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1.发明申请System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination 有权通过流式细胞术定量检测和分离细胞的生物分子的系统和方法，以及用于其中的荧光二氧化硅颗粒，以及组合的多种二氧化硅颗粒的试剂盒公开(公告)号：US20090068639A1
公开(公告)日：2009-03-12
申请号：US12230121
申请日：2008-08-22
CPC分类号： G01N33/552 , G01N15/1459 , G01N21/6428 , G01N33/54313 , G01N33/582 , G01N2021/6421 , G01N2021/6441 , Y10T436/101666 , Y10T436/13 , Y10T436/143333
摘要： A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
摘要翻译： 一种定量测定生物分子的系统，其具有：允许荧光二氧化硅颗粒能够发射由流式细胞仪可检测的荧光，以捕获荧光标记的靶标生物分子用于定量测定; 使用流式细胞仪检测从荧光二氧化硅颗粒本身发出的荧光; 并测量标记的目标生物分子的荧光强度，从而定量测定目标生物分子。
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2.发明授权Fluorescent silica nano-particle, fluorescent nano-material, and biochip and assay using the same 有权荧光二氧化硅纳米颗粒，荧光纳米材料和生物芯片及其分析使用公开(公告)号：US09260656B2
公开(公告)日：2016-02-16
申请号：US11898787
申请日：2007-09-14
IPC分类号： C12Q1/00 , C09K11/06 , B82Y30/00 , C12Q1/68 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/58 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/08 , C09B67/00
CPC分类号： C09K11/06 , B01J2219/005 , B01J2219/00576 , B82Y30/00 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/0005 , C09B68/443 , C12Q1/6834 , C12Q1/6837 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/587 , C12Q2563/155 , C12Q2563/107
摘要： Colloidal silica particles containing a fluorescent dye compound, composed of a silica particle containing a silica component and a fluorescent dye compound chemically bound or adsorbed thereto,wherein the colloidal silica particles containing a fluorescent dye compound have an average diameter of 30 nm or less, and wherein said silica particles are used simultaneously as fluorescent-labelling nanobeads; a fluorescent nano-material comprising said colloidal silica particles; and a biochip and an assay method using the same.
摘要翻译： 含有荧光染料化合物的胶体二氧化硅颗粒由含有二氧化硅组分的二氧化硅颗粒和化学键合或吸附的荧光染料化合物组成，其中含有荧光染料化合物的胶体二氧化硅颗粒的平均直径为30nm以下， 其中所述二氧化硅颗粒同时用作荧光标记纳米珠; 包含所述胶体二氧化硅颗粒的荧光纳米材料; 以及使用其的生物芯片和测定方法。
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3.发明授权System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination 有权通过流式细胞术定量检测和分离细胞的生物分子的系统和方法，以及用于其中的荧光二氧化硅颗粒，以及组合的多种二氧化硅颗粒的试剂盒公开(公告)号：US08796040B2
公开(公告)日：2014-08-05
申请号：US12230121
申请日：2008-08-22
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/552 , G01N15/1459 , G01N21/6428 , G01N33/54313 , G01N33/582 , G01N2021/6421 , G01N2021/6441 , Y10T436/101666 , Y10T436/13 , Y10T436/143333
摘要： A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
摘要翻译： 一种定量测定生物分子的系统，其具有：允许荧光二氧化硅颗粒能够发射由流式细胞仪可检测的荧光，以捕获荧光标记的靶标生物分子用于定量测定; 使用流式细胞仪检测从荧光二氧化硅颗粒本身发出的荧光; 并测量标记的目标生物分子的荧光强度，从而定量测定目标生物分子。
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4.发明申请Fluorescent silica nano-particle, fluorescent nano-material, and biochip and assay using the same 有权荧光二氧化硅纳米颗粒，荧光纳米材料和生物芯片及其分析使用公开(公告)号：US20080293584A1
公开(公告)日：2008-11-27
申请号：US11898787
申请日：2007-09-14
CPC分类号： C09K11/06 , B01J2219/005 , B01J2219/00576 , B82Y30/00 , C09B11/24 , C09B23/04 , C09B23/06 , C09B67/0005 , C09B68/443 , C12Q1/6834 , C12Q1/6837 , C40B70/00 , G01N33/533 , G01N33/552 , G01N33/587 , C12Q2563/155 , C12Q2563/107
摘要： Colloidal silica particles containing a fluorescent dye compound, composed of a silica particle containing a silica component and a fluorescent dye compound chemically bound or adsorbed thereto,wherein the colloidal silica particles containing a fluorescent dye compound have an average diameter of 30 nm or less, and wherein said silica particles are used simultaneously as fluorescent-labelling nanobeads; a fluorescent nano-material comprising said colloidal silica particles; and a biochip and an assay method using the same.
