-
公开(公告)号：US5675058A
公开(公告)日：1997-10-07
申请号：US116845
申请日：1993-09-07
申请人： Johann J. Eibl , Hans P. Schwarz , Ludwig Pichler
发明人： Johann J. Eibl , Hans P. Schwarz , Ludwig Pichler
CPC分类号： A61K49/0008 , G01N33/4905
摘要： An in vivo assay for determining the potential thrombogenic activity of a test compound entails pre-treating an animal with both a hepatoxin and either a bacterial agent (whole bacteria or bacterial toxins, including endotoxins) or a bacterial agent-induced cytokine, which pre-treatment enhances sensitivity to thrombogenic substances. The sensitized animal can be used in identifying a thrombogenic substance even when it is a weak potentiator of thrombogenesis, and in detecting smaller amounts of a strong potentiator.
摘要翻译： 用于确定测试化合物的潜在血栓形成活性的体内测定需要用肝毒素和细菌剂（全细菌或细菌毒素，包括内毒素）或细菌剂诱导的细胞因子来预处理动物， 治疗增强对血栓形成物质的敏感性。 致敏动物即使是血栓形成的弱增强剂也可用于鉴定血栓形成物质，并且用于检测较小量的强增效剂。
-
公开(公告)号：US5549893A
公开(公告)日：1996-08-27
申请号：US429462
申请日：1995-04-27
申请人： Johann Eibl , Ludwig Pichler , Hans P. Schwarz
发明人： Johann Eibl , Ludwig Pichler , Hans P. Schwarz
IPC分类号： A61K38/43 , A61K31/00 , A61K38/00 , A61K38/46 , A61K38/48 , A61P1/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P37/00 , C07K16/40 , C12N9/64 , C12N11/08
CPC分类号： C07K16/40 , C12N11/08 , C12N9/6464 , C12Y304/21069 , A61K38/00 , Y10S514/912
摘要： There is disclosed the use of protein C or activated protein C for preparing a drug useful for the maintenance and improvement of the microcirculation in patients suffering from circulatory disturbances, in particular with the proviso that the drug does not contain any immunoglobulin G.
摘要翻译： 公开了使用蛋白质C或活化蛋白C制备可用于维持和改善患有循环障碍的患者的微循环的药物，特别是条件是药物不含有任何免疫球蛋白G.
-
3.发明授权Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation 失效使用蛋白质C或蛋白质C的活化肽制备药物制剂
公开(公告)号：US5571786A
公开(公告)日：1996-11-05
申请号：US375777
申请日：1995-01-20
申请人： Johann Eibl , Ludwig Pichler , Hans P. Schwarz , Peter Turecek
发明人： Johann Eibl , Ludwig Pichler , Hans P. Schwarz , Peter Turecek
IPC分类号： A61K9/127 , A61K38/00 , A61K38/22 , A61K38/46 , A61K38/48 , A61P25/04 , A61P29/00 , C07K16/40 , C12N9/64 , A61K38/16
CPC分类号： C07K16/40 , A61K38/33 , C12N9/6464 , C12Y304/21069 , A61K38/00 , C07K2319/00
摘要： There is disclosed the use of protein C and/or the activation peptide of protein C for preparing a pharmaceutical preparation having anti-nociceptive activity. This pharmaceutical preparation is useful in the treatment of painful conditions caused by acute or chronic inflammatory processes (such as rheumatoid arthritis, myositis, gastritis, colitis, inflammations in the urogenital tract).
摘要翻译： 公开了使用蛋白质C和/或蛋白质C的活化肽来制备具有抗伤害感受活性的药物制剂。 该药物制剂可用于治疗急性或慢性炎症过程（如类风湿性关节炎，肌炎，胃炎，结肠炎，泌尿生殖道炎症）引起的疼痛病症。
-
4.发明授权Method of dissolving venous Thrombi using drug containing activated Protein C 失效使用含活化蛋白C的药物溶解静脉血栓的方法
公开(公告)号：US5478558A
公开(公告)日：1995-12-26
申请号：US430298
申请日：1995-04-28
申请人： Johann Eibl , Yendra Linnau , Anton Philapitsch , Hans P. Schwarz
发明人： Johann Eibl , Yendra Linnau , Anton Philapitsch , Hans P. Schwarz
IPC分类号： A61K38/43 , A61K38/00 , A61K38/46 , A61K38/48 , A61K38/49 , A61K38/54 , A61K39/395 , A61K45/06 , A61P7/02 , C07K1/16 , C07K1/22 , C07K14/00 , C07K16/00 , C12N9/54 , C12N9/64 , C12N9/68 , C12N9/72 , C12N9/99
CPC分类号： C12N9/6435 , A61K38/49 , A61K45/06 , C12N9/6462 , C12N9/6464 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073
摘要： A method of dissolving venous thrombi using a thrombolytic, parenterally administrable drug containing activated protein C is described. The drug can be free of serum amyloid P, thrombin activity, infectious agents and antibodies against protein C and activated protein C.
