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1.发明申请D-AMINO ACID OXIDASE, AND METHOD FOR PRODUCTION OF L-AMINO ACID, 2-OXO ACID, OR CYCLIC IMINE 有权D-氨基酸氧化物及其制备L-氨基酸，2-氧代酸或环状体的方法公开(公告)号：US20110086396A1
公开(公告)日：2011-04-14
申请号：US11997861
申请日：2006-08-02
申请人： Hiroyuki Kanamaru , Makoto Ueda , Ruuji Miki , Hirokazu Nanba
发明人： Hiroyuki Kanamaru , Makoto Ueda , Ruuji Miki , Hirokazu Nanba
CPC分类号： C12P7/40 , C12N9/0024 , C12P13/04 , C12P17/10
摘要： The present invention relates to novel D-amino acid oxidase isolated and purified from Candida intermedia, a gene encoding the D-amino acid oxidase, a recombinant plasmid containing the gene, and a transformant into which the D-amino acid oxidase gene has been introduced, as well as a production method of D-amino acid oxidase including culturing the transformant. Moreover, the present invention relates to a production method of L-amino acids, 2-oxo acids or cyclic imines, which include reacting racemic amino acids with the D-amino acid oxidase, more preferably, a production method of L-amino acids, which includes reacting racemic amino acid with the D-amino acid oxidase, amino acid dehydrogenase and an enzyme having a coenzyme-regenerating activity. According to the present invention, L-amino acids, 2-oxo acids or cyclic imines can be produced with good efficiency in an industrial scale.
摘要翻译： 本发明涉及从念珠菌中间体分离纯化的新型D-氨基酸氧化酶，编码D-氨基酸氧化酶的基因，含有该基因的重组质粒，以及引入了D-氨基酸氧化酶基因的转化体 以及D-氨基酸氧化酶的制造方法，包括培养转化体。 此外，本发明涉及L-氨基酸，2-氧酸或环状亚胺的制造方法，其包括使外消旋氨基酸与D-氨基酸氧化酶反应，更优选L-氨基酸的制造方法， 其包括使外消旋氨基酸与D-氨基酸氧化酶，氨基酸脱氢酶和具有辅酶再生活性的酶反应。 根据本发明，可以以工业规模高效率地制备L-氨基酸，2-氧代酸或环状亚胺。
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公开(公告)号：US4983391A
公开(公告)日：1991-01-08
申请号：US391043
申请日：1989-08-09
IPC分类号： A01N47/12
CPC分类号： A01N47/12
摘要： An insecticide for protecting a fibrous material from the damage by an insect, which comprises a carbamic ester of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a lower alkyl group and R.sub.3 is a lower alkyl group as an active ingredient.
摘要翻译： 一种用于保护纤维材料免受昆虫损伤的杀虫剂，其包含下式的氨基甲酸酯：其中R 1和R 2各自为氢原子或低级烷基，R 3为 低级烷基作为活性成分。
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公开(公告)号：US09273332B2
公开(公告)日：2016-03-01
申请号：US12445233
申请日：2007-10-11
申请人： Hiroyuki Kanamaru , Makoto Ueda , Hirokazu Nanba
发明人： Hiroyuki Kanamaru , Makoto Ueda , Hirokazu Nanba
CPC分类号： C12P13/06 , C12N9/0008 , C12N9/0073 , C12P13/04 , C12P13/08 , C12P13/222
摘要： The present invention has its object to provide a method for producing an L-amino acid comprising reacting a keto acid with an amino acid dehydrogenase and an enzyme having coenzyme regenerating ability to convert to a L-amino acid, wherein a coenzyme is added in two or more portions in the reaction. The method of the present invention enables efficient production of an L-amino acid useful as a synthetic intermediate such as a pharmaceutical intermediate with high optical purity by an enzymatic reductive amination independent of the purity of the keto acid used as a substrate.
