公开(公告)号：US08134007B2

公开(公告)日：2012-03-13

申请号：US12114258

申请日：2008-05-02

Applicant: Sharanjeet Kaur Bagal ,  Karl Richard Gibson ,  Mark Ian Kemp ,  Cedric Poinsard ,  Blanda Luzia Stammen ,  Stephen Martin Denton ,  Melanie Susanne Glossop

Inventor： Sharanjeet Kaur Bagal ,  Karl Richard Gibson ,  Mark Ian Kemp ,  Cedric Poinsard ,  Blanda Luzia Stammen ,  Stephen Martin Denton ,  Melanie Susanne Glossop

IPC: C07D413/12 ,  C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439

CPC classification number: C07D401/12 ,  C07D213/75 ,  C07D413/12

Abstract: The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，用于制备用于制备中间体的方法和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。

公开(公告)号：US06794387B2

公开(公告)日：2004-09-21

申请号：US10099264

申请日：2002-03-14

Applicant: Charlotte Moira Norfor Allerton ,  Kevin Neil Dack ,  Mark Ian Kemp

Inventor： Charlotte Moira Norfor Allerton ,  Kevin Neil Dack ,  Mark Ian Kemp

IPC: C07D48704

CPC classification number: C07D487/04

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, X, Y and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.

Abstract translation: 通式（I）的化合物：其中R 1，R 2，R 3，R 4，X，Y和A具有本文给出的用于治疗和预防性治疗 需要抑制环鸟苷3'，5'-单磷酸磷酸二酯酶（如cGMP PDE5）的医疗条件。

公开(公告)号：US06668748B2

公开(公告)日：2003-12-30

申请号：US10087532

申请日：2002-03-01

Applicant: Nicholas Ian Kemp ,  Robert Murdoch Mackie ,  Ian Robert Mackie

Inventor： Nicholas Ian Kemp ,  Robert Murdoch Mackie ,  Ian Robert Mackie

IPC: B63G800

CPC classification number: B63B3/13 ,  B63B2231/50

Abstract: A submersible article comprises a buoyancy body formed from polyurethane foam having a first density, which is at least partly overmolded with a protective skin of polyurethane foam having a second density higher than the first density. The lower density foam of the body gives the article buoyancy, while the higher density protective skin strengthens the article and gives impact resistance. The protective skin can be stiffened, either uniformly or locally, by the addition of glass fiber or other reinforcing material which is arranged over the buoyancy body prior to the overmolding. The article can be made by a two-stage molding process.

Abstract translation: 潜水制品包括由具有第一密度的聚氨酯泡沫形成的浮力体，所述浮力体具有第二密度高于第一密度的聚氨酯泡沫的保护表面至少部分地包覆成型。 身体的较低密度泡沫使得物品浮力，而较高密度的保护皮肤增强了制品并提供了抗冲击性。 保护性皮肤可以均匀地或局部地加固，通过添加玻璃纤维或其它增强材料，该材料在包覆成型之前布置在浮力体上。 该制品可以通过两阶段成型工艺制成。

公开(公告)号：USD301022S

公开(公告)日：1989-05-09

申请号：US891386

申请日：1986-07-31

Applicant: Ian Kemp

Designer： Ian Kemp

公开(公告)号：USD284179S

公开(公告)日：1986-06-10

申请号：US584349

申请日：1984-02-28

Applicant: Ian Kemp

Designer： Ian Kemp

公开(公告)号：US4351382A

公开(公告)日：1982-09-28

申请号：US212143

申请日：1980-12-02

Applicant: Michael R. Corner ,  Ian Kemp ,  Tom French

Inventor： Michael R. Corner ,  Ian Kemp ,  Tom French

IPC: B60B21/02 ,  B60B21/10 ,  B60C15/02 ,  B60C15/024 ,  B60C5/16

CPC classification number: B60B21/10 ,  B60C15/02 ,  B60C15/0226 ,  B60C15/024 ,  Y10S152/09

Abstract: A tire and wheel rim assembly having improved bead retention characteristics when run deflated.One or both bead seats is substantially straight and provided with an abutment respectively which is substantially continuous in the circumferential direction. Each abutment has a maximum radial dimension less than the minimum diameter of the tire bead reinforcement to allow fitment of the tire to a one-piece rim having a tire fitting well by conventional techniques. The taper of the bead seats is selected to enable abutments to be provided which have sufficient radial dimension or height relative to the adjacent bead seat such that under the action of road generated forces rotation of the tire beads about the adjacent abutment is effected to retain the tire beads at the bead seats.

