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1.发明申请SYSTEMS AND METHODS FOR AUTOMATICALLY IDENTIFYING AND SEGMENTING DIFFERENT TISSUE TYPES IN ULTRASOUND IMAGES 有权用于自动识别和分离超声图像中不同组织类型的系统和方法公开(公告)号：US20120157842A1
公开(公告)日：2012-06-21
申请号：US12971241
申请日：2010-12-17
申请人： Cynthia Elizabeth Landberg Davis , Ying Fan , Hae Won Lim , Gokul Swamy , Navneeth Subramanian , Nitya Subramaniam
发明人： Cynthia Elizabeth Landberg Davis , Ying Fan , Hae Won Lim , Gokul Swamy , Navneeth Subramanian , Nitya Subramaniam
CPC分类号： A61N7/02 , A61B8/08 , A61B8/0858 , A61B8/4245 , A61B8/4483 , A61B8/463 , A61B2017/22008 , A61B2018/00642 , A61B2018/00702 , A61B2018/00726 , A61B2018/00738 , A61B2090/378 , A61N2007/0008 , A61N2007/0039 , A61N2007/006 , A61N2007/0091 , A61N2007/0095 , G06T7/0012 , G06T7/149 , G06T2207/10132 , G06T2207/20064
摘要： A system for providing non-invasive ultrasound based treatment to a region of interest is provided. The system comprises an imaging unit for imaging one or more tissue types in the region of interest, an image processing unit that is configured to identify the one or more tissue types in the region of interest, an ultrasound transducer that is configured to focus an ultrasound beam to ablate at least a portion of the identified tissues, and a controller unit that controls a delivery of the ultrasound beam to the region of interest.
摘要翻译： 提供了一种用于向感兴趣区域提供基于非侵入性超声的治疗的系统。 该系统包括用于对感兴趣区域中的一种或多种组织类型成像的成像单元，被配置为识别感兴趣区域中的一种或多种组织类型的图像处理单元，被配置为聚焦超声波的超声波换能器 光束以消融所识别的组织的至少一部分，以及控制器单元，其控制超声波束到感兴趣区域的传送。
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公开(公告)号：US08905992B2
公开(公告)日：2014-12-09
申请号：US13290314
申请日：2011-11-07
CPC分类号： B65D25/08 , A61J1/10 , A61J1/1412 , A61J1/1462 , A61J1/1475 , A61J1/2027 , A61J1/2041 , A61J1/2093 , A61M5/1407 , B01F13/002 , B01F15/00512 , B01F15/0085 , B01F15/00896 , B01F15/0206 , B01F15/0224 , B01F2215/0032
摘要： A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.
摘要翻译： 提供便携式微泡和药物混合装置。 便携式微泡和药物混合装置包括柔性外容器，其包括用于容纳药物的内部室和柔性外部容器内的刚性内部容器，并且包括用于容纳微泡的内部室。 外容器的断裂拉伸强度小于或等于约15MPa，内部容器具有大于或等于约20MPa的拉伸强度，并且能够以高于或等于的浓度存储微泡 约5×106微泡/ ml。 内部容器构造成将内部容器的内部空间中的微泡与外部容器的内部室中的药物分离，直到微泡释放到外部容器的内部腔室中的混合点为止。
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公开(公告)号：US20130112575A1
公开(公告)日：2013-05-09
申请号：US13290314
申请日：2011-11-07
IPC分类号： B65D25/08
CPC分类号： B65D25/08 , A61J1/10 , A61J1/1412 , A61J1/1462 , A61J1/1475 , A61J1/2027 , A61J1/2041 , A61J1/2093 , A61M5/1407 , B01F13/002 , B01F15/00512 , B01F15/0085 , B01F15/00896 , B01F15/0206 , B01F15/0224 , B01F2215/0032
摘要： A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.
