公开(公告)号：US5516925A

公开(公告)日：1996-05-14

申请号：US294632

申请日：1994-08-23

申请人： Mark Pedersen ,  H. DeWayne Ashmead

发明人： Mark Pedersen ,  H. DeWayne Ashmead

IPC分类号： A23L27/20 ,  A61K31/555 ,  A61P3/00 ,  C07C229/76 ,  C07F1/00 ,  C07F1/08 ,  C07F3/00 ,  C07F3/02 ,  C07F3/04 ,  C07F3/06 ,  C07F11/00 ,  C07F13/00 ,  C07F15/02 ,  C07F15/06 ,  C07F15/00

CPC分类号： C07F15/065 ,  C07C229/76 ,  C07F1/005 ,  C07F11/005 ,  C07F13/005 ,  C07F15/025 ,  C07F3/003

摘要： A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the central metal ion while, at the same time, maintaining charge balance in the chelate molecule. There must be at least one ligand of the polydentate type which must be an .alpha.-amino acid with the further proviso that any unidentate or polydentate ligand(s) must be charge balanced organic ligands. Charge balancing may be accomplished by means of an organic acid and dicarboxylic, hydroxycarboxylic, hydroxydicarboxylic or hydroxytricarboxylic acids in particular, which maintains the chelate molecule as an optimum pH for purposes of stability and palatability.

摘要翻译： 公开了一种用于给予人和其他温血动物的可口的金属氨基酸螯合物，其中存在足够的配体以提供等于中心金属离子的配位数的离子和配位共价键，同时保持电荷平衡 在螯合分子中。 必须有至少一种多齿类型的配体，其必须是α-氨基酸，进一步的条件是任何单齿或多齿配体必须是电荷平衡的有机配体。 电荷平衡可以通过有机酸和二羧酸，羟基羧酸，羟基二羧酸或羟基三羧酸来实现，其特征在于，为了稳定性和适口性，将螯合分子保持为最佳pH。

公开(公告)号：US5292538A

公开(公告)日：1994-03-08

申请号：US918446

申请日：1992-07-22

申请人： Stephen M. Paul ,  H. DeWayne Ashmead

发明人： Stephen M. Paul ,  H. DeWayne Ashmead

IPC分类号： A23L1/302 ,  A23L1/304 ,  A23L1/305

CPC分类号： A23L33/18 ,  A23L33/15 ,  A23L33/165 ,  A23L33/175 ,  A23V2002/00

摘要： A composition which provides for sustained energy and nutrition to support an anabolic physiological state in humans comprises a blend of simple sugars and more complex carbohydrates, partially hydrolyzed protein, and, at least, magnesium in the form of an amino acid chelate. Preferably the carbohydrate source is a blend of about 5-45% crystalline fructose and 55-95% glucose polymers by weight. Other ingredients, including lipids, bioavailable minerals in the form of amino acid chelates, anabolic nutrients, vitamins, antioxidants, and lipotropic agents may be added as desired to provide an optimal sustained energy and anabolic nutrition formulation. When administered, the carbohydrate blend, protein source, and amino acid chelates facilitate sustained energy and delivery of nutrients to appropriate sites within the body for efficient utilization in anabolic physiology.

摘要翻译： 提供持续能量和营养以支持人的合成代谢生理状态的组合物包括简单糖和更复杂的碳水化合物，部分水解的蛋白质的混合物，以及至少是氨基酸螯合物形式的镁。 优选地，碳水化合物源是按重量计约5-45％结晶果糖和55-95％葡萄糖聚合物的混合物。 可以根据需要添加其它成分，包括脂质，氨基酸螯合物，合成代谢营养素，维生素，抗氧化剂和脂质剂形式的生物可利用矿物质，以提供最佳的持续能量和合成代谢营养制剂。 当施用时，碳水化合物共混物，蛋白质来源和氨基酸螯合物促进持续能量并将营养物质递送到体内适当的位点，以在合成代谢生理学中有效利用。

