公开(公告)号：US20100267143A1

公开(公告)日：2010-10-21

申请号：US12607793

申请日：2009-10-28

申请人： Kwi Deok Park ,  Hee Joong Kim ,  Dong Keun Han ,  Yu Jin Hong ,  Heung Jae Chun ,  Ju Woong Jang

发明人： Kwi Deok Park ,  Hee Joong Kim ,  Dong Keun Han ,  Yu Jin Hong ,  Heung Jae Chun ,  Ju Woong Jang

IPC分类号： C12N5/071

CPC分类号： C12N5/0068 ,  C12N2533/18 ,  C12N2533/40

摘要： The present invention relates to a method for the surface modification of a polymeric scaffold for stem cell transplantation using a decellularized extracellular matrix. The method for the surface modification of the polymeric scaffold according to the present invention can embody a biomimetic surface environment that is effective for initial cell attachment, cell growth and differentiation of stem cells by modifying the surface of the polymeric scaffold using the decellularized extracellular matrix directly derived from specific tissue cells.

摘要翻译： 本发明涉及使用脱细胞的细胞外基质进行干细胞移植的聚合物支架的表面改性的方法。 根据本发明的用于表面改性的聚合物支架的方法可以体现通过使用脱细胞的细胞外基质直接修饰聚合物支架的表面来实现对初始细胞附着，细胞生长和干细胞分化有效的仿生表面环境 衍生自特定组织细胞。

公开(公告)号：US10106402B2

公开(公告)日：2018-10-23

申请号：US12985549

申请日：2011-01-06

申请人： Dong Keun Han ,  Kwi Deok Park ,  Jong Hee Kang ,  Bong Soo Lee ,  Ji Yeon Choi ,  Chang Hun Kum

发明人： Dong Keun Han ,  Kwi Deok Park ,  Jong Hee Kang ,  Bong Soo Lee ,  Ji Yeon Choi ,  Chang Hun Kum

IPC分类号： B32B5/16 ,  A61L31/10 ,  B82Y5/00 ,  A61L17/06 ,  A61L27/04 ,  A61L27/34 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14

摘要： Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.

公开(公告)号：US08734911B2

公开(公告)日：2014-05-27

申请号：US12912913

申请日：2010-10-27

申请人： Dong Keun Han ,  Kwi Deok Park ,  Jae-Jin Kim ,  Chul Ho Park ,  Seong Bae Cho

发明人： Dong Keun Han ,  Kwi Deok Park ,  Jae-Jin Kim ,  Chul Ho Park ,  Seong Bae Cho

IPC分类号： B05D3/06 ,  B05D3/08 ,  H05H1/00

CPC分类号： B05D7/14 ,  A61L27/00 ,  A61L27/28 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/12 ,  A61L2400/18 ,  B05D1/18 ,  B05D3/142 ,  Y10T428/273 ,  Y10T428/31678 ,  C08L67/04

摘要： Disclosed is nanocoupling of a polymer onto a surface of a metal substrate for improving coating adhesion of the polymer on the metal substrate, and in vivo stability and durability of the polymer. In accordance with the present invention, the polymers can be grafted via a chemical bonding on the surface of the metal substrate by the nanocoupling, by which adhesion, biocompatibility and durability of a polymer-coated layer which is to be formed later on the metal substrate were remarkably improved; therefore, the nanocoupling according to the present invention can be applied to surface modification of a metal implant, such as stents, mechanical valves, and an articular, a spinal, a dental and an orthopedic implants.

摘要翻译： 公开了聚合物在金属基材的表面上的纳米偶联，用于改善聚合物在金属基材上的涂层粘附性，以及聚合物的体内稳定性和耐久性。 根据本发明，聚合物可以通过纳米偶联在金属基材的表面上通过化学键接合，由此将在金属基材上稍后形成的聚合物涂覆层的粘附性，生物相容性和耐久性 显着改善; 因此，根据本发明的纳米偶联可以应用于诸如支架，机械瓣膜以及关节，脊柱，牙科和矫形植入物的金属植入物的表面改性。

公开(公告)号：US20120070650A1

公开(公告)日：2012-03-22

申请号：US12985549

申请日：2011-01-06

申请人： Dong Keun Han ,  Kwi Deok Park ,  Jong Hee Kang ,  Bong Soo Lee ,  Ji Yeon Choi ,  Chang Hun Kum

发明人： Dong Keun Han ,  Kwi Deok Park ,  Jong Hee Kang ,  Bong Soo Lee ,  Ji Yeon Choi ,  Chang Hun Kum

IPC分类号： B32B5/16 ,  A61L31/10 ,  B82Y5/00

CPC分类号： B82Y5/00 ,  A61L17/06 ,  A61L27/04 ,  A61L27/34 ,  A61L27/58 ,  A61L31/02 ,  A61L31/10 ,  A61L31/148 ,  Y10T428/254

摘要： Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.

摘要翻译： 公开了包括表面改性金属颗粒和生物可降解聚合物的生物医学植入物; 其用于抑制炎症; 以及制备生物医学材料的方法，包括：（a）用聚合物改性碱性金属颗粒的表面以获得表面改性的金属颗粒; 和（b）将表面改性的金属颗粒与可生物降解的聚合物混合，然后制造可生物降解的生物医学植入物，或将所得混合物涂覆在常规的生物医学植入物上。