算机，以确定 （1）和（1a）以及用于显示结果以确定被检查材料的状况是正常还是异常的监视器。

公开(公告)号：US10362983B2

公开(公告)日：2019-07-30

申请号：US14710222

申请日：2015-05-12

Applicant: Robert R. Alfano ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

Inventor： Robert R. Alfano ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

IPC: A61B1/00 ,  A61B1/31 ,  A61B5/00

Abstract: A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.