公开(公告)号：US5162369A

公开(公告)日：1992-11-10

申请号：US549112

申请日：1990-07-06

申请人： H. Dewayne Ashmead ,  Harvey H. Ashmead ,  Robert B. Jeppsen

发明人： H. Dewayne Ashmead ,  Harvey H. Ashmead ,  Robert B. Jeppsen

IPC分类号： A61K31/28 ,  A61K31/295 ,  A61K31/30 ,  A61K31/315

CPC分类号： A61K31/295 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315

摘要： A method for maintaining the immune system of a warm-blooded animal afflicted with a form of antigenic morbidity exacerbated by intestinal malabsorption of minerals is disclosed. Minerals selected from the group consisting of copper, zinc, manganese, iron and selenium are provided in the form of amino acid chelates having a ligand to mineral ratio of at least 1:1, a molecular weight of no more than 1500 and a stability constant of between about 10.sup.6 and 10.sup.16 and administered orally. They are absorbed from a portion of the intestinal tract other than that utilized for the absorption of cations. The method is particularly adapted to the maintaining of the immune system of a warm-blooded animal infected by a virus which compromises the absorption of trace minerals via the normal cationic absorption route. The presence of intestinal malabsorption in the host showing symptoms of antigenic morbidity is first confirmed. Based on previous data of mineral levels and ratios in assayed tissues and/or body fluids of similarly infected hosts compared with mineral levels and ratios in healthy hosts, an amino acid chelate composition is formulated and administered to the afflicted animal(s) for such time as is necessary for the immune system to be properly maintained.

摘要翻译： 公开了一种维持受到矿物质肠吸收不良加剧的抗原性发病形式的温血动物免疫系统的保护方法。 选自铜，锌，锰，铁和硒的矿物以氨基酸螯合物的形式提供，其配体的矿物比例至少为1:1，分子量不超过1500，稳定常数 约106和1016之间并口服。 除了用于吸收阳离子之外，它们被从肠道的一部分吸收。 该方法特别适用于维持受病毒感染的温血动物的免疫系统，其通过正常阳离子吸收途径损害微量矿物质的吸收。 首先证实在宿主中存在显示抗原性发病症状的宿主体内的肠吸收不良。 根据以前的类似感染宿主的测定组织和/或体液中与矿物质含量和健康宿主比例相比较的矿物质含量和比例的数据，氨基酸螯合物组合物被配制并施用于受影响的动物进行这样的时间 正如维持免疫系统所必需的那样。

公开(公告)号：US07910137B2

公开(公告)日：2011-03-22

申请号：US11483410

申请日：2006-07-07

申请人： H. DeWayne Ashmead ,  R. Charles Thompson

发明人： H. DeWayne Ashmead ,  R. Charles Thompson

IPC分类号： A61K33/24 ,  A61K33/34 ,  A61K33/32 ,  A61K33/26 ,  A61K9/48 ,  A61K9/20 ,  A61K31/28 ,  A61K31/30 ,  A61K31/295 ,  A61K31/315 ,  A01N59/16

CPC分类号： C07F9/005 ,  A23L33/165 ,  A23L33/175 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315 ,  A61K31/51 ,  A61K31/555 ,  C07C229/76 ,  C07F1/005 ,  C07F3/003 ,  C07F11/005 ,  C07F15/025

摘要： Metal carnitine chelates comprising carnitine chelated to a nutritionally relevant metal can be used for general nutrition as well as well as to treat a variety of health related problems and symptoms. For example, metal carnitine chelates can be used to maintain good cardiovascular health, increase male fertility, enhance weight loss, provide mineral and/or carnitine supplements for mineral- and/or carnitine-deficient subjects, and reduce alcohol dependency and associated symptoms. Nutritionally relevant metals that can be used include copper, zinc, magnesium, calcium, iron, chromium, and manganese, to name a few.

摘要翻译： 包含与营养相关金属螯合的肉碱的金属肉碱螯合物可用于一般营养以及治疗各种与健康有关的问题和症状。 例如，金属肉碱螯合物可用于维持良好的心血管健康状况，增加男性生殖力，增强体重减轻，为矿物和/或肉碱缺乏的受试者提供矿物质和/或肉碱补充剂，并减少酒精依赖性和相关症状。 可以使用的营养相关金属包括铜，锌，镁，钙，铁，铬和锰，仅举几例。

公开(公告)号：US20080194679A1

公开(公告)日：2008-08-14

申请号：US11706869

申请日：2007-02-14

申请人： H. DeWayne Ashmead ,  Stephen D. Ashmead

发明人： H. DeWayne Ashmead ,  Stephen D. Ashmead

IPC分类号： A61K31/28 ,  A61P39/04 ,  C07F19/00

CPC分类号： C07F19/005

摘要： The present invention is directed to methods and compositions which include high nitrogen metal amino acid chelates that can increase the metabolic activity or metal concentration in animals. In one embodiment, an amino acid composition can comprise an amino acid chelate with a first metal and first amino acid ligand, where the first amino acid ligand is devoid of a disulfide bond and has at least two nitrogen atoms, and an amino acid complex different from the amino acid chelate having a second metal and second amino acid ligand. The amino acid composition can also include nitrogen salts, proteinates, urea, nitric acid, carnitine, creatine, glucosamine, chondroitin, chitosan, nitrogen-containing botanicals, and combinations thereof.

