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    Method for producing hydroxyphenylpropionic acid ester
    5.
    发明授权
    Method for producing hydroxyphenylpropionic acid ester 失效
    羟基苯丙酸酯的制备方法

    公开(公告)号：US4754045A

    公开(公告)日：1988-06-28

    申请号：US868100

    申请日：1986-05-29

    Applicant: Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    Inventor： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    IPC: B01J23/02 ,  B01J31/12 ,  C07B61/00 ,  C07D493/10 ,  C07D319/00

    CPC classification number: C07D493/10

    Abstract: Method for producing 3,9-bis{2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionyloxy]-1,1-dimethylethyl}-2,4,8,10-tetraoxaspiro[5.5]undecane by ester exchange of a 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)-propionic acid ester with 3,9-bis(2-hydroxy-1,1-dimethylethyl)-2,4,8,10-tetraoxaspiro[5.5]-undecane at a temperature of 170.degree.-250.degree. C. using a calcium compound as a catalyst in an amount of 0.05-1.5 moles per mole of the 3,9-bis(2-hydroxy-1,1-dimethylethyl)-2,4,8,10-tetraoxaspiro[5.5]-undecane.

    Abstract translation: 制备3,9-双{2- [3-（3-叔丁基-4-羟基-5-甲基苯基）丙酰氧基] -1,1-二甲基乙基} -2,4,8,10-四氧杂螺[5.5 （3-叔丁基-4-羟基-5-甲基苯基） - 丙酸酯与3,9-双（2-羟基-1,1-二甲基乙基）-2,4， 8,10-四氧杂螺[5.5] - 十一碳烷，温度为170-250℃，使用钙化合物作为催化剂，其用量为0.05-1.5摩尔/摩尔3,9-双（2-羟基 - 1,1-二甲基乙基）-2,4,8,10-四氧杂螺[5.5] - 十一烷。

    Stabilizer for synthetic resins
    8.
    发明授权
    Stabilizer for synthetic resins 失效
    合成树脂稳定剂

    公开(公告)号：US4576734A

    公开(公告)日：1986-03-18

    申请号：US712230

    申请日：1985-03-15

    Applicant: Tamaki Ishii ,  Shinichi Yachigo ,  Manji Sasaki ,  Masahisa Shionoya ,  Haruki Okamura

    Inventor： Tamaki Ishii ,  Shinichi Yachigo ,  Manji Sasaki ,  Masahisa Shionoya ,  Haruki Okamura

    IPC: C08K5/00 ,  C08K5/1575 ,  C08K5/37 ,  C08K5/372 ,  C08K5/378 ,  C08L7/00 ,  C08L21/00 ,  C08L23/00 ,  C08L51/00 ,  C08L51/02 ,  C08L101/00 ,  C09K15/14 ,  C08K5/11

    CPC classification number: C08K5/372 ,  C08K5/1575 ,  C08K5/378

    Abstract: A stabilizer for synthetic resins containing as an effective component a mixture comprising a phenol type compound (I) represented by the formula (I), ##STR1## wherein R.sub.1 represents a C.sub.1 -C.sub.3 alkyl group, and at least one sulfur type compound (II) selected from the group consisting of compounds represented by the formula (II-1), ##STR2## wherein R.sub.2 represents a C.sub.4 -C.sub.20 alkyl group, and compounds represented by the formula (II-2), ##STR3## wherein R.sub.3 represents a C.sub.3 -C.sub.18 alkyl group, and R.sub.4 and R.sub.5 independently represent a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, the weight ratio of phenol type compound (I) to sulfur type one (II) being 1 to 0.5-15.

