FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND APPLICATION THEREOF
    4.
    发明申请
    FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND APPLICATION THEREOF 有权
    荧光探针化合物,其制备方法和应用

    公开(公告)号:US20120288947A1

    公开(公告)日:2012-11-15

    申请号:US13521047

    申请日:2010-12-06

    IPC分类号: G01N21/76 C07D491/107

    摘要: The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2 in near-neutral pH range. In detection of Pd2 in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2 in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2 concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.

    摘要翻译: 本发明公开了一种解决Pd2 +荧光猝灭问题的荧光探针化合物及其制备方法和用途。 探针化合物的激发和发射波长处于可见光区域。 探针化合物是高度敏感的,对近中性pH范围内的Pd2显示出良好的选择性。 在检测到0-10ppb级别的Pd2时,荧光显着增强,可以检测到低至5nM的Pd2。 荧光强度与Pd2浓度呈线性相关。 探针化合物可用于检测药物,土壤,水样和反应器中污染的钯和残留的钯。