摘要翻译： 本发明的目的是提供一种生产L-氨基酸的方法，其包括使酮酸与氨基酸脱氢酶和具有辅酶再生能力的酶反应以转化为L-氨基酸，其中将辅酶加入二 或更多的部分。 本发明的方法可以独立于用作底物的酮酸的纯度，有效地生产可用作合成中间体的L-氨基酸，例如具有高光学纯度的药物中间体，通过酶还原胺化。
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公开(公告)号：US20100028959A1
公开(公告)日：2010-02-04
申请号：US12445233
申请日：2007-10-11
申请人： Hiroyuki Kanamaru , Makoto Ueda , Hirokazu Nanba
发明人： Hiroyuki Kanamaru , Makoto Ueda , Hirokazu Nanba
CPC分类号： C12P13/06 , C12N9/0008 , C12N9/0073 , C12P13/04 , C12P13/08 , C12P13/222
摘要： The present invention has its object to provide a method for producing an L-amino acid comprising reacting a keto acid with an amino acid dehydrogenase and an enzyme having coenzyme regenerating ability to convert to a L-amino acid, wherein a coenzyme is added in two or more portions in the reaction. The method of the present invention enables efficient production of an L-amino acid useful as a synthetic intermediate such as a pharmaceutical intermediate with high optical purity by an enzymatic reductive amination independent of the purity of the keto acid used as a substrate.
摘要翻译： 本发明的目的是提供一种生产L-氨基酸的方法，其包括使酮酸与氨基酸脱氢酶和具有辅酶再生能力的酶反应以转化为L-氨基酸，其中将辅酶加入二 或更多的部分。 本发明的方法可以独立于用作底物的酮酸的纯度，有效地生产可用作合成中间体的L-氨基酸，例如具有高光学纯度的药物中间体，通过酶还原胺化。
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公开(公告)号：US4912137A
公开(公告)日：1990-03-27
申请号：US217853
申请日：1988-07-12
摘要： An insecticide which comprises an oxalic ester of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group but at least one of them is a C.sub.1 -C.sub.4 alkyl group.
摘要翻译： 一种杀虫剂，其包含下式的草酸酯：其中R 1和R 2各自为氢原子或C 1 -C 4烷基，但其中至少一个为C 1 -C 4烷基。
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6.发明授权Amino acid dehydrogenase, and process for producing L-amino acid, 2-oxo acid or D-amino acid 有权氨基酸脱氢酶，以及L-氨基酸，2-氧代酸或D-氨基酸的制备方法公开(公告)号：US09267116B2
公开(公告)日：2016-02-23
申请号：US13133444
申请日：2009-12-08
IPC分类号： C12N9/06 , C12N1/21 , C12P13/04 , C07H21/04 , C12P7/40 , C12P13/22 , C12P41/00 , C12N15/70 , C12N15/74
CPC分类号： C12N9/0016 , C12N9/0012 , C12N15/70 , C12N15/74 , C12P7/40 , C12P13/04 , C12P13/22 , C12P41/006
摘要： The present invention relates to a novel amino acid dehydrogenase, DNA encoding the enzyme, and a transformant having the DNA introduced therein. The present invention also relates to a process for producing an L-amino acid, 2-oxo acid or D-amino acid, which includes allowing the amino acid dehydrogenase or a microorganism or transformant capable of producing the enzyme to act on a substrate compound. The amino acid dehydrogenase has good reactivity even with an amino acid or a 2-oxo acid each having a bulky side chain such as an aromatic-ring-containing group, which acids are poorly reactive with conventional amino acid dehydrogenases. The amino acid dehydrogenase enables the inexpensive and highly efficient production of a useful optically active amino acid.
摘要翻译： 本发明涉及新的氨基酸脱氢酶，编码该酶的DNA，以及引入其中的DNA的转化体。 本发明还涉及生产L-氨基酸，2-氧代酸或D-氨基酸的方法，其包括使氨基酸脱氢酶或能够产生酶的微生物或转化体作用于底物化合物。 氨基酸脱氢酶即使对于具有大的侧链的氨基酸或2-氧代酸，例如含芳香环的基团，该酸与常规氨基酸脱氢酶的反应性差。 氨基酸脱氢酶能够廉价且高效地生产有用的光学活性氨基酸。
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7.发明授权D-amino acid oxidase, and method for production of L-amino acid, 2-oxo acid, or cyclic imine 有权D-氨基酸氧化酶，以及L-氨基酸，2-氧代酸或环状亚胺的制备方法公开(公告)号：US08227228B2
公开(公告)日：2012-07-24
申请号：US11997861
申请日：2006-08-02
申请人： Hiroyuki Kanamaru , Makoto Ueda , Ryuuji Miki , Hirokazu Nanba
发明人： Hiroyuki Kanamaru , Makoto Ueda , Ryuuji Miki , Hirokazu Nanba
CPC分类号： C12P7/40 , C12N9/0024 , C12P13/04 , C12P17/10
摘要： The present invention relates to novel D-amino acid oxidase isolated and purified from Candida intermedia, a gene encoding the D-amino acid oxidase, a recombinant plasmid containing the gene, and a transformant into which the D-amino acid oxidase gene has been introduced, as well as a production method of D-amino acid oxidase including culturing the transformant. Moreover, the present invention relates to a production method of L-amino acids, 2-oxo acids or cyclic imines, which include reacting racemic amino acids with the D-amino acid oxidase, more preferably, a production method of L-amino acids, which includes reacting racemic amino acid with the D-amino acid oxidase, amino acid dehydrogenase and an enzyme having a coenzyme-regenerating activity. According to the present invention, L-amino acids, 2-oxo acids or cyclic imines can be produced with good efficiency in an industrial scale.
