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    Process for forming a porous PVA scaffold using a pore-forming agent
    2.
    发明授权
    Process for forming a porous PVA scaffold using a pore-forming agent 有权
    使用成孔剂形成多孔PVA支架的方法

    公开(公告)号：US08431623B2

    公开(公告)日：2013-04-30

    申请号：US13383647

    申请日：2010-05-10

    申请人： Young-Bock Shim ,  Hong-Hee Jung ,  Yon-Rak Choi ,  Ju-Woong Jang

    发明人： Young-Bock Shim ,  Hong-Hee Jung ,  Yon-Rak Choi ,  Ju-Woong Jang

    IPC分类号： C08J9/08 ,  B29C35/18

    CPC分类号： A61L27/56 ,  A61L27/16 ,  C08L29/04

    摘要： The present invention relates to a process for forming a porous poly(vinyl alcohol) (PVA) scaffold using a pore-forming agent, comprising: mixing PVA with the pore-forming agent to form micropores in the PVA scaffold and using an easily decomposable pore-forming agent after the formation of the pores to improve convenience and reduce the processing time in manufacturing the porous PVA scaffold as well as to enable a pore size and porosity to be selected. A process for forming a porous PVA scaffold using a pore-forming agent according to the present invention includes heating to melt the PVA, cooling the melted PVA and mixing the PVA with a heat-decomposable pore-forming agent, repeating the freezing/thawing of the mixed PVA to cure the PVA mixture, and stirring the cured PVA mixture with a hydrochloric acid solution at a high temperature of 65° C. or more to produce foam.

    摘要翻译： 本发明涉及使用造孔剂形成多孔聚（乙烯醇）（PVA）支架的方法，其包括：将PVA与成孔剂混合以在PVA支架中形成微孔并使用易分解孔 在形成孔之后改善方便性并减少制造多孔PVA支架的加工时间，以及能够选择孔径和孔隙率。 使用根据本发明的造孔剂形成多孔PVA支架的方法包括加热熔融PVA，冷却熔融的PVA并将PVA与可热分解的成孔剂混合，重复冻融 混合PVA以固化PVA混合物，并在65℃或更高的高温下用盐酸溶液搅拌固化的PVA混合物以产生泡沫。

    Method for purifying bone morphogenetic protein
    3.
    发明授权
    Method for purifying bone morphogenetic protein 有权
    骨形态发生蛋白纯化方法

    公开(公告)号：US08648178B2

    公开(公告)日：2014-02-11

    申请号：US13142928

    申请日：2010-05-12

    申请人： Young-Bock Shim ,  Yeong-Schick Kim ,  Yon-Rak Choi ,  Ju-Woong Jang

    发明人： Young-Bock Shim ,  Yeong-Schick Kim ,  Yon-Rak Choi ,  Ju-Woong Jang

    IPC分类号： C07K14/51 ,  C07K1/14 ,  C07K1/16 ,  C07K1/34 ,  C07K1/36

    CPC分类号： C07K14/51

    摘要： The present invention relates to a method for purifying a protein belonging to the TGF-β, superfamily, preferably BMP, and more preferably BMP-2. According to the invention, the number of purification steps is reduced and the purification process is simplified, compared to the conventional BMP-2 purification method. Thus, the time required for purification can be shortened and the cost can be reduced. In addition, the invention solves the problem that as the time for purification increases and the number of purification steps increases, BMP-2 is degraded by protease or lost during purification steps, resulting in a decrease in the final yield of BMP-2. Thus, the invention increases the final yield of BMP-2. In addition, according to the invention, although the number of purification steps is reduced, BMP-2 having high purity is obtained in high yield by optimizing and using filtrations and chromatographies, and columns, types and concentrations of buffers, and a cut-off size of membrane used in diafiltration, which are different from those of the conventional BMP-2 purification method.

    摘要翻译： 本发明涉及一种纯化属于TGF-β，超家族，优选BMP，更优选BMP-2的蛋白质的方法。 根据本发明，与常规的BMP-2纯化方法相比，纯化步骤的数量减少，并且简化了纯化过程。 因此，可以缩短净化所需的时间，降低成本。 此外，本发明解决了随着纯化时间增加和纯化步骤数量增加的问题，BMP-2在纯化步骤中被蛋白酶降解或损失，导致BMP-2的最终产率降低。 因此，本发明提高了BMP-2的最终产率。 此外，根据本发明，虽然减少了纯化步骤的数量，但是通过优化和使用过滤和色谱以及缓冲液的列，类型和浓度以及截止值，可以高产率获得高纯度的BMP-2 在渗滤中使用的膜的尺寸与常规BMP-2纯化方法不同。