摘要翻译： 含有荧光染料化合物的胶体二氧化硅颗粒由含有二氧化硅组分的二氧化硅颗粒和化学键合或吸附的荧光染料化合物组成，其中含有荧光染料化合物的胶态二氧化硅颗粒的平均直径为30nm以下， 其中所述二氧化硅颗粒同时用作荧光标记纳米珠; 包含所述胶体二氧化硅颗粒的荧光纳米材料; 以及使用其的生物芯片和测定方法。
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公开(公告)号：US20080124806A1
公开(公告)日：2008-05-29
申请号：US11678885
申请日：2007-02-26
申请人： Kunihiro Noda , Ryo Asakura , Daisuke Saito , Tetsuhiko Isobe , Tomohiro Takagi , Hideki Aizawa , Michio Ohkubo
发明人： Kunihiro Noda , Ryo Asakura , Daisuke Saito , Tetsuhiko Isobe , Tomohiro Takagi , Hideki Aizawa , Michio Ohkubo
IPC分类号： G01N37/00
CPC分类号： G01N33/582 , B82Y15/00 , G01N33/585 , G01N33/588 , Y10T436/13
摘要： A fluorescent labeling reagent of the present invention includes an inorganic fluorescent particle and a material (A) having a material (B) of biological origin adsorbed or bound thereto. The inorganic fluorescent particle is integrated with the material (A) so as to form the reagent of the present invention. The inorganic fluorescent particle used in the present invention is capable of emitting light with a wavelength of 650 nm to 1600 nm in the infrared region or the near-infrared region which can be detected by means of Si-CCD or InGaAs-PD and can penetrate an H2O rich sample when excited by light with a wavelength of 650 nm or longer which has the shortest transparent wavelength of AlInGaP-LD including oxygen adsorption type hemoglobin used for DVDs etc.
摘要翻译： 本发明的荧光标记试剂包括无机荧光颗粒和具有吸附或结合生物学原料的材料（B）的材料（A）。 将无机荧光颗粒与材料（A）整合以形成本发明的试剂。 本发明中使用的无机荧光粒子能够通过Si-CCD或InGaAs-PD检测的红外区域或近红外区域发射波长为650nm〜1600nm的光，并能够穿透 当具有波长为650nm或更长的光，其具有包括用于DVD等的氧吸附型血红蛋白的AlInGaP-LD的最短透明波长激发时，富含H 2 O 2的样品。
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6.发明授权Colloidal silica particle containing light-absorbing substance, nano light-absorbing material, absorption labeling nanobead kit, and method for detection or quantification of biological molecule using the colloidal silica particle containing light-absorbing substance 有权含有光吸收物质的胶体二氧化硅粒子，纳米光吸收材料，吸收标记纳米棒试剂盒，以及使用含有光吸收物质的胶体二氧化硅粒子检测或定量生物分子的方法公开(公告)号：US07947461B2
公开(公告)日：2011-05-24
申请号：US12320998
申请日：2009-02-10
申请人： Hideki Aizawa , Michio Ohkubo
发明人： Hideki Aizawa , Michio Ohkubo
IPC分类号： G01N33/53
CPC分类号： G01N33/532 , G01N33/552 , G01N33/587 , Y10T428/2982
摘要： A colloidal silica particle containing a light-absorbing substance, comprising a colloidal silica particle and a light-absorbing substance distributed over the colloidal silica particle, wherein the light-absorbing substance is chemically bound to or adsorbed on a silica component.
