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    TABLE-TOP UTRA SUPERCONTINUUM AND HIGHER HARMONIC GENERATION SOURCE FOR MICROSCOPY
    1.
    发明申请
    TABLE-TOP UTRA SUPERCONTINUUM AND HIGHER HARMONIC GENERATION SOURCE FOR MICROSCOPY 有权

    公开(公告)号：US20220166177A1

    公开(公告)日：2022-05-26

    申请号：US17532834

    申请日：2021-11-22

    Applicant: Robert R. Alfano

    Inventor： ROBERT R. ALFANO ,  Shah Faisal B. Mazhar ,  Mikhail Sharonov ,  Lingyan Shi

    IPC: H01S3/00 ,  G21K7/00 ,  A61B6/00 ,  G02F1/35 ,  H01S3/11

    Abstract: In this patent, we teach methods to generate coherent X-ray and UUV rays beams for X ray and UUV microscopes using intense femtosecond pulses resulting the Ultra-Supercontinuum (USC) and Higher Harmonic Generation (HHG) from χ3 and χ5 media produce from electronic and molecular Kerr effect. The response of n2 (χ3) and n4 (χ5) at the optical frequency from instantaneously response of carrier phase of envelope results in odd HHG and spectral broadening about each harmonic on the anti-Stokes side of the pump pulse at wo typically in the visible, NIR, and MIR. From the slower molecular Kerr response on femtosecond to picosecond from orientation and molecular motion on n2 and n4 which follow the envelope of optical field of the laser gives rise to extreme broadening without HHG. The resulting spectra extend on the Stokes side towards the IR, RF to DC covering most of the electromagnetic spectrum. These HHG and Super broadening covering UUV to X rays and possibly to gamma ray regime for microscopes.

    Continuous diode laser stimulated Raman gain/loss vibrational microscope
    2.
    发明授权
    Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权

    公开(公告)号：US10433731B2

    公开(公告)日：2019-10-08

    申请号：US15243207

    申请日：2016-08-22

    Applicant: Robert R. Alfano

    Inventor： Robert R. Alfano ,  Lingyan Shi ,  Yury Budansky

    IPC: A61B5/00 ,  G01N21/65

    Abstract: There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

    Spatial frequency spectrometer for and method of detection of spatial structures in materials
    3.
    发明授权
    Spatial frequency spectrometer for and method of detection of spatial structures in materials 有权

    公开(公告)号：US09804088B2

    公开(公告)日：2017-10-31

    申请号：US14580892

    申请日：2014-12-23

    Applicant: Robert R. Alfano ,  Yang Pu

    Inventor： Robert R. Alfano ,  Yang Pu

    IPC: G01B9/02 ,  G01N21/47

    CPC classification number: G01N21/4788

    Abstract: Spatial frequency spectra from periodic, aperiodic and quasi-random structures in materials are shown and used to detect differences among objects via internal coding from the spatial frequencies. The method is applied to different grades of human tissues for a new form of histology and pathology, and to detect art forgeries and coding boxes, money and papers and gems. The randomness of material structures on surface and at depths near surface can be detected from the spatial spectrum. In tissue spectral features from normal to different stages of cancer in tissue for ex vivo and in vivo applications can be recognized by different spectral fingerprints content of the spatial frequency. Similarly, the painting for the strokes of artist is different. A new type of instrument is described to analyze materials as a Spatial Frequency Spectrometer.

    Compact electromagnetic-radiation antenna
    4.
    发明授权
    Compact electromagnetic-radiation antenna 有权

    公开(公告)号：US09620858B2

    公开(公告)日：2017-04-11

    申请号：US14218864

    申请日：2014-03-18

    Applicant: Robert R. Alfano

    Inventor： Robert R. Alfano ,  M. Yu Sharonov

    IPC: H01Q7/06 ,  H01Q7/08 ,  H01Q1/36

    CPC classification number: H01Q7/08 ,  H01Q1/36 ,  H01Q7/06 ,  Y10T29/49016

    Abstract: A compact random media size antenna employing random magnetic and dielectrics nm to mm range size particles in polymer hosts is used to transfer E & M oscillations in 1 kHz to 900 Mhz range using a 1 cm to 1 meter length antenna. This is achieved by using small size particles and a random mean path length of E & M wavefront travel in and about a core tube of effective length matching Leff=L2/2ltr, equivalent to λ/2 for transmitting and receiving E & M radiation, where L is the physical size of the antenna, ltris the transport scattering random walk length between particles and λ is the frequency wavelength.