    Abstract translation: 含有由式（I）表示的酚型化合物（I），其中R 1表示C 1 -C 3烷基的混合物作为有效成分的合成树脂稳定剂 ，和选自由式（II-1）表示的化合物，其中R 2表示C 4 -C 20烷基的化合物，II-1所示的至少一种硫型化合物（II） 式（II-2），其中R 3表示C 3 -C 18烷基，R 4和R 5独立地表示氢原子或C 1 -C 6烷基的化合物（II-2），苯酚型化合物 （I）的硫型（II）为1〜0.5〜15。

    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof
    9.
    发明授权
    Vγ9Vδ2 T cell proliferation agent, method for producing activated Vγ9Vδ2 T cells, and uses thereof 有权
    Vγ9Vδ2T细胞增殖剂，活化的Vγ9Vδ2T细胞的制造方法及其用途

    公开(公告)号：US07749760B2

    公开(公告)日：2010-07-06

    申请号：US12316973

    申请日：2008-12-17

    Applicant: Haruki Okamura ,  Shuji Kubo ,  Wen Li

    Inventor： Haruki Okamura ,  Shuji Kubo ,  Wen Li

    IPC: C12N5/078 ,  C12N5/0783 ,  C07K14/54 ,  C07F9/40

    CPC classification number: A61K31/663 ,  A61K38/20 ,  A61K38/2013 ,  C12N5/0638 ,  C12N2501/2302 ,  C12N2501/2318 ,  C12N2501/999 ,  Y02A50/411 ,  A61K2300/00

    Abstract: A Vγ9Vδ2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since IL-18 has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vγ9Vδ2 T cell proliferation by the bisphosphonate and the IL-2. This allows providing a Vγ9Vδ2 T cell proliferation agent capable of growing Vγ9Vδ2 T cells with a proliferated efficiency significantly high compared to conventional methods so that the proliferated Vγ9Vδ2 T cells have a high antitumor activity and high cytokine productivity.

    Abstract translation: Vγ9Vδ2T细胞增殖剂包括至少二膦酸盐，白细胞介素2和白细胞介素18.由于IL-18具有通过抑制细胞死亡来改善细胞活力的性质，因此推测IL-18能够作为双膦酸盐的辅因子，以便 显着增加了双膦酸盐和IL-2对Vγ9Vδ2T细胞增殖的影响。 这允许提供与常规方法相比，能够以增殖效率显着增加Vγ9Vδ2T细胞的Vγ9Vδ2T细胞增殖剂，使得增殖的Vγ9Vδ2T细胞具有高抗肿瘤活性和高细胞因子生产力。

    Purification of hydroxyphenylpropionic acid ester
    10.
    发明授权
    Purification of hydroxyphenylpropionic acid ester 失效
    羟基苯丙酸酯的纯化

    公开(公告)号：US4739080A

    公开(公告)日：1988-04-19

    申请号：US868742

    申请日：1986-05-30

    Applicant: Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    Inventor： Manji Sasaki ,  Chinehito Ebina ,  Haruki Okamura ,  Shinichi Yachigo ,  Tamaki Ishii

    IPC: C07D493/10 ,  C08K5/1575 ,  C07D319/04

    CPC classification number: C07D493/10

    Abstract: Method for the purification of 3,9-bis{2-[3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionyloxy]-1,1-dimethylethyl} -2,4,8,10-tetraoxaspiro[5.5]undecane, to form crystals having a crystalline structure which, when subjected to Cu-K.sub..alpha. X-ray diffraction, show sharp X-ray diffraction peaks at angles of diffraction, to 2.theta.=2.8.degree., 2.theta.=8.7.degree. and 2.theta.=11.7.degree., by recrystallizing the ester at a temperature lower than 40.degree. C. using as a recrystallization solvent, A C.sub.5 -C.sub.10 alicyclic hydrocarbon, which may contain a limited amount of certain other solvents, or using a mixed solvent of a C.sub.5 -C.sub.10 aliphatic hydrocarbon and at least one other certain solvent in a certain weight ratio.

    Abstract translation: 纯化3,9-双{2- [3-（3-叔丁基-4-羟基-5-甲基苯基）丙酰氧基] -1,1-二甲基乙基} -2,4,8,10-四氧杂螺环 [5.5]十一烷，以形成具有晶体结构的晶体，当经受Cu-Kαα射线衍射时，衍射角呈现尖锐的X射线衍射峰，为2θ= 2.8°，2θ= 8.7° 和2θ= 11.7°，通过在低于40℃的温度下使酯重结晶，使用可能含有有限量的某些其它溶剂的A C5-C10脂环族烃，或使用混合溶剂 一种C 5 -C 10脂族烃和至少一种其它特定溶剂。

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