摘要翻译： 描述了使用含有活化蛋白C的溶血栓，肠胃外给药的药物溶解静脉血栓的方法。 该药物可以不含血清淀粉样蛋白P，凝血酶活性，感染因子和抗蛋白C和活化蛋白C的抗体。
-
5.发明授权Preparation for treating and preventing thromboses and thromboembolic complications, use of such a preparation and a method of producing the same 失效用于治疗和预防血栓栓塞和血栓栓塞的制剂，这种制剂的使用及其生产方法
公开(公告)号：US5143901A
公开(公告)日：1992-09-01
申请号：US540357
申请日：1990-06-19
CPC分类号： C12N9/6464 , C07K14/745 , C07K16/36 , C07K16/40 , C12Y304/21069 , A61K38/00
摘要： A preparation for the treatment and prevention of thromboses and thromboembolic complications is disclosed, which preparation has a content of protein S at a concentration at least 50 times that present in native plasma and is free from C4b-binding protein, optionally in combination with a content of activated protein C.
摘要翻译： 公开了用于治疗和预防血栓形成和血栓栓塞并发症的制剂，该制剂具有浓度至少存在于天然血浆中的50倍的蛋白质S的含量，并且不含C4b结合蛋白，任选地与内容物组合 的活化蛋白C.
-
公开(公告)号：US5304383A
公开(公告)日：1994-04-19
申请号：US773103
申请日：1991-10-08
申请人： Johann Eibl , Anton Philapitsch , Hans P. Schwarz
发明人： Johann Eibl , Anton Philapitsch , Hans P. Schwarz
IPC分类号： A61K38/48 , A61K31/715 , A61K38/00 , A61K38/55 , A61P7/02 , C12N9/68 , A61K9/14 , A61K37/02 , A61K37/47 , A61K37/64
CPC分类号： C12N9/6435 , A61K38/55 , C12Y304/21007 , Y10S514/822 , Y10S514/922 , Y10S530/829 , Y10S530/831
摘要： There is disclosed a pharmaceutical preparation based on Lys-plasminogen and available in the lyophilized form. This preparation contains a serine-protease inhibitor and optionally an inhibitor co-factor, preferably in an amount of 0.5 to 30 nmol per mg Lys-plasminogen. This preparation is free of side-effects and may be used for the treatment and prophylaxis of plasminogen deficiency syndromes and thromboses as well as for the production of thromboresistant artificial organs.
摘要翻译： 公开了一种基于Lys-纤溶酶原的药物制剂，其冻干形式可用。 该制剂含有丝氨酸蛋白酶抑制剂和任选的抑制剂辅因子，优选为0.5至30nmol / mg Lys-纤溶酶原。 该制剂没有副作用，可用于治疗和预防纤溶酶原缺乏综合征和血栓形成以及生产抗血栓人造器官。
-
7.发明授权Preparation for treating and preventing thromboses and thromboembolic complications, use of such a preparation and a method of producing the same 失效用于治疗和预防血栓形成和血栓栓塞并发症的制备，使用这种制剂及其制备方法
公开(公告)号：US5254532A
公开(公告)日：1993-10-19
申请号：US840719
申请日：1992-02-21
CPC分类号： C12N9/6464 , C07K14/745 , C07K16/36 , C07K16/40 , C12Y304/21069 , A61K38/00
摘要： A preparation for the treatment and prevention of thromboses and thromboembolic complications is disclosed, which preparation has a content of protein S at a concentration at least 50 times that present in native plasma and is free from C4b-binding protein, optionally in combination with a content of activated protein C.
摘要翻译： 公开了用于治疗和预防血栓形成和血栓栓塞并发症的制剂，该制剂具有浓度至少存在于天然血浆中的50倍的蛋白质S的含量，并且不含C4b结合蛋白，任选地与内容物组合 的活化蛋白C.
-
8.发明授权Parenterally administrable drug having thrombolytic activity and containing protein C 失效具有溶栓活性并含有蛋白质C的可口服给药的药物
公开(公告)号：US5580962A
公开(公告)日：1996-12-03
申请号：US416533
申请日：1995-04-03
申请人： Johann Eibl , Yendra Linnau , Anton Philapitsch , Hans P. Schwarz
发明人： Johann Eibl , Yendra Linnau , Anton Philapitsch , Hans P. Schwarz
IPC分类号： A61K38/43 , A61K38/00 , A61K38/46 , A61K38/48 , A61K38/49 , A61K38/54 , A61K39/395 , A61K45/06 , A61P7/02 , C07K1/16 , C07K1/22 , C07K14/00 , C07K16/00 , C12N9/54 , C12N9/64 , C12N9/68 , C12N9/72 , C12N9/99 , C07K1/00
CPC分类号： C12N9/6435 , A61K38/49 , A61K45/06 , C12N9/6462 , C12N9/6464 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073
摘要： A thrombolytic, parenterally administrable drug containing activated protein C is provided for. The drug is free of serum amyloid P, thrombin activity, infectious agents and antibodies against protein C and activated protein C.
摘要翻译： 提供了含有活化蛋白C的溶栓剂，肠胃外给药的药物。 该药物无血清淀粉样蛋白P，凝血酶活性，感染因子和抗蛋白C和活化蛋白C的抗体。
-
公开(公告)号：US5330907A
公开(公告)日：1994-07-19
申请号：US899869
申请日：1992-06-17
申请人： Anton Philapitsch , Hans P. Schwarz
发明人： Anton Philapitsch , Hans P. Schwarz
CPC分类号： C12N9/6464 , C12Y304/21069
摘要： To produce activated protein C, protein C is treated with plasmin. Activation is effected in a quick and simple manner. Contamination of the activated protein C with thrombin is avoided.
摘要翻译： 为了生产活化蛋白C，蛋白C用纤溶酶处理。 激活以快速简单的方式进行。 避免活化蛋白C与凝血酶的污染。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.012 秒)