公开(公告)号：US08669106B2

公开(公告)日：2014-03-11

申请号：US12351630

申请日：2009-01-09

申请人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin McIntosh ,  Hiranmoy Das ,  Yukang Zhao

发明人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin McIntosh ,  Hiranmoy Das ,  Yukang Zhao

IPC分类号： C12N5/00

CPC分类号： C12N5/0075 ,  A61K2035/124 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0641 ,  C12N5/0647 ,  C12N5/069 ,  C12N5/0691 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2500/46 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/145 ,  C12N2501/23 ,  C12N2506/11 ,  C12N2510/02 ,  C12N2533/30

摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.

摘要翻译： 本发明尤其提供用于扩展CD133 +细胞的方法和系统。 本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。 本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。 本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。

公开(公告)号：US20190091310A1

公开(公告)日：2019-03-28

申请号：US16143034

申请日：2018-09-26

申请人： Stephen E. Wright ,  Hiranmoy Das

发明人： Stephen E. Wright ,  Hiranmoy Das

IPC分类号： A61K39/00 ,  A61K38/20

摘要： The present invention includes compositions and methods comprising: a cancer antigen-specific chimeric antigen receptor cells, e.g., alpha-beta cell receptor T cells, gamma delta cell receptor T cells, induced pluripotent stem cells, hematopoietic stem cells, or natural killer (NK) cells or gamma delta cell receptor T cells, genetically engineered to express non-released IL-12, anchored IL-12, and/or cleavage-resistant IL-12 only, transfected with one or more costimulatory genes; and one or more immune modulators, regulated for safety, in an amount sufficient to eliminate the effect of at least one of myeloid derived suppressor cells (MDSC) or Tregs on the cells or CAR-T cells and eliminate cancer cells.

公开(公告)号：US20090285892A1

公开(公告)日：2009-11-19

申请号：US12351630

申请日：2009-01-09

申请人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin Mclntosh ,  Hiranmoy Das ,  Yukang Zhao

发明人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin Mclntosh ,  Hiranmoy Das ,  Yukang Zhao

IPC分类号： A61K9/00 ,  A61K35/12 ,  C12N5/08 ,  C12N5/06 ,  C12M1/00

CPC分类号： C12N5/0075 ,  A61K2035/124 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0641 ,  C12N5/0647 ,  C12N5/069 ,  C12N5/0691 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2500/46 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/145 ,  C12N2501/23 ,  C12N2506/11 ,  C12N2510/02 ,  C12N2533/30

摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.

摘要翻译： 本发明尤其提供用于扩展CD133 +细胞的方法和系统。 本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。 本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。 本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。