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1.发明申请METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION 失效用于扩增AC133 +细胞和指导差异的方法和系统公开(公告)号：US20090285892A1
公开(公告)日：2009-11-19
申请号：US12351630
申请日：2009-01-09
申请人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin Mclntosh , Hiranmoy Das , Yukang Zhao
发明人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin Mclntosh , Hiranmoy Das , Yukang Zhao
CPC分类号： C12N5/0075 , A61K2035/124 , B82Y5/00 , B82Y30/00 , C12N5/0641 , C12N5/0647 , C12N5/069 , C12N5/0691 , C12N2500/25 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2506/11 , C12N2510/02 , C12N2533/30
摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.
摘要翻译： 本发明尤其提供用于扩展CD133 +细胞的方法和系统。 本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。 本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。 本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。
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2.发明授权Erythrocytes differentiated in vitro from nanofiber expanded CD133+ cells 失效体外从纳米纤维扩增的CD133 +细胞分化的红细胞公开(公告)号：US08669106B2
公开(公告)日：2014-03-11
申请号：US12351630
申请日：2009-01-09
申请人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin McIntosh , Hiranmoy Das , Yukang Zhao
发明人： Ramasamy Sakthivel , Donald J. Brown , Hai-Quan Mao , Luc Douay , Vincent J. Pompili , Kevin McIntosh , Hiranmoy Das , Yukang Zhao
IPC分类号： C12N5/00
CPC分类号： C12N5/0075 , A61K2035/124 , B82Y5/00 , B82Y30/00 , C12N5/0641 , C12N5/0647 , C12N5/069 , C12N5/0691 , C12N2500/25 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2506/11 , C12N2510/02 , C12N2533/30
摘要： The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.
摘要翻译： 本发明尤其提供用于扩展CD133 +细胞的方法和系统。 本发明进一步提供用于增加有需要的受试者（例如缺血性心肌）中缺血组织的血流量的方法和系统。 本发明还提供了用于指导扩增的CD133 +细胞分化的方法和系统。 本发明还提供了在有需要的受试者中用分化细胞治疗受试者的方法和系统。
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公开(公告)号：US20190091310A1
公开(公告)日：2019-03-28
申请号：US16143034
申请日：2018-09-26
申请人： Stephen E. Wright , Hiranmoy Das
发明人： Stephen E. Wright , Hiranmoy Das
摘要： The present invention includes compositions and methods comprising: a cancer antigen-specific chimeric antigen receptor cells, e.g., alpha-beta cell receptor T cells, gamma delta cell receptor T cells, induced pluripotent stem cells, hematopoietic stem cells, or natural killer (NK) cells or gamma delta cell receptor T cells, genetically engineered to express non-released IL-12, anchored IL-12, and/or cleavage-resistant IL-12 only, transfected with one or more costimulatory genes; and one or more immune modulators, regulated for safety, in an amount sufficient to eliminate the effect of at least one of myeloid derived suppressor cells (MDSC) or Tregs on the cells or CAR-T cells and eliminate cancer cells.
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