摘要翻译： 本发明涉及从念珠菌中间体分离纯化的新型D-氨基酸氧化酶，编码D-氨基酸氧化酶的基因，含有该基因的重组质粒，以及引入了D-氨基酸氧化酶基因的转化体 以及D-氨基酸氧化酶的制造方法，包括培养转化体。 此外，本发明涉及L-氨基酸，2-氧酸或环状亚胺的制造方法，其包括使外消旋氨基酸与D-氨基酸氧化酶反应，更优选L-氨基酸的制造方法， 其包括使外消旋氨基酸与D-氨基酸氧化酶，氨基酸脱氢酶和具有辅酶再生活性的酶反应。 根据本发明，可以以工业规模高效率地制备L-氨基酸，2-氧代酸或环状亚胺。
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8.发明申请NOVEL AMINO ACID DEHYDROGENASE, AND PROCESS FOR PRODUCING L-AMINO ACID, 2-OXO ACID OR D-AMINO ACID 有权新型氨基酸脱氢酶，以及生产L-氨基酸，2-氧代酸或D-氨基酸的方法公开(公告)号：US20110281309A1
公开(公告)日：2011-11-17
申请号：US13133444
申请日：2009-12-08
CPC分类号： C12N9/0016 , C12N9/0012 , C12N15/70 , C12N15/74 , C12P7/40 , C12P13/04 , C12P13/22 , C12P41/006
摘要： The present invention relates to a novel amino acid dehydrogenase, DNA encoding the enzyme, and a transformant having the DNA introduced therein. The present invention also relates to a process for producing an L-amino acid, 2-oxo acid or D-amino acid, which includes allowing the amino acid dehydrogenase or a microorganism or transformant capable of producing the enzyme to act on a substrate compound. The amino acid dehydrogenase has good reactivity even with an amino acid or a 2-oxo acid each having a bulky side chain such as an aromatic-ring-containing group, which acids are poorly reactive with conventional amino acid dehydrogenases. The amino acid dehydrogenase enables the inexpensive and highly efficient production of a useful optically active amino acid.
摘要翻译： 本发明涉及新的氨基酸脱氢酶，编码该酶的DNA，以及引入其中的DNA的转化体。 本发明还涉及生产L-氨基酸，2-氧代酸或D-氨基酸的方法，其包括使氨基酸脱氢酶或能够产生酶的微生物或转化体作用于底物化合物。 氨基酸脱氢酶即使对于具有大的侧链的氨基酸或2-氧代酸，例如含芳香环的基团，该酸与常规氨基酸脱氢酶的反应性差。 氨基酸脱氢酶能够廉价且高效地生产有用的光学活性氨基酸。
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公开(公告)号：US5244985A
公开(公告)日：1993-09-14
申请号：US857247
申请日：1992-03-25
申请人： Tomio Nobe , Hiroyuki Kanamaru , Harutomo Nomoto , Shoji Tani
发明人： Tomio Nobe , Hiroyuki Kanamaru , Harutomo Nomoto , Shoji Tani
CPC分类号： C08G59/027 , C08G63/918
摘要： Disclosed are an epoxidized polyester which comprises, per molecule, at least three bifunctional groups each having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms, or R.sup.1 and R.sup.2 taken together represent an endomethylene group, and which has a number average molecular weight of about 1,000 to about 10,000, as well as processes for preparing the epoxidized polyester.
摘要翻译： 公开了一种环氧化聚酯，其每分子包含至少三个具有通式（I）的双官能团，其中R 1和R 2相同或不同，并且各自为氢原子或含有1至5个的烷基 碳原子，或者R 1和R 2一起表示内亚甲基，其数均分子量为约1,000至约10,000，以及制备环氧化聚酯的方法。
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