Abstract translation: 一种轮胎和轮辋组件，其在运行放气时具有改善的胎圈保持特性。 一个或两个胎圈座基本上是直的并且分别设置有在圆周方向上基本上连续的邻接件。 每个支座具有小于轮胎胎圈加强件的最小直径的最大径向尺寸，以允许轮胎通过常规技术将轮胎装配到具有轮胎配合的单件轮辋。 选择胎圈座的锥度使得能够提供具有相对于相邻胎圈座具有足够的径向尺寸或高度的基台，使得在道路产生的作用下，轮胎胎圈围绕相邻邻接部的旋转被实现以保持 轮胎珠在珠子座上。

公开(公告)号：US4325422A

公开(公告)日：1982-04-20

申请号：US103390

申请日：1979-12-13

Applicant: Michael R. Corner ,  Ian Kemp ,  Barrie J. Allbert ,  Tom French

Inventor： Michael R. Corner ,  Ian Kemp ,  Barrie J. Allbert ,  Tom French

IPC: B60B21/12 ,  B60B21/02 ,  B60B21/10 ,  B60C3/00 ,  B60C15/02 ,  B60B21/00

CPC classification number: B60B21/10 ,  B60C15/0226 ,  Y10S152/09 ,  Y10S152/17

Abstract: A pneumatic tire and wheel rim assembly is disclosed in which the rim bead seats are defined by grooves having radially directed side portions which retain the associated tire bead against movement in an axial direction and each rim bead seat includes means in engagement with the tire bead to restrict rotation of the tire bead relative to the bead seat. Preferably said means comprises a plurality of projections formed integrally with part or all of the grooves which engage the associated tire bead to restrict rotation. Each projection may comprise a circumferentially extending rib or a tooth.

Abstract translation: 公开了一种充气轮胎和轮辋组件，其中轮辋胎圈座由具有径向指向侧部分的槽限定，所述槽具有径向指向的侧部，该侧部保持相关联的胎圈抵抗轴向移动，并且每个胎圈座包括与轮胎胎圈接合的装置 限制轮胎胎圈相对于胎圈座的旋转。 优选地，所述装置包括与部分或全部凹槽一体形成的多个突起，其与相关联的轮胎胎圈接合以限制旋转。 每个突起可以包括周向延伸的肋或齿。

公开(公告)号：US06372736B1

公开(公告)日：2002-04-16

申请号：US09358107

申请日：1999-07-21

Applicant: Mark Ian Kemp ,  Michael John Palmer ,  Mark Allen Sanner ,  Martin James Wythes

Inventor： Mark Ian Kemp ,  Michael John Palmer ,  Mark Allen Sanner ,  Martin James Wythes

IPC: A01N4346

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Compounds of the formula (I): wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.

Abstract translation: 式（I）化合物：其中A，Y，R，X，R 1，R 2，R 3和R 4如上定义，是旋转异构酶特别是FKBP-12和FKBP-52的抑制剂。 因此，所述化合物适度地进行神经元再生和生长，并可用于治疗由神经变性疾病或涉及神经损伤的其它疾病引起的神经障碍。

公开(公告)号：USD305220S

公开(公告)日：1989-12-26

申请号：US891385

申请日：1986-07-31

Applicant: Ian Kemp

Designer： Ian Kemp

公开(公告)号：US20100227872A1

公开(公告)日：2010-09-09

申请号：US12598308

申请日：2008-04-21

Applicant: Mark Ian Kemp

Inventor： Mark Ian Kemp

IPC: A61K31/497 ,  C07D413/12 ,  C07D403/12 ,  A61P29/00

CPC classification number: C07D413/12 ,  C07D403/12

Abstract: The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.

Abstract translation: 本发明涉及下式的化合物及其药学上可接受的盐和溶剂化物，其制备方法，用于制备的中间体和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。