利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.023 秒)

    Methods for Diagnosing and Treating Cancer
    3.
    发明申请
    Methods for Diagnosing and Treating Cancer 审中-公开
    诊断和治疗癌症的方法

    公开(公告)号：US20120252737A1

    公开(公告)日：2012-10-04

    申请号：US13499785

    申请日：2010-10-04

    申请人： Michael B. Yaffee ,  Hans Christian Reinhardt

    发明人： Michael B. Yaffee ,  Hans Christian Reinhardt

    IPC分类号： A61K38/02 ,  G01N21/64 ,  C40B30/04 ,  A61K31/713 ,  C40B40/06 ,  C40B40/10 ,  A61P35/00 ,  G01N33/574 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： The invention provides methods for decreasing one or more symptoms of cancer in a patient requiring the steps of determining the activation or inactivation of the MK2 signaling pathway and, based on these determinations, administering either a MK2 inhibitor or a combination of a MK2 inhibitor and a chemotherapeutic agent, or a chemotherapeutic agent to the patient. The invention further provides methods for identifying a cancer patient that may selectively benefit from the administration of a chemotherapeutic agent, or the administration of a MK2 inhibitor or the combination of a MK2 inhibitor and a chemotherapeutic agent, requiring the steps of determining the activation or inactivation of the MK2 signaling pathway. The invention additionally provides methods and kits for diagnosing a chemotherapy-sensitive or chemotherapy-resistant cancer in a subject that require the step of (or reagents for) determining the activation or inactivation of the MK2 signaling pathway. The invention also provides methods of treating a cancer patient diagnosed as having a chemotherapy-sensitive or a chemotherapy-resistant cancer.

    摘要翻译： 本发明提供减少患者中一种或多种癌症症状的方法，其需要确定MK2信号传导途径的激活或失活的步骤，并且基于这些测定，施用MK2抑制剂或MK2抑制剂和 化学治疗剂，或化学治疗剂。 本发明还提供了用于鉴定癌症患者的方法，所述癌症患者可选择性地受益于化疗剂的施用，或者施用MK2抑制剂或MK2抑制剂与化学治疗剂的组合，需要确定活化或灭活的步骤 的MK2信号通路。 本发明另外提供用于诊断需要用于（或）试剂）确定MK2信号通路的激活或失活的受试者的化学疗法敏感或耐化学疗法癌症的方法和试剂盒。 本发明还提供了治疗被诊断为具有化学疗法敏感性或抗化疗药物癌症的癌症患者的方法。