摘要翻译： 一种含有光吸收物质的胶体二氧化硅颗粒，其包含胶体二氧化硅颗粒和分布在胶体二氧化硅颗粒上的光吸收物质，其中光吸收物质与二氧化硅组分化学键合或吸附。
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公开(公告)号：US07842505B2
公开(公告)日：2010-11-30
申请号：US11678885
申请日：2007-02-26
申请人： Kunihiro Noda , Ryo Asakura , Daisuke Saito , Tetsuhiko Isobe , Tomohiro Takagi , Hideki Aizawa , Michio Ohkubo
发明人： Kunihiro Noda , Ryo Asakura , Daisuke Saito , Tetsuhiko Isobe , Tomohiro Takagi , Hideki Aizawa , Michio Ohkubo
IPC分类号： G01N37/00 , G01N33/533 , G01N33/543 , G01N33/551 , C01F17/00 , G01N33/553
CPC分类号： G01N33/582 , B82Y15/00 , G01N33/585 , G01N33/588 , Y10T436/13
摘要： A fluorescent labeling reagent of the present invention includes an inorganic fluorescent particle and a material (A) having a material (B) of biological origin adsorbed or bound thereto. The inorganic fluorescent particle is integrated with the material (A) so as to form the reagent of the present invention. The inorganic fluorescent particle used in the present invention is capable of emitting light with a wavelength of 650 nm to 1600 nm in the infrared region or the near-infrared region which can be detected by means of Si—CCD or InGaAs—PD and can penetrate an H2O rich sample when excited by light with a wavelength of 650 nm or longer which has the shortest transparent wavelength of AlInGaP-LD including oxygen adsorption type hemoglobin used for DVDs etc.
摘要翻译： 本发明的荧光标记试剂包括无机荧光颗粒和具有吸附或结合生物学原料的材料（B）的材料（A）。 将无机荧光颗粒与材料（A）整合以形成本发明的试剂。 本发明中使用的无机荧光粒子能够通过Si-CCD或InGaAs-PD检测的红外区域或近红外区域发射波长为650nm〜1600nm的光，并能够穿透 当具有650nm或更长波长的光激发时，其具有包括用于DVD等的氧吸附型血红蛋白的AlInGaP-LD的最短透明波长的富H2O样品。
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8.发明申请Labelled silica nanoparticles for immunochromatographic reagent, immunochromatographic reagent, immunochromatographic test strip using the same, and immunochromatographic fluorescence-detecting system or radiation-detecting system 有权用于免疫色谱试剂的标记二氧化硅纳米颗粒，免疫色谱试剂，使用其的免疫色谱试纸和免疫色谱荧光检测系统或辐射检测系统公开(公告)号：US20090017561A1
公开(公告)日：2009-01-15
申请号：US12155622
申请日：2008-06-06
申请人： Hideki Aizawa , Michio Ohkubo
发明人： Hideki Aizawa , Michio Ohkubo
IPC分类号： G01N33/543 , B32B5/16
CPC分类号： G01N33/54366 , B82Y15/00 , G01N21/6428 , G01N21/77 , G01N33/54346 , G01N33/54353 , G01N33/552 , G01N33/587 , G01N2021/7753 , G01N2021/7759 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918 , Y10T428/2982
摘要： Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance.
摘要翻译： 用于免疫色谱试剂的标记二氧化硅纳米颗粒，包含含有标记物质的二氧化硅纳米颗粒。
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公开(公告)号：US07955866B2
公开(公告)日：2011-06-07
申请号：US12155622
申请日：2008-06-06
申请人： Hideki Aizawa , Michio Ohkubo
发明人： Hideki Aizawa , Michio Ohkubo
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , B82Y15/00 , G01N21/6428 , G01N21/77 , G01N33/54346 , G01N33/54353 , G01N33/552 , G01N33/587 , G01N2021/7753 , G01N2021/7759 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918 , Y10T428/2982
摘要： Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance.
摘要翻译： 用于免疫色谱试剂的标记二氧化硅纳米颗粒，包含含有标记物质的二氧化硅纳米颗粒。
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10.发明申请Collodial silica particle containing light-absorbing susbstance, nano light-absorbing material,absorption labeling nanobead kit, and method for detection or quantification of biological molecule using the colloidal silica particle containing light-absorbing substance 有权含有光吸收性物质的纳米吸光材料，吸收标记纳米涂片试剂盒和使用含有光吸收物质的胶体二氧化硅粒子检测或定量生物分子的方法公开(公告)号：US20090215096A1
公开(公告)日：2009-08-27
申请号：US12320998
申请日：2009-02-10
申请人： Hideki Aizawa , Michio Ohkubo
发明人： Hideki Aizawa , Michio Ohkubo
CPC分类号： G01N33/532 , G01N33/552 , G01N33/587 , Y10T428/2982
摘要： A colloidal silica particle containing a light-absorbing substance, comprising a colloidal silica particle and a light-absorbing substance distributed over the colloidal silica particle, wherein the light-absorbing substance is chemically bound to or adsorbed on a silica component.
摘要翻译： 一种含有光吸收物质的胶体二氧化硅颗粒，其包含胶体二氧化硅颗粒和分布在胶体二氧化硅颗粒上的光吸收物质，其中光吸收物质与二氧化硅组分化学键合或吸附。
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