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公开(公告)号：US20220202866A1
公开(公告)日：2022-06-30
申请号：US17595045
申请日：2020-05-13
发明人： Shimon REIF , Regina GOLAN-GERSTL
摘要： The present invention is directed to compositions containing exosomes isolated from milk and methods and uses thereof for treating inflammatory bowel disease (IBD) and conditions related thereto. In particular, disclosed are exosomes derived from milk and enteral formulations supplemented therewith for use in treating IBD. The compositions are preferably formulated for rectal administration and the exosomes comprise one or more miRNA molecules and TGF-β.
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公开(公告)号：US10314873B2
公开(公告)日：2019-06-11
申请号：US14133968
申请日：2013-12-19
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , DESERT LABS AGRICULTURE COOPERATIVE ASSOCIATION LTD.
发明人： Refael Aharon , Yaron Ilan
IPC分类号： A61K36/24 , A61K36/27 , A23G9/42 , A23L33/105
摘要： A method for treating a disease comprising administering to a mammal in need thereof an effective dosage of an extract of a plant of the genus Hoodia, wherein the disease is selected from the group consisting of immune-mediated disorders, immune-associated disorders, inflammatory diseases, coronary disease, insulin resistance and liver-related diseases. In a preferred embodiment, the Hoodia is Hoodia parviflora. Also disclosed is a pharmaceutical composition for treating the above diseases comprising an effective dosage of an extract of a plant of the genus Hoodia.
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公开(公告)号：US20170333603A1
公开(公告)日：2017-11-23
申请号：US15584706
申请日：2017-05-02
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
发明人： Michael Friedman , Yoel Sasson , Ada Grin , Rami Mosheioff , Jacob Rachmilewitz
摘要： The present invention relates to a membrane comprising at least one positively charged, synthetic, hydrophobic polymer, at least one hydrophilic polymer and at least one plasticizer; wherein said membrane is flexible and is capable of supporting at least one of cell adherence, cell proliferation or cell differentiation. The invention further relates to use of a membrane of the invention in the preparation of an implantable devices including cell delivery systems, cell growing surfaces and scaffolds. The invention further provides methods for promoting tissue regeneration in a defected tissue region applying membranes of the invention.
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公开(公告)号：US20140255403A1
公开(公告)日：2014-09-11
申请号：US14198603
申请日：2014-03-06
发明人： Yaron ILAN
IPC分类号： C07K14/715
CPC分类号： C07K14/7151 , A61K31/00 , A61K38/1793 , C07K2319/30 , Y02A50/463
摘要： This application describes a method of delivering a TNF antagonist molecule, in a biologically active form, to a subject in need thereof, the method comprising, orally or mucosally administering to the subject a therapeutically effective amount of a TNF antagonist molecule.This application further describes a method of treating, preventing or reducing the severity of obesity, the method comprising, administering to the subject a therapeutically effective amount of a TNF antagonist molecule.
摘要翻译： 本申请描述了将生物活性形式的TNF拮抗剂分子递送至有需要的受试者的方法，所述方法包括向受试者口服或粘膜施用治疗有效量的TNF拮抗剂分子。 本申请进一步描述了治疗，预防或降低肥胖症的严重性的方法，所述方法包括：向受试者施用治疗有效量的TNF拮抗剂分子。
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公开(公告)号：US20220064731A1
公开(公告)日：2022-03-03
申请号：US17601069
申请日：2020-04-02
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
发明人： Yuval DOR , Ruth SHEMER , Daniel NEIMAN , Benjamin GLASER
IPC分类号： C12Q1/6881 , C12Q1/686
摘要： Primer sets comprising a 3′ region of homology to a 5′ segment of a target nucleic acid molecule and a 5′ first adapter sequence wherein the first adapter sequence comprises a 5′ first and 3′ second region and wherein said first region is between 50% and 99% of the first adapter sequence; and a second primer comprising a 3′ region identical to the first region of the first adapter sequence and a 5′ second adapter sequence are provided. Methods of performing polymerase chain reaction (PCR), producing a sequencing library and determining the cell type of origin of cell free DNA (cfDNA) are also provided.
