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公开(公告)号：US20110269942A1
公开(公告)日：2011-11-03
申请号：US12672861
申请日：2008-08-04
申请人： Koji Morita , Takako Niwa , Yuji Kasuya , Kimihisa Ichikawa , Hiroko Yoshida
发明人： Koji Morita , Takako Niwa , Yuji Kasuya , Kimihisa Ichikawa , Hiroko Yoshida
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K9/127 , A61K47/6913 , C07K2317/73
摘要： The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
摘要翻译： 本发明涉及具有对癌症，自身免疫疾病或炎性疾病的治疗作用的免疫脂质体制剂或疏水性分子修饰抗体。 具体地说，本发明涉及一种免疫脂质体或疏水性分子修饰抗体，其包含能够诱导表达含有死亡结构域的受体的细胞凋亡的抗体作为组分。
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2.发明申请IMMUNOLIPOSOME INDUCING APOPTOSIS INTO CELL EXPRESSING DEATH DOMAIN-CONTAINING RECEPTOR 审中-公开免疫球蛋白诱导凋亡进入细胞表达死亡含域受体公开(公告)号：US20100209490A1
公开(公告)日：2010-08-19
申请号：US12672870
申请日：2008-08-04
申请人： Koji Morita , Takako Niwa , Kimihisa Ichikawa , Hiroko Yoshida
发明人： Koji Morita , Takako Niwa , Kimihisa Ichikawa , Hiroko Yoshida
IPC分类号： A61K9/127 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2878 , A61K9/127 , A61K47/6913 , C07K2317/73
摘要： The present invention relates to an immunoliposome preparation having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.
摘要翻译： 本发明涉及具有对癌症，自身免疫疾病或炎性疾病的治疗作用的免疫脂质体制剂。 具体地，本发明涉及包含能够诱导表达含有死亡结构域的受体的细胞凋亡的抗体作为组分的免疫脂质体。
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公开(公告)号：US06972323B1
公开(公告)日：2005-12-06
申请号：US09499662
申请日：2000-02-09
申请人： Nobufusa Serizawa , Kimihisa Ichikawa , Jun Ohsumi , Masahiko Ohtsuki , Hideyuki Haruyama , Tohru Takahashi , Hiroko Yoshida , Akio Shiraishi , Shin Yonehara
发明人： Nobufusa Serizawa , Kimihisa Ichikawa , Jun Ohsumi , Masahiko Ohtsuki , Hideyuki Haruyama , Tohru Takahashi , Hiroko Yoshida , Akio Shiraishi , Shin Yonehara
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： Anti-Fas antibodies which are cross-reactive with mouse and human Fas and are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system.
摘要翻译： 抗Fas抗体与小鼠和人Fas交叉反应，可用于治疗归因于Fas / Fas配体系统异常的病症。
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公开(公告)号：US06746673B2
公开(公告)日：2004-06-08
申请号：US09989620
申请日：2001-11-20
IPC分类号： A61K39395
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07C279/26 , C07D475/08 , C07K2317/73 , A61K31/00 , A61K2300/00
摘要： A pharmaceutical composition containing an anti-human Fas antibody having apoptosis inducing activity and a compound having a folate antagonist activity or a dihydrofolate reductase inhibiting activity, as active ingredients for the prophylaxis and/or treatment of an autoimmune disease or rheumatoid arthritis. According to the present invention, the amount of the anti-Fas antibody to be used can be reduced and thereby the possibility that a patient may become tolerant to anti-Fas antibody as a result of the production of antibodies against the anti-Fas antibody in the patient's body or the like can be decreased, and thus is provided a pharmaceutical composition which can be used for a long time.
摘要翻译： 含有具有凋亡诱导活性的抗人Fas抗体的药物组合物和具有叶酸拮抗剂活性或二氢叶酸还原酶抑制活性的化合物作为预防和/或治疗自身免疫性疾病或类风湿性关节炎的活性成分。 根据本发明，可以减少所使用的抗Fas抗体的量，从而由于抗Fas抗体产生抗体而导致患者可能耐受抗Fas抗体的可能性 可以减少患者的身体等，从而提供长时间使用的药物组合物。
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公开(公告)号：US20110070248A1
公开(公告)日：2011-03-24
申请号：US12889306
申请日：2010-09-23
申请人： Kimihisa Ichikawa , Kosaku Fujiwara , Hiroko Yoshida , Ayumi Yada
发明人： Kimihisa Ichikawa , Kosaku Fujiwara , Hiroko Yoshida , Ayumi Yada
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2878 , A61K47/6803 , A61K47/6849 , C07K2319/30
摘要： Ligand Drug Conjugates are provided having a DR5 binding moiety attached via linking groups and/or spacers to a therapeutic agent and are effective in treatment of various cancers.