    NEAR INFRARED PHOTONIC PROSTATOSCOPY ANALYZER
    8.
    发明申请
    NEAR INFRARED PHOTONIC PROSTATOSCOPY ANALYZER 审中-公开
    近红外光子显微镜分析仪

    公开(公告)号：US20150320319A1

    公开(公告)日：2015-11-12

    申请号：US14710222

    申请日：2015-05-12

    Applicant: ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

    Inventor： ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

    IPC: A61B5/00 ,  A61B1/00 ,  A61B1/31

    CPC classification number: A61B5/4381 ,  A61B1/00142 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/31 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0086

    Abstract: A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

    Abstract translation: 直肠近红外（NIR）扫描偏振成像系统使用NIR光子预分析仪（NIRPPA）进行前列腺癌检测。 NIRPPA包括便携式直肠近红外扫描偏振成像单元和基于光纤的直肠探针，其能够通过不同波长和深度的直肠记录前列腺的2D图像，并获得前列腺的三维（3D）图像， 前列腺内异常组织的3D位置。 具有选定发射波长的二极管激光器/发光二极管（LED）用于对应于四个组织光学窗口（＃I，650nm-950nm;＃II,1,100nm-1,350）的650nm至2,400nm的NIR光谱范围 nm;＃III，1,600nm-1,870nm;和#IV，2100nm-2,300nm）。 前列腺中水（H2O），氧血红蛋白（HbO2）和脱氧血红蛋白（Hb）的指纹吸收被用作前列腺癌检测的天然生物标志物。

    Method for picosecond and femtosecond laser tissue welding
    9.
    发明授权
    Method for picosecond and femtosecond laser tissue welding 有权
    皮秒和飞秒激光组织焊接方法

    公开(公告)号：US08974444B2

    公开(公告)日：2015-03-10

    申请号：US13642746

    申请日：2011-04-20

    Applicant: Robert R. Alfano ,  Vidyasagar Sriramoju

    Inventor： Robert R. Alfano ,  Vidyasagar Sriramoju

    IPC: A61B18/20 ,  A61B17/00 ,  A61B18/00

    CPC classification number: A61B18/20 ,  A61B18/203 ,  A61B2017/00508 ,  A61B2018/00452

    Abstract: A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.

    Abstract translation: 一种用于焊接动物组织伤口的方法。 该方法包括接合伤口组织的边缘并用脉冲激光照射卷绕的组织周围的组织。 脉冲激光在组织伤口和围绕组织伤口的组织的水吸收带，弹性蛋白和/或胶原的范围内具有激光波长。 脉冲激光器具有不超过皮秒的脉冲宽度，以加热组织周围的组织，并促进存在于围绕组织伤口的组织中的天然组织蛋白质的结合以实现组织修复。 激光波长在约800nm至约2,700nm之间的范围内。

    P-ELEMENT DOPED LASER MEDIUM APPARATUS AND METHOD
    10.
    发明申请
    P-ELEMENT DOPED LASER MEDIUM APPARATUS AND METHOD 审中-公开
    P元件DOPED激光介质装置和方法

    公开(公告)号：US20130167595A1

    公开(公告)日：2013-07-04

    申请号：US13777472

    申请日：2013-02-26

    Applicant: Robert R. ALFANO ,  Alexel Bykov ,  Mikhail Sharonov

    Inventor： Robert R. ALFANO ,  Alexel Bykov ,  Mikhail Sharonov

    IPC: C03C4/00

    CPC classification number: C03C4/0071 ,  C03C1/026 ,  C03C3/00 ,  H01S3/06716 ,  H01S3/06741 ,  H01S3/1601 ,  H01S3/17

    Abstract: A method for manufacturing a glass composition including a host glass, a 3p component having a concentration of about 5 mole percent to about 10 mole percent, and at least one of a 6p component having a concentration of about 1 mole percent to about 5 mole percent and a 5p component having a concentration of about 1 mole percent to about 5 mole percent, is provided. The method includes heating the host glass to a first predetermined temperature for a first period of time; mixing a powder including the 3p component and the at least one of the 5p component and the 6p component with the heated host glass into a glass/powder mixture; heating the glass/powder mixture to a second predetermined temperature for a second period of time; and cooling, after heating, the glass/powder mixture.

    Abstract translation: 一种制造玻璃组合物的方法，所述玻璃组合物包括主体玻璃，浓度为约5摩尔％至约10摩尔％的3p组分和至少一种浓度为约1摩尔％至约5摩尔％的6p组分 并提供浓度为约1摩尔％至约5摩尔％的5p组分。 该方法包括将主机玻璃加热到第一预定温度一段时间; 将包含3p组分和5p组分和6p组分中的至少一种的粉末与加热的主体玻璃混合成玻璃/粉末混合物; 将玻璃/粉末混合物加热至第二预定温度第二段时间; 并在加热后冷却玻璃/粉末混合物。

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