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公开(公告)号：US20210087630A1
公开(公告)日：2021-03-25
申请号：US16970749
申请日：2019-02-18
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALMEM LTD. , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
发明人： Yuval DOR , Ruth SHEMER , Benjamin GLASER , Tomer KAPLAN , Joshua MOSS
IPC分类号： C12Q1/6881
摘要： Methods of determining the origin of cell free DNA (cfDNA) and for detecting death of a cell type or tissue in a subject by determining the origin of cfDNA in the subject are provided. Computer program products, computerized methods and computerized systems for doing same, as well as methods for constructing a methylome atlas, are also provided.
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公开(公告)号：US20210054043A1
公开(公告)日：2021-02-25
申请号：US16968967
申请日：2019-02-11
发明人： Michal LOTEM , Galit MISHAN EISENBERG , Emma HAJAJ
IPC分类号： C07K14/705 , A61K39/00 , A61P35/00
摘要： The invention relates to cancer immunotherapy, particularly to improved therapeutic modalities involving specifically modulating the expression and/or activity of SLAMF6 splice variants. More specifically, embodiments of the invention provide compositions and methods for cancer therapy, including adoptive T cell transfer therapies, cell vaccines and/or polypeptide- based medicaments. In various embodiments, compositions and methods providing selective augmentation of SLAMF6 variant 3 (SLAMF6var3) N expression or activity on T cells and/or tumor cells are provided.
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公开(公告)号：US20170281700A1
公开(公告)日：2017-10-05
申请号：US15623556
申请日：2017-06-15
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
发明人： Nissan Ronen HAZAN , Nurit BEYTH
CPC分类号： A61K35/76 , A61K9/0034 , A61K45/06 , C12N7/00 , C12N2795/10121 , C12N2795/10132 , C12N2795/10171
摘要： Isolated bacteriophages having genomes comprising the nucleic acid sequences as set forth in SEQ ID NOs: 1 and 2, or variants thereof, and compositions comprising the bacteriophages in a ratio ranging from 1:10 to 10:1, respectively. Further provided are uses of the compositions in treating or preventing an infection inflicted by a bacteria (e.g., Enterococcous faecalis and/or Enterococcous faecium). As a non-limiting example, the composition may be used in treating or preventing a root canal infection.
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公开(公告)号：US20160002312A1
公开(公告)日：2016-01-07
申请号：US14856582
申请日：2015-09-17
发明人： Yaron ILAN
IPC分类号： C07K14/715
CPC分类号： C07K14/7151 , A61K31/00 , A61K38/1793 , C07K2319/30 , Y02A50/463
摘要： This application describes a method of delivering a TNF antagonist molecule, in a biologically active form, to a subject in need thereof, the method comprising, orally or mucosally administering to the subject a therapeutically effective amount of a TNF antagonist molecule.This application further describes a method of treating, preventing or reducing liver diseases, the method comprising, administering to the subject a therapeutically effective amount of a TNF antagonist molecule.
摘要翻译： 本申请描述了将生物活性形式的TNF拮抗剂分子递送至有需要的受试者的方法，所述方法包括向受试者口服或粘膜施用治疗有效量的TNF拮抗剂分子。 本申请还描述了治疗，预防或减少肝脏疾病的方法，所述方法包括向受试者施用治疗有效量的TNF拮抗剂分子。
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公开(公告)号：US11178867B2
公开(公告)日：2021-11-23
申请号：US16079283
申请日：2017-02-26
发明人： Nathan Zaltsman , Ervin I. Weiss , Nurit Beyth
摘要： The present invention relates to anti-microbially active micro and nanoparticles, compositions comprising same, and use thereof for inhibiting bacterial growth and biofilm formation on surfaces or devices, e.g., dental surfaces or devices. The present invention further discloses methods of making such anti-microbially active micro or nanoparticles.
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