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    PORTABLE IMAGING SUBJECT CARTRIDGE
    1.
    发明申请
    PORTABLE IMAGING SUBJECT CARTRIDGE 审中-公开
    便携式成像主体盒

    公开(公告)号：US20120041302A1

    公开(公告)日：2012-02-16

    申请号：US12857469

    申请日：2010-08-16

    申请人： David G. NILSON ,  Bradley W. RICE ,  Heng XU ,  Tamara L. TROY

    发明人： David G. NILSON ,  Bradley W. RICE ,  Heng XU ,  Tamara L. TROY

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/70 ,  A61B6/04 ,  A61B6/0414 ,  A61B6/0421 ,  A61B6/0442 ,  A61B6/0492 ,  A61B6/508 ,  A61B6/5247 ,  A61B2503/40 ,  A61B2562/17 ,  A61D1/00 ,  A61D7/04 ,  A61G10/026 ,  A61M16/01 ,  A61M2250/00

    摘要： An imaging subject handling system includes multiple portable imaging subject cartridges that optionally compress and anesthetize living imaging subjects therein during imaging, multiple receiving bases installed within separate imaging systems that interface with the cartridges, and multiple gas delivery systems that deliver an anesthetic gas flow to an installed cartridge. The cartridges include a gas delivery interface that accepts the anesthetic gas flow and provides it to the imaging subject, and one or more walls, a bottom and a top defining a closed interior that retains the anesthetic gas therewithin while the cartridge is in transport between separate imaging systems. The walls, bottom and/or top can be optically transparent and radiolucent to facilitate imaging. The cartridge can include a locking mechanism, a nose cone for the imaging subject, and co-registration features located on outside surfaces to facilitate the merging of images within software from multiple separate imaging systems.

    摘要翻译： 成像对象处理系统包括多个便携式成像对象盒，其可选地在成像期间压缩和麻醉其中的生物成像对象，多个接收基座安装在与盒相接触的分开的成像系统内，以及多个气体输送系统，其将麻醉气体流传递到 安装墨盒 药筒包括气体输送界面，其接受麻醉气体流并将其提供给成像对象，以及一个或多个壁，底部和顶部，其限定封闭的内部，其中所述麻醉气体在其间保持在分离 成像系统。 墙壁，底部和/或顶部可以是光学透明的并且是可透射的以便于成像。 盒可以包括锁定机构，用于成像对象的鼻锥，以及位于外表面上的共同配准特征，以便于在多个单独的成像系统内将软件中的图像合并。

    Systems and methods for tomographic image reconstruction
    2.
    发明授权
    Systems and methods for tomographic image reconstruction 有权
    断层图像重建的系统和方法

    公开(公告)号：US08000775B2

    公开(公告)日：2011-08-16

    申请号：US12088845

    申请日：2006-04-27

    申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

    摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

    摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

    Fluorescent light tomography
    3.
    发明授权
    Fluorescent light tomography 有权
    荧光光断层扫描

    公开(公告)号：US07599731B2

    公开(公告)日：2009-10-06

    申请号：US11733358

    申请日：2007-04-10

    申请人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

    发明人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

    IPC分类号： A61B6/03 ,  A61B6/12

    CPC分类号： A61B5/0073 ,  G01N21/49 ,  G01N2021/1787 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439

    摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

    摘要翻译： 本文描述了用于获得样品（例如哺乳动物）内荧光探针分布的三维（3D）表示的系统和方法。 使用a）来自一个或多个图像的荧光发射数据，b）哺乳动物的表面表示，以及c）计算机实现的光子传播模型，所述系统和方法在哺乳动物中产生荧光探针分布的3D表示。 分布可以指示 - 哺乳动物中一种或多种荧光探针的位置，大小和/或亮度或浓度。

    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION
    4.
    发明申请
    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION 有权
    用于图像图像重构的系统和方法

    公开(公告)号：US20090247847A1

    公开(公告)日：2009-10-01

    申请号：US12088845

    申请日：2006-04-27

    申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    IPC分类号： A61B6/03 ,  A61B5/1455

