公开(公告)号：US20070049565A1

公开(公告)日：2007-03-01

申请号：US11503379

申请日：2006-08-11

申请人： Byoung Gwag ,  Young Lee ,  Jin Shin ,  Sung Cho ,  Jae Noh ,  Jae Cho ,  Ki Kim ,  Hyang Lim ,  Jae Lee ,  Han Byun

发明人： Byoung Gwag ,  Young Lee ,  Jin Shin ,  Sung Cho ,  Jae Noh ,  Jae Cho ,  Ki Kim ,  Hyang Lim ,  Jae Lee ,  Han Byun

IPC分类号： A61K31/60 ,  A61K31/195 ,  A61K31/24 ,  A61K31/137

CPC分类号： A61K31/24 ,  A61K31/137 ,  A61K31/195 ,  A61K31/60 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a combination of cell necrosis inhibitor and lithium, process for the preparation of the combination, pharmaceutical formulation containing the combination and use of the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The combination of the present invention shows a synergic effect and thus is useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

摘要翻译： 本发明涉及细胞坏死抑制剂和锂的组合，制备该组合的方法，含有组合的药物制剂以及通过伴随或连续施用组合使用以改善神经元死亡或神经功能障碍的治疗。 本发明的组合显示出协同效应，因此可用于治疗诸如肌萎缩性侧索硬化（ALS，Lou Gehrig's disease），阿尔茨海默病，帕金森病，亨廷顿病，中风，创伤性脑损伤或脊髓损伤等神经疾病 ; 并用于治疗眼部疾病如青光眼，糖尿病性视网膜病变或黄斑变性。

公开(公告)号：US20070298129A1

公开(公告)日：2007-12-27

申请号：US11804588

申请日：2007-05-18

申请人： Byoung Gwag ,  Young Lee ,  Jin Shin ,  Sung Cho ,  Jae Noh ,  Jae Cho ,  Ki Kim ,  Hyang Lim ,  Jae Lee ,  Han Byun ,  Sun Ko ,  Sun Son ,  Sun Park

发明人： Byoung Gwag ,  Young Lee ,  Jin Shin ,  Sung Cho ,  Jae Noh ,  Jae Cho ,  Ki Kim ,  Hyang Lim ,  Jae Lee ,  Han Byun ,  Sun Ko ,  Sun Son ,  Sun Park

IPC分类号： A61K33/00 ,  A61K31/196 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  C07C229/56

CPC分类号： A61K31/137 ,  A61K31/195 ,  A61K31/24 ,  A61K31/60 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.

摘要翻译： 本发明涉及2-羟基 - 烷基氨基 - 苯甲酸衍生物和细胞坏死物抑制剂与锂的组合，制备衍生物或组合的方法，含有衍生物或组合的药物制剂及其衍生物的用途 或通过伴随或连续施用来改善神经元死亡或神经功能障碍的治疗的组合。 本发明的衍生物和组合可用于治疗神经系统疾病，例如肌萎缩性侧索硬化（ALS，Lou Gehrig's disease），脊髓性肌萎缩症，阿尔茨海默氏病，帕金森病，亨廷顿病，中风，创伤性脑损伤或脊髓 伤害 并用于治疗眼部疾病如青光眼，糖尿病性视网膜病变或黄斑变性。