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公开(公告)号：US4381595A
公开(公告)日：1983-05-03
申请号：US184171
申请日：1980-09-04
申请人： Masahiko Denda , Shinichi Sato , Wataru Wakamiya , Hiroshi Harada , Natsuro Tsubouchi , Hirokazu Miyoshi
发明人： Masahiko Denda , Shinichi Sato , Wataru Wakamiya , Hiroshi Harada , Natsuro Tsubouchi , Hirokazu Miyoshi
IPC分类号： H01L21/314 , H01L21/768 , H01L21/90
CPC分类号： H01L21/3144 , H01L21/768
摘要： A multilayer interconnection is prepared by forming a stable insulating film on a nitride film which is formed on a first interconnection metal layer, and then, a second interconnection metal layer is formed on the insulating film. The insulating film can be made of aluminum oxide, an oxynitride or the other metal oxide. A silicon rich layer can be used for this purpose.
摘要翻译： 通过在形成在第一互连金属层上的氮化物膜上形成稳定的绝缘膜，然后在绝缘膜上形成第二互连金属层来制备多层互连。 绝缘膜可以由氧化铝，氧氮化物或其它金属氧化物制成。 为此，可以使用富硅层。
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2.发明授权Fluorescent silica nano-particle, fluorescent nano-material, and biochip and assay using the same 有权荧光二氧化硅纳米颗粒，荧光纳米材料和生物芯片及其分析使用公开(公告)号：US09260656B2
公开(公告)日：2016-02-16
申请号：US11898787
申请日：2007-09-14
IPC分类号： C12Q1/00 , C09K11/06 , B82Y30/00 , C12Q1/68 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/58 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/08 , C09B67/00
CPC分类号： C09K11/06 , B01J2219/005 , B01J2219/00576 , B82Y30/00 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/0005 , C09B68/443 , C12Q1/6834 , C12Q1/6837 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/587 , C12Q2563/155 , C12Q2563/107
摘要： Colloidal silica particles containing a fluorescent dye compound, composed of a silica particle containing a silica component and a fluorescent dye compound chemically bound or adsorbed thereto,wherein the colloidal silica particles containing a fluorescent dye compound have an average diameter of 30 nm or less, and wherein said silica particles are used simultaneously as fluorescent-labelling nanobeads; a fluorescent nano-material comprising said colloidal silica particles; and a biochip and an assay method using the same.
摘要翻译： 含有荧光染料化合物的胶体二氧化硅颗粒由含有二氧化硅组分的二氧化硅颗粒和化学键合或吸附的荧光染料化合物组成，其中含有荧光染料化合物的胶体二氧化硅颗粒的平均直径为30nm以下， 其中所述二氧化硅颗粒同时用作荧光标记纳米珠; 包含所述胶体二氧化硅颗粒的荧光纳米材料; 以及使用其的生物芯片和测定方法。
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3.发明授权System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination 有权通过流式细胞术定量检测和分离细胞的生物分子的系统和方法，以及用于其中的荧光二氧化硅颗粒，以及组合的多种二氧化硅颗粒的试剂盒公开(公告)号：US08796040B2
公开(公告)日：2014-08-05
申请号：US12230121
申请日：2008-08-22
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/552 , G01N15/1459 , G01N21/6428 , G01N33/54313 , G01N33/582 , G01N2021/6421 , G01N2021/6441 , Y10T436/101666 , Y10T436/13 , Y10T436/143333
摘要： A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
摘要翻译： 一种定量测定生物分子的系统，其具有：允许荧光二氧化硅颗粒能够发射由流式细胞仪可检测的荧光，以捕获荧光标记的靶标生物分子用于定量测定; 使用流式细胞仪检测从荧光二氧化硅颗粒本身发出的荧光; 并测量标记的目标生物分子的荧光强度，从而定量测定目标生物分子。
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4.发明申请Fluorescent silica nano-particle, fluorescent nano-material, and biochip and assay using the same 有权荧光二氧化硅纳米颗粒，荧光纳米材料和生物芯片及其分析使用公开(公告)号：US20080293584A1
公开(公告)日：2008-11-27
申请号：US11898787
申请日：2007-09-14
CPC分类号： C09K11/06 , B01J2219/005 , B01J2219/00576 , B82Y30/00 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/0005 , C09B68/443 , C12Q1/6834 , C12Q1/6837 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/587 , C12Q2563/155 , C12Q2563/107
摘要： Colloidal silica particles containing a fluorescent dye compound, composed of a silica particle containing a silica component and a fluorescent dye compound chemically bound or adsorbed thereto,wherein the colloidal silica particles containing a fluorescent dye compound have an average diameter of 30 nm or less, and wherein said silica particles are used simultaneously as fluorescent-labelling nanobeads; a fluorescent nano-material comprising said colloidal silica particles; and a biochip and an assay method using the same.
摘要翻译： 含有荧光染料化合物的胶体二氧化硅颗粒由含有二氧化硅组分的二氧化硅颗粒和化学键合或吸附的荧光染料化合物组成，其中含有荧光染料化合物的胶态二氧化硅颗粒的平均直径为30nm以下， 其中所述二氧化硅颗粒同时用作荧光标记纳米珠; 包含所述胶体二氧化硅颗粒的荧光纳米材料; 以及使用其的生物芯片和测定方法。
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5.发明申请System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination 有权通过流式细胞术定量检测和分离细胞的生物分子的系统和方法，以及用于其中的荧光二氧化硅颗粒，以及组合的多种二氧化硅颗粒的试剂盒公开(公告)号：US20090068639A1
公开(公告)日：2009-03-12
申请号：US12230121
申请日：2008-08-22
CPC分类号： G01N33/552 , G01N15/1459 , G01N21/6428 , G01N33/54313 , G01N33/582 , G01N2021/6421 , G01N2021/6441 , Y10T436/101666 , Y10T436/13 , Y10T436/143333
摘要： A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
摘要翻译： 一种定量测定生物分子的系统，其具有：允许荧光二氧化硅颗粒能够发射由流式细胞仪可检测的荧光，以捕获荧光标记的靶标生物分子用于定量测定; 使用流式细胞仪检测从荧光二氧化硅颗粒本身发出的荧光; 并测量标记的目标生物分子的荧光强度，从而定量测定目标生物分子。
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