摘要翻译： 本发明涉及包含高氮金属氨基酸螯合物的方法和组合物，其可增加动物的代谢活性或金属浓度。 在一个实施方案中，氨基酸组合物可包含具有第一金属和第一氨基酸配体的氨基酸螯合物，其中第一氨基酸配体不含二硫键且具有至少两个氮原子，并且氨基酸复合物不同 来自具有第二金属和第二氨基酸配体的氨基酸螯合物。 氨基酸组成还可包括氮盐，蛋白质，尿素，硝酸，肉碱，肌酸，葡糖胺，软骨素，壳聚糖，含氮植物药及其组合。

公开(公告)号：US06716814B2

公开(公告)日：2004-04-06

申请号：US09931397

申请日：2001-08-16

申请人： Clayton Ericson ,  H. DeWayne Ashmead

发明人： Clayton Ericson ,  H. DeWayne Ashmead

IPC分类号： A23J330

CPC分类号： C07C227/44 ,  C07C229/76

摘要： A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into existing iron amino acid chelates or iron proteinates. The iron amino acid chelates and iron proteinates may have a ligand to metal molar ratio from about 1:1 to 4:1, preferably 2:1 to 3:1.

摘要翻译： 公开了提高铁氨基酸螯合物和铁蛋白质的溶解度的方法。 这通过将有效量的有机酸增溶剂混合到现有的铁氨基酸螯合物或铁蛋白质中来实现。 铁氨基酸螯合物和铁蛋白质可以具有约1:1至4:1，优选为2:1至3:1的配体与金属的摩尔比。

公开(公告)号：US5882685A

公开(公告)日：1999-03-16

申请号：US823827

申请日：1992-01-22

申请人： H. DeWayne Ashmead

发明人： H. DeWayne Ashmead

IPC分类号： A23K1/175 ,  A23K1/18 ,  A01N59/16

CPC分类号： A23K50/30 ,  A23K20/30

摘要： A method for facilitating digestion of carbohydrates into simple sugars in warm-blooded animals by maintaining and enhancing the natural disaccharidase enzymatic activity in the mucosal cells of the small intestines. Iron is an essential mineral and other minerals selected from the group consisting of copper, zinc, manganese and cobalt are provided in the form of amino acid chelates having a ligand to mineral molar ratio of at least 1:1, a molecular weight of no more than 1500 daltons and a stability constant of between about 10.sup.6 and 10.sup.16 and administered orally. Additionally, magnesium and chromium, as amino acid chelates, may be added to improve disaccharidase activity as may potassium in inorganic salt form or as a 1:1 ligand to potassium amino acid complex. The minerals are taken into the mucosal cells lining the small intestine where they are utilized to facilitate the production and activity of disaccharidase enzymes such as maltases, sucrase and lactase. These enzymes promote the hydrolysis of disaccharides resulting from degradation of more complex carbohydrates or of sucrose and lactose into simple sugars or monosaccharides for absorption from the intestinal tract.

摘要翻译： 通过维持和增强小肠粘膜细胞中的天然二糖酶酶活性，促进在温血动物中将碳水化合物消化成简单糖的方法。 铁是一种重要的矿物质，其中选自铜，锌，锰和钴的其他矿物以氨基酸螯合物的形式提供，其配体与矿物摩尔比至少为1:1，分子量不超过 1500道尔顿，稳定常数介于约106和1016之间，口服给药。 另外，作为氨基酸螯合物可以加入镁和铬，以改善二糖苷酶的活性，如无机盐形式的钾或作为配体与钾氨基酸复合物的1:1配体。 将矿物质摄入到小肠内的粘膜细胞中，在其中它们用于促进二糖酶如麦芽糖酶，蔗糖酶和乳糖酶的产生和活性。 这些酶促进由更复杂的碳水化合物或蔗糖和乳糖降解成单糖或单糖以从肠道吸收而引起的二糖水解。