    Cancellous bone graft substitute and method of manufacturing the same
    4.
    发明授权
    Cancellous bone graft substitute and method of manufacturing the same 有权
    松质骨移植替代物及其制造方法

    公开(公告)号：US08409623B2

    公开(公告)日：2013-04-02

    申请号：US12359125

    申请日：2009-01-23

    申请人： Young Bock Shim ,  Ju Woong Jang ,  Hyang Kim ,  Kwang Il Lee ,  Keun Soo Lee ,  Il Hwan Kim

    发明人： Young Bock Shim ,  Ju Woong Jang ,  Hyang Kim ,  Kwang Il Lee ,  Keun Soo Lee ,  Il Hwan Kim

    IPC分类号： A61K35/32

    CPC分类号： A61K35/32

    摘要： A cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute are provided, and more particularly, a cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute by which defatting, demineralizing, cleaning, and sterilizing processes are performed within a short time using a supersonic cabitation without damaging a surface and an inside of a bone tissue so as to further rapidly, effectively supply an allogeneic or xenogeneic bone graft substitute. Internal and external concentrations of Ca++ of the allogeneic or xenogeneic bone graft substitute are effectively removed so as to maintain physical properties of the allogenetic or xenogeneic bone graft substitute.

    摘要翻译： 提供了一种松质骨移植物替代物和一种制造松质骨移植物替代物的方法，更具体地说，涉及一种松质骨移植物替代物以及通过其进行脱脂，脱矿质，清洁和消毒处理的松质骨移植替代物的制造方法 在短时间内使用超音速驾驶，而不会破坏骨组织的表面和内部，以进一步快速，有效地提供同种异体或异种骨移植物替代物。 同种异体或异种骨移植物替代物的Ca ++的内部和外部浓度被有效去除，以保持同种异体或异种骨移植物替代物的物理性质。

    Pedicle screw
    5.
    发明授权
    Pedicle screw 有权
    椎弓根螺钉

    公开(公告)号：US08080036B2

    公开(公告)日：2011-12-20

    申请号：US12359103

    申请日：2009-01-23

    申请人： Young Bock Shim ,  Ju Woong Jang ,  Dae Kwan Kim ,  Sok Kyun Hong

    发明人： Young Bock Shim ,  Ju Woong Jang ,  Dae Kwan Kim ,  Sok Kyun Hong

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/7032

    摘要： A pedicle screw is provided to be inserted into and fixed to a pedicle of a spinal disease patient, and more particularly, a pedicle screw in which a screw thread of a clamp screw is formed to have dents and protrusions with trapezoid cross-sections so as to form a predetermined gap with a screw thread of a fixing unit having dents and protrusions with rectangular cross-sections when the clamp screw is combined with the fixing unit, and the screw thread of the clamp screw has different pitches to disperse an external impact so as to further firmly combine the clamp screw with the fixing unit.

    摘要翻译： 提供椎弓根螺钉插入并固定到脊椎病患者的椎弓根上，更具体地说，是一种椎弓根螺钉，其中夹紧螺钉的螺纹形成有具有梯形横截面的凹陷和突起，以便 与夹紧螺钉与定影单元组合时，具有具有矩形横截面的凹陷和突起的定影单元的螺纹形成预定的间隙，并且夹紧螺钉的螺纹具有不同的间距以分散外部冲击，因此 以进一步牢固地将夹紧螺丝与定影单元组合。

    PEDICLE SCREW
    6.
    发明申请
    PEDICLE SCREW 有权
    PEDICLE螺丝

    公开(公告)号：US20100094353A1

    公开(公告)日：2010-04-15

    申请号：US12359103

    申请日：2009-01-23

    申请人： Young Bock Shim ,  Ju Woong Jang ,  Dae Kwan Kim ,  Sok Kyun Hong

    发明人： Young Bock Shim ,  Ju Woong Jang ,  Dae Kwan Kim ,  Sok Kyun Hong

    IPC分类号： A61B17/04

    CPC分类号： A61B17/7037 ,  A61B17/7032

    摘要： A pedicle screw is provided to be inserted into and fixed to a pedicle of a spinal disease patient, and more particularly, a pedicle screw in which a screw thread of a clamp screw is formed to have dents and protrusions with trapezoid cross-sections so as to form a predetermined gap with a screw thread of a fixing unit having dents and protrusions with rectangular cross-sections when the clamp screw is combined with the fixing unit, and the screw thread of the clamp screw has different pitches to disperse an external impact so as to further firmly combine the clamp screw with the fixing unit.