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

    摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

    摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

    SPECTRAL UNMIXING FOR IN-VIVO IMAGING
    6.
    发明申请
    SPECTRAL UNMIXING FOR IN-VIVO IMAGING 审中-公开
    用于血管成像的光谱特征

    公开(公告)号：US20080051665A1

    公开(公告)日：2008-02-28

    申请号：US11844920

    申请日：2007-08-24

    申请人： Heng Xu ,  Bradley Rice

    发明人： Heng Xu ,  Bradley Rice

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B2503/40 ,  G01N21/6428 ,  G01N21/6456

    摘要： Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.

    摘要翻译： 本文描述了用于体内光数据的光谱解混合的系统和方法。 光谱解混合根据来自多个内部光源的光谱分离图像数据，以分离一个或多个感兴趣的光谱。 光谱解混合获得具有不同和已知的激发和发射限制的组合的图像。 然后，光谱解混合使用迭代解法来分离多个荧光光源的光谱，并为至少一个内部光源提供光谱和/或空间分布图。

    FLUORESCENT LIGHT TOMOGRAPHY
    7.
    发明申请
    FLUORESCENT LIGHT TOMOGRAPHY 有权
    荧光灯

    公开(公告)号：US20080031494A1

    公开(公告)日：2008-02-07

    申请号：US11829927

    申请日：2007-07-29

    申请人： Bradley RICE ,  Chaincy KUO ,  Daniel STEARNS ,  Heng XU

    发明人： Bradley RICE ,  Chaincy KUO ,  Daniel STEARNS ,  Heng XU

    IPC分类号： G06K9/00

    CPC分类号： A61B5/0073 ,  G01N21/49 ,  G01N2021/1787 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439

    摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

    摘要翻译： 本文描述了用于获得样品（例如哺乳动物）内荧光探针分布的三维（3D）表示的系统和方法。 使用a）来自一个或多个图像的荧光发射数据，b）哺乳动物的表面表示，以及c）计算机实现的光子传播模型，所述系统和方法在哺乳动物中产生荧光探针分布的3D表示。 分布可以指示 - 哺乳动物中一种或多种荧光探针的位置，大小和/或亮度或浓度。

    Surface construction using combined photographic and structured light information
    9.
    发明授权
    Surface construction using combined photographic and structured light information 有权
    使用组合的照相和结构光信息进行表面施工

    公开(公告)号：US08044996B2

    公开(公告)日：2011-10-25

    申请号：US11429420

    申请日：2006-05-04

    申请人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

    发明人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

    IPC分类号： H04N13/02 ,  G06K9/00 ,  G01B11/24

    CPC分类号： A61B5/1077 ,  A61B5/0059 ,  A61B5/1079 ,  G01B11/25 ,  G01N21/532 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/6439 ,  G06T7/521

    摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.

    摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。

    ELECTRONIC CIGARETTE AND PROCESS OF MANUFACTURING SAME
    10.
    发明申请
    ELECTRONIC CIGARETTE AND PROCESS OF MANUFACTURING SAME 有权

    公开(公告)号：US20220095682A1

    公开(公告)日：2022-03-31

    申请号：US17456378

    申请日：2021-11-24

    申请人： Heng Xu

    发明人： Heng Xu

    IPC分类号： A24F40/42 ,  A24F40/70 ,  A24F40/46 ,  A24F40/485

    摘要： An electronic cigarette and a process of manufacturing same are provided. The electronic cigarette includes a shell including a first inlet; a connection member on top of the shell and including a tube; a tank in the shell for storing air and e-liquid; an atomizer through the tank with a vacuum defined between the atomizer and the tank, the atomizer including a heating element, a power supply member, a second inlet through the atomizer, a first connection tube interconnecting the atomizer and the connection member, and a channel through the atomizer to communicate with the tank; and a cylinder in the shell and including a rod moveably projecting out of the shell, a biasing member put on the rod and biased between a limit plate and the cylinder, a cylindrical member, a plunger, and a tube member interconnecting the cylindrical member and the tank.