公开(公告)号：US5614553A

公开(公告)日：1997-03-25

申请号：US839828

申请日：1992-02-21

申请人： H. DeWayne Ashmead ,  Harvey H. Ashmead ,  Robert B. Jeppsen

发明人： H. DeWayne Ashmead ,  Harvey H. Ashmead ,  Robert B. Jeppsen

IPC分类号： A61K31/28 ,  A61K31/295 ,  A61K31/30 ,  A61K31/315

CPC分类号： A61K31/28 ,  A61K31/295 ,  A61K31/30 ,  A61K31/315

摘要： A method for alleviating stress and/or stress related symptoms in humans and other warm-blooded animals particularly when such symptoms are complicated by intestinal malabsorption of minerals is disclosed. Chromium and, optionally, one or more other minerals selected from the group consisting of copper, zinc, manganese, iron and selenium are provided in the form of amino acid chelates having a ligand to mineral ratio of at least 1:1, a molecular weight of no more than 1500 and a stability constant of between about 10.sup.6 and 10.sup.16 and administered orally. They are absorbed from a portion of the intestinal tract other than that utilized for the absorption of cations. The method is particularly adapted to reducing and/or controlling levels of serum cortisol in humans or other animals. The presence of symptoms of stress may first be confirmed or the compositions may be administered as a prophylactic.

摘要翻译： 公开了一种减轻人和其他温血动物的压力和/或应激相关症状的方法，特别是当这些症状由于矿物质的肠吸收不良而复杂化时。 提供了选自铜，锌，锰，铁和硒中的一种或多种其它矿物质，其配位体的配位比例至少为1:1，氨基酸螯合物的分子量 不超过1500，稳定常数介于约106和1016之间并口服。 除了用于吸收阳离子之外，它们被从肠道的一部分吸收。 该方法特别适用于减少和/或控制人或其他动物中血清皮质醇的水平。 首先可以确认应激症状的存在，或者可以将组合物作为预防剂施用。

公开(公告)号：US4863898A

公开(公告)日：1989-09-05

申请号：US826786

申请日：1986-02-06

申请人： Harvey H. Ashmead ,  H. Dewayne Ashmead ,  Darrell J. Graff

发明人： Harvey H. Ashmead ,  H. Dewayne Ashmead ,  Darrell J. Graff

IPC分类号： A61K31/28 ,  A61K31/195 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K38/00 ,  A61K38/04 ,  A61K47/18 ,  A61K47/22 ,  A61K47/42 ,  A61K47/46 ,  A61P3/00 ,  A61P43/00

CPC分类号： A61K38/04 ,  A61K31/195 ,  Y10S514/88 ,  Y10S514/891 ,  Y10S514/893

摘要： Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.

摘要翻译： 具有二价金属摩尔比为至少2:1且分子量不超过1500，优选不大于1000，并且具有约10至10的稳定常数的氨基酸螯合物被配制成用于递送至 哺乳动物内的一个或多个特定组织部位。 用于配制氨基酸螯合物的配体是天然存在的氨基酸或其二肽，三肽或四肽。 与其形成螯合物的合适配体的选择提供了当通过口服摄取或注射进入哺乳动物的血液流时具有迁移到哺乳动物内的一个或多个靶组织位点的倾向的产物。

公开(公告)号：US07455857B2

公开(公告)日：2008-11-25

申请号：US10410588

申请日：2003-04-08

申请人： Janeel Henderson ,  H. DeWayne Ashmead

发明人： Janeel Henderson ,  H. DeWayne Ashmead

IPC分类号： A61K9/20 ,  A61K9/00

CPC分类号： A61K31/525 ,  A61K31/505 ,  A61K31/555 ,  A61K31/714 ,  A61K2300/00

摘要： The present invention is drawn to an ephedra- and artificial stimulant-free energy promoting composition, comprising effective amounts of a magnesium amino acid chelate, a B vitamin, a pyruvate salt, and rhodiola. These ingredients work synergistically together to provide energy, without the use of artificial stimulants, caffeine, or ephedrine. Additional amino acid chelates can also be present, such as iron amino acid chelate, zinc amino acid chelate, copper amino acid chelate, manganese amino acid chelate, chromium amino acid chelate, and mixtures of second amino acid chelates.

摘要翻译： 本发明涉及麻黄和人造无兴奋剂促进组合物，其包含有效量的镁氨基酸螯合物，B维生素，丙酮酸盐和红景天。 这些成分协同协作，提供能量，而不使用人造兴奋剂，咖啡因或麻黄碱。 还可以存在另外的氨基酸螯合物，如铁氨基酸螯合物，锌氨基酸螯合物，铜氨基酸螯合物，锰氨基酸螯合物，铬氨基酸螯合物和第二氨基酸螯合物的混合物。