    摘要翻译： 提供椎弓根螺钉插入并固定到脊椎病患者的椎弓根上，更具体地说，是一种椎弓根螺钉，其中夹紧螺钉的螺纹形成有具有梯形横截面的凹陷和突起，以便 与夹紧螺钉与定影单元组合时，具有具有矩形横截面的凹陷和突起的定影单元的螺纹形成预定的间隙，并且夹紧螺钉的螺纹具有不同的间距以分散外部冲击，因此 以进一步牢固地将夹紧螺丝与定影单元组合。

    Methods for preparation of tetragonal zirconia polycrystal composites
    7.
    发明授权
    Methods for preparation of tetragonal zirconia polycrystal composites 失效
    四方晶氧化锆多晶复合材料的制备方法

    公开(公告)号：US5556816A

    公开(公告)日：1996-09-17

    申请号：US398618

    申请日：1995-03-01

    申请人： Dae-Joon Kim ,  Ju-Woong Jang ,  Hyung-Jin Jung

    发明人： Dae-Joon Kim ,  Ju-Woong Jang ,  Hyung-Jin Jung

    IPC分类号： C04B35/48 ,  C04B35/488

    CPC分类号： C04B35/488

    摘要： A method for the preparation of tetragonal zirconia polycrystal composite with high toughness and low-temperature degradation resistance. The method comprising adding transformable TZP of ZrO.sub.2 --Y.sub.2 O.sub.3 --Nb.sub.2 O.sub.5 /Ta.sub.2 O.sub.5 system to non-transformable TZP of ZrO.sub.2 --Y.sub.2 O.sub.3 --Nb.sub.2 O.sub.5 /Ta.sub.2 O.sub.5 system in an amount of not more than 60% by weight based on the total weight of the resulting mixture; and sintering the mixture at above 1,500.degree. C. Even though being exposed to a temperature ranging from 100.degree. to 400.degree. C. for a long time in air, the TZP composite prepared by the present method is rarely transformed into monoclinic zirconia and yet exhibits high toughness.

    摘要翻译： 一种制备具有高韧性和低温降解性的四方晶氧化锆多晶复合材料的制备方法。 该方法包括以ZrO 2 -Y 2 O 3 -Nb 2 O 5 / Ta 2 O 5体系的不可转化TZP为基准，将ZrO2-Y2O3-Nb2O5 / Ta2O5系统的可变形TZP以不超过60重量％的量加入到所得混合物中; 并在1500℃以上烧结该混合物。尽管在空气中长时间暴露于100-400℃的温度下，通过本发明方法制备的TZP复合材料很少转变为单斜氧化锆， 高韧性

    METHOD FOR PURIFYING BONE MORPHOGENETIC PROTEIN
    10.
    发明申请
    METHOD FOR PURIFYING BONE MORPHOGENETIC PROTEIN 有权
    净化骨形态蛋白的方法

    公开(公告)号：US20130060012A1

    公开(公告)日：2013-03-07

    申请号：US13142928

    申请日：2010-05-12

    申请人： Young - Bock Shim ,  Yeong - Schick Kim ,  Yon - Rak Choi ,  Ju - Woong Jang

    发明人： Young - Bock Shim ,  Yeong - Schick Kim ,  Yon - Rak Choi ,  Ju - Woong Jang

    IPC分类号： C07K1/36 ,  C07K14/71

    CPC分类号： C07K14/51

    摘要： The present invention relates to a method for purifying a protein belonging to the TGF-β, superfamily, preferably BMP, and more preferably BMP-2. According to the invention, the number of purification steps is reduced and the purification process is simplified, compared to the conventional BMP-2 purification method. Thus, the time required for purification can be shortened and the cost can be reduced. In addition, the invention solves the problem that as the time for purification increases and the number of purification steps increases, BMP-2 is degraded by protease or lost during purification steps, resulting in a decrease in the final yield of BMP-2. Thus, the invention increases the final yield of BMP-2. In addition, according to the invention, although the number of purification steps is reduced, BMP-2 having high purity is obtained in high yield by optimizing and using filtrations and chromatographies, and columns, types and concentrations of buffers, and a cut-off size of membrane used in diafiltration, which are different from those of the conventional BMP-2 purification method.

    摘要翻译： 本发明涉及一种纯化属于TGF-βb，超家族，优选BMP，更优选BMP-2的蛋白质的方法。 根据本发明，与常规的BMP-2纯化方法相比，纯化步骤的数量减少，并且简化了纯化过程。 因此，可以缩短净化所需的时间，降低成本。 此外，本发明解决了随着纯化时间增加和纯化步骤数量增加的问题，BMP-2在纯化步骤中被蛋白酶降解或损失，导致BMP-2的最终产率降低。 因此，本发明提高了BMP-2的最终产率。 此外，根据本发明，虽然减少了纯化步骤的数量，但是通过优化和使用过滤和色谱以及缓冲液的列，类型和浓度以及截止值，可以高产率获得高纯度的BMP-2 在渗滤中使用的膜的尺寸与常规BMP-2纯化方法不同。