公开(公告)号：US20100272605A1

公开(公告)日：2010-10-28

申请号：US12428689

申请日：2009-04-23

申请人： Kevin Mclntosh ,  Walt L. Carpenter

发明人： Kevin Mclntosh ,  Walt L. Carpenter

IPC分类号： A61M1/32 ,  A61M1/10

CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M2206/16

摘要： Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: at least one pump that is provided in a core of the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the at least one pump and between which blood from the at least one pump can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and through which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

摘要翻译： 公开了一种用于对体外循环中的血液进行氧化和控制的装置。 该装置具有从入口径向向外定位的入口和出口，以便限定穿过该装置的流路。 所述装置包括：至少一个泵，其设置在所述装置的芯部中，并且可以通过所述入口供应来自患者的血液; 包括多个传热元件的热​​交换器，所述多个传热元件布置在所述至少一个泵的周围，并且来自所述至少一个泵的血液可以径向向外移动; 以及包括多个气体交换元件的氧合器，所述多个气体交换元件布置在所述热交换器周围，并且来自所述热交换器的血液可以在通过所述出口离开所述设备之前径向向外移动。

公开(公告)号：US20090285892A1

公开(公告)日：2009-11-19

申请号：US12351630

申请日：2009-01-09

申请人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin Mclntosh ,  Hiranmoy Das ,  Yukang Zhao

发明人： Ramasamy Sakthivel ,  Donald J. Brown ,  Hai-Quan Mao ,  Luc Douay ,  Vincent J. Pompili ,  Kevin Mclntosh ,  Hiranmoy Das ,  Yukang Zhao

IPC分类号： A61K9/00 ,  A61K35/12 ,  C12N5/08 ,  C12N5/06 ,  C12M1/00

CPC分类号： C12N5/0075 ,  A61K2035/124 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0641 ,  C12N5/0647 ,  C12N5/069 ,  C12N5/0691 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2500/46 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/145 ,  C12N2501/23 ,  C12N2506/11 ,  C12N2510/02 ,  C12N2533/30

摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.

摘要翻译： 本发明尤其提供用于扩展CD133 +细胞的方法和系统。 本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。 本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。 本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。

公开(公告)号：US20070293385A1

公开(公告)日：2007-12-20

申请号：US11810071

申请日：2007-06-04

申请人： Victor Dolecek ,  Gary Berg ,  Kenneth Merte ,  David Malcolm ,  Kevin Mclntosh ,  Vitaly Sitko

发明人： Victor Dolecek ,  Gary Berg ,  Kenneth Merte ,  David Malcolm ,  Kevin Mclntosh ,  Vitaly Sitko

IPC分类号： B04B5/00

CPC分类号： A61M1/3693 ,  A61M1/1081 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2205/331 ,  B04B5/0442 ,  B04B7/02 ,  B04B13/00 ,  A61M2202/0092

摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

摘要翻译： 一种离心法和相应的系统，用于处理血液以收集血小板富集血浆。 通过以填充旋转速度旋转分离室并从填充注射器泵送血液，从填充注射器中填充分离室。 软旋转用于通过以柔软的旋转速率旋转分离室来最初将红细胞与血小板分离。 将血液的一部分从分离室抽出回填充注射器以除去分离的红细胞。 分离出的血液的第二部分从分离室抽出直到检测到红细胞/血小板界面。 通过以更高的速率旋转分离室来进行硬旋转，并且通过绘制预定的清除体积来连接管被清除红细胞。 然后将富血小板血浆收集在收集注射器中。