摘要翻译： 配体药物缀合物具有通过连接基团和/或间隔基与治疗剂连接的DR5结合部分并且有效治疗各种癌症。
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6.发明授权
公开(公告)号：US5164840A
公开(公告)日：1992-11-17
申请号：US400190
申请日：1989-08-28
申请人： Akihisa Kawamura , Masaharu Matsumoto , Mitsuhiko Serikawa , Ryo Tagami , Katsuaki Sato , Hiroko Yoshida , Hikari Hashimoto
发明人： Akihisa Kawamura , Masaharu Matsumoto , Mitsuhiko Serikawa , Ryo Tagami , Katsuaki Sato , Hiroko Yoshida , Hikari Hashimoto
CPC分类号： G11B20/00992 , G11B27/007 , G11B27/107 , G11B27/322 , G11B27/34 , H04N9/802 , H04S1/007
摘要： Control codes for controlling processing of an audio signal by a sound field variation circuit to produce desired sound fields are recorded on a monaural track of a video tape concurrent with recording of video and audio signals, and can thereby be subsequently played back for producing sound fields which are respectively synchronized with video images.
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公开(公告)号：US5144673A
公开(公告)日：1992-09-01
申请号：US623619
申请日：1990-12-07
摘要： A reflection sound compression apparatus extracts and compresses, most appropriately with a physical evaluation value, an impulse response of a hall, etc. which is obtained by calculation and actual experiments to reflection sounds in a number required by a sound field controller by using a learning identification method.
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公开(公告)号：US5891682A
公开(公告)日：1999-04-06
申请号：US851634
申请日：1997-05-06
申请人： Hiroko Yoshida , James D. Regan
发明人： Hiroko Yoshida , James D. Regan
CPC分类号： G01J1/58 , G01N21/33 , Y10T436/143333
摘要： A device for measuring a total dose of biologically effective radiation is provided, in a specific embodiment, for measuring ultraviolet B radiation (UVB) in the wavelength range of 290-400 nm. X-radiation and high-energy particle radiation are also measurable with this device. The device includes a sample of DNA dried onto a plastic film, and the analysis method includes assaying for damage with the use of polymerase chain reaction and fluorescence techniques. The damage to the DNA is correlatable with dosage via a comparison with standardized calibration data.
摘要翻译： 在具体实施方案中，提供了用于测量波长范围为290-400nm的紫外线B辐射（UVB）的用于测量生物有效辐射总剂量的装置。 X射线和高能粒子辐射也可用该装置测量。 该装置包括在塑料膜上干燥的DNA样品，并且分析方法包括使用聚合酶链式反应和荧光技术测定损伤。 通过与标准化校准数据的比较，对DNA的损伤与剂量相关。
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公开(公告)号：US5670186A
公开(公告)日：1997-09-23
申请号：US530306
申请日：1995-10-03
申请人： Koichi Nishimura , Hideki Koyama , Hiroko Yoshida , Susumu Ito
发明人： Koichi Nishimura , Hideki Koyama , Hiroko Yoshida , Susumu Ito
CPC分类号： B29C45/1774 , B29C2037/906 , Y10S425/045
摘要： An injection molding machine provided with an easy-to-operate and space-saving display unit, a clamping unit and an injection unit arranged laterally. The display unit is installed on an injection-side gate enclosing the injection unit. The display unit is movable as the injection-side gate is opened or closed, to simultaneously observe both the mold clamping-side gate and the display unit. Alternatively, the display unit is installed on an injection-side gate enclosing the clamping unit.
摘要翻译： PCT No.PCT / JP95 / 00101 Sec。 371 1995年10月3日第 102（e）日期1995年10月3日PCT 1995年1月27日PCT PCT。 公开号WO95 / 23059 日期1995年8月31日注射成型机设置有易于操作和节省空间的显示单元，夹持单元和横向布置的注射单元。 显示单元安装在包围注射单元的注射侧门上。 当注射侧门打开或关闭时，显示单元可移动，以同时观察模具夹紧侧门和显示单元。 或者，显示单元安装在包围夹紧单元的注射侧门上。
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10.发明授权Cell activator, collagen production promoter, skin whitening agent, antioxidant agent, antiinflammatory agent, aromatase activity promoter, protease activity promoter, external preparation for skin, and food 有权细胞活化剂，胶原蛋白生成促进剂，皮肤增白剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用剂和食品公开(公告)号：US07794759B2
公开(公告)日：2010-09-14
申请号：US12373725
申请日：2007-09-04
IPC分类号： A61K36/00
CPC分类号： A61K8/97 , A23L33/105 , A23V2002/00 , A61K2800/522 , A61Q19/02 , A61Q19/08 , A23V2250/21
摘要： The present invention provides a cell activation agent, a collagen production accelerator, a whitening agent, an antioxidant, an anti-inflammatory agent, an aromatase activity accelerator, a protease activity accelerator, a skin external preparation, and food, which all contain an extract of Hibiscus makinoi.
摘要翻译： 本发明提供一种细胞活化剂，胶原产生促进剂，增白剂，抗氧化剂，抗炎剂，芳香酶活性促进剂，蛋白酶活性促进剂，皮肤外用剂和食品，它们都含有提取物 的木槿。
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