利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.012 秒)

    CORE-SHELL STRUCTURED DELIVERY SYSTEM FOR GROWTH FACTORS, A PREPARATION METHOD THEREOF, AND USE THEREOF FOR THE DIFFERENTIATION OR PROLIFERATION OF CELLS
    2.
    发明申请
    CORE-SHELL STRUCTURED DELIVERY SYSTEM FOR GROWTH FACTORS, A PREPARATION METHOD THEREOF, AND USE THEREOF FOR THE DIFFERENTIATION OR PROLIFERATION OF CELLS 审中-公开
    用于生长因子的核心结构输送系统，其制备方法及其用于细胞分化或增殖的用途

    公开(公告)号：US20110263018A1

    公开(公告)日：2011-10-27

    申请号：US12902537

    申请日：2010-10-12

    申请人： Kwideok PARK ,  Dong Keun Han ,  Dong Hoon Choi ,  Jae-Jin Kim ,  Hee Joong Kim ,  Heung Jae Chun

    发明人： Kwideok PARK ,  Dong Keun Han ,  Dong Hoon Choi ,  Jae-Jin Kim ,  Hee Joong Kim ,  Heung Jae Chun

    IPC分类号： C12N5/02 ,  C12N5/00

    CPC分类号： C12N5/0075 ,  A61K9/1647 ,  A61K9/5036 ,  C12N2533/40

    摘要： The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of each of the plurality of growth factors can be temporally controlled. Specifically, the method of preparing a microcapsule type growth factor delivery system according to the present invention includes: (1) preparing a polymeric microsphere comprising a first component, and then encapsulating the microspheres by electrodropping the polymer microsphere into another polymer comprising a second component, thereby manufacturing a core-shell structured, microcapsule type delivery system, or (2) encapsulating a polymer solution comprising a first component by electrodropping the polymer solution into another polymer comprising a second component, thereby manufacturing a core-shell structured microcapsule type delivery system. The present invention also provides a stem cell differentiation method involving bringing a microcapsule type delivery system loaded with multiple growth factors according to the present invention into contact with stem cells.

    摘要翻译： 本发明涉及一种制备能够载入对细胞分化和增殖至关重要的生物活性生长因子的递送系统的方法，其特征在于将至少两种包含生长因子的组分装载在单个载体中，由此释放 可以暂时控制多个生长因子中的每一个。 具体而言，本发明的微胶囊型生长因子递送系统的制备方法包括：（1）制备包含第一成分的聚合物微球体，然后通过将聚合物微球体电渗入另一种包含第二组分的聚合物中来包封微球体， 从而制造芯壳结构的微胶囊型输送系统，或（2）通过将聚合物溶液电渗到另一种包含第二组分的聚合物中，将包含第一组分的聚合物溶液包封，由此制造核 - 壳结构的微胶囊型递送系统。 本发明还提供一种干细胞分化方法，其包括使根据本发明的负载有多种生长因子的微胶囊型递送系统与干细胞接触。