摘要翻译： 提供便携式微泡和药物混合装置。 便携式微泡和药物混合装置包括柔性外容器，其包括用于容纳药物的内部室和柔性外部容器内的刚性内部容器，并且包括用于容纳微泡的内部室。 外容器的断裂拉伸强度小于或等于约15MPa，内部容器具有大于或等于约20MPa的拉伸强度，并且能够以高于或等于的浓度存储微泡 约5×106微泡/ ml。 内部容器构造成将内部容器的内部空间中的微泡与外部容器的内部室中的药物分离，直到微泡释放到外部容器的内部腔室中的混合点为止。
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4.发明授权Systems and methods for automatically identifying and segmenting different tissue types in ultrasound images 有权用于自动识别和分割超声图像中不同组织类型的系统和方法公开(公告)号：US08715187B2
公开(公告)日：2014-05-06
申请号：US12971241
申请日：2010-12-17
申请人： Cynthia Elizabeth Landberg Davis , Ying Fan , Hae Won Lim , Gokul Swamy , Navneeth Subramanian , Nitya Subramaniam
发明人： Cynthia Elizabeth Landberg Davis , Ying Fan , Hae Won Lim , Gokul Swamy , Navneeth Subramanian , Nitya Subramaniam
IPC分类号： A61B8/08
CPC分类号： A61N7/02 , A61B8/08 , A61B8/0858 , A61B8/4245 , A61B8/4483 , A61B8/463 , A61B2017/22008 , A61B2018/00642 , A61B2018/00702 , A61B2018/00726 , A61B2018/00738 , A61B2090/378 , A61N2007/0008 , A61N2007/0039 , A61N2007/006 , A61N2007/0091 , A61N2007/0095 , G06T7/0012 , G06T7/149 , G06T2207/10132 , G06T2207/20064
摘要： A system for providing non-invasive ultrasound based treatment to a region of interest is provided. The system comprises an imaging unit for imaging one or more tissue types in the region of interest, an image processing unit that is configured to identify the one or more tissue types in the region of interest, an ultrasound transducer that is configured to focus an ultrasound beam to ablate at least a portion of the identified tissues, and a controller unit that controls a delivery of the ultrasound beam to the region of interest.
摘要翻译： 提供了一种用于向感兴趣区域提供基于非侵入性超声的治疗的系统。 该系统包括用于对感兴趣区域中的一种或多种组织类型成像的成像单元，被配置为识别感兴趣区域中的一种或多种组织类型的图像处理单元，被配置为聚焦超声波的超声波换能器 光束以消融所识别的组织的至少一部分，以及控制器单元，其控制超声波束到感兴趣区域的传送。
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公开(公告)号：US20130072854A1
公开(公告)日：2013-03-21
申请号：US13528399
申请日：2012-06-20
申请人： Praveena Mohan , Anup Sood , James Edward Rothman , John Donald Burczak , Hae Won Lim , Lisa Anne Lowery
发明人： Praveena Mohan , Anup Sood , James Edward Rothman , John Donald Burczak , Hae Won Lim , Lisa Anne Lowery
IPC分类号： A61K9/14 , A61K31/713 , A61K31/70 , A61K31/7088 , A61M37/00 , A61K38/02
CPC分类号： A61K31/713 , A61K9/0019 , A61K41/0028 , A61K47/06 , A61K47/554 , A61K47/64 , A61K47/643 , A61K47/6925 , A61M37/0092 , A61M2037/0007 , C12N15/111 , C12N15/1136 , C12N15/87 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.
摘要翻译： 本发明涉及一种微泡复合物，其包含具有外壳的微泡，所述微泡包含天然和包封全氟化碳气体的变性白蛋白的混合物，治疗剂，具有连接于治疗剂的一端的双功能连接体，另一端连接于配体 并且其中配体通过疏水相互作用结合到微泡的另一个壳体。 还包括用于将上述微泡复合物递送到组织靶的方法。
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公开(公告)号：US09101895B2
公开(公告)日：2015-08-11
申请号：US13087731
申请日：2011-04-15
CPC分类号： B01F11/0065 , B01F15/00253 , B01F15/00896 , B01F15/065 , B01F2215/0032
摘要： The present invention relates to functionally closed systems for mixing and delivering microbubble pharmaceuticals. Described is a device comprising a rigid outer layer and a flexible bladder wherein mixing occurs using external mixing sources. Also included is a system for dispensing the pharmaceuticals to its end use after mixing. Methods for mixing and dispensing microbubble pharmaceuticals are also described.
摘要翻译： 本发明涉及用于混合和递送微泡药物的功能闭合系统。 描述了包括刚性外层和柔性气囊的装置，其中使用外部混合源进行混合。 还包括用于在混合之后将药物分配到其最终用途的系统。 还描述了用于混合和分配微泡药物的方法。
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7.发明申请公开(公告)号：US20120263009A1
公开(公告)日：2012-10-18
申请号：US13087731
申请日：2011-04-15
CPC分类号： B01F11/0065 , B01F15/00253 , B01F15/00896 , B01F15/065 , B01F2215/0032
摘要： The present invention relates to functionally closed systems for mixing and delivering microbubble pharmaceuticals. Described is a device comprising a rigid outer layer and a flexible bladder wherein mixing occurs using external mixing sources. Also included is a system for dispensing the pharmaceuticals to its end use after mixing. Methods for mixing and dispensing microbubble pharmaceuticals are also described.
摘要翻译： 本发明涉及用于混合和递送微泡药物的功能闭合系统。 描述了包括刚性外层和柔性气囊的装置，其中使用外部混合源进行混合。 还包括用于在混合之后将药物分配到其最终用途的系统。 还描述了用于混合和分配微泡药物的方法。
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