公开(公告)号：US20220168395A1

公开(公告)日：2022-06-02

申请号：US17677589

申请日：2022-02-22

申请人： Cytune Pharma ,  Institut Gustave Roussy (IGR)

发明人： David Bechard ,  Nathalie Chaput ,  Melanie Desbois

IPC分类号： A61K38/20 ,  C07K16/28 ,  C07K14/715 ,  A61K39/395 ,  C07K14/54 ,  A61K9/00 ,  A61K38/17 ,  C07K16/30

摘要： The present disclosure relates to a combined pharmaceutical composition, adapted for simultaneous, separate, or sequential administration for treating cancer in a subject comprising (a) a conjugate comprising (i) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and ii) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Ra or derivatives thereof; a polynucleotide coding therefore, or a vector comprising such a polynucleotide; and (b) an antibody antagonizing an immune pathway implicated in the inhibition of T cell activation, or a fragment thereof, a polynucleotide coding therefore, or a vector comprising such a polynucleotide.

公开(公告)号：US20240093233A1

公开(公告)日：2024-03-21

申请号：US18261051

申请日：2022-01-13

申请人： VIROXIS ,  INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT GUSTAVE ROUSSY (IGR)

发明人： Thierry HEIDMANN ,  Frederic TANGY

IPC分类号： C12N15/86 ,  A61P31/18 ,  C07K14/15 ,  C12N7/00

CPC分类号： C12N15/86 ,  A61P31/18 ,  C07K14/15 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2760/18422 ,  C12N2760/18443 ,  C12N2770/24122

摘要： The invention relates to recombinant measles virus expressing Immunodeficiency virus (IV) or HTLV polypeptides, and concerns in particular immunogenic immunodeficiency virus particles expressed by a measles virus and/or virus like particles (VLPs) that contain proteins of at least one immunodeficiency virus or Human T-lymphotropic virus. These particles may be recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acid constructs, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by HIV or HTLV.

公开(公告)号：US20220202904A1

公开(公告)日：2022-06-30

申请号：US17695688

申请日：2022-03-15

申请人： Cytune Pharma ,  Institut Gustave Roussy (IGR)

发明人： David Bechard ,  Nathalie Chaput ,  Melanie Desbois

IPC分类号： A61K38/20 ,  C07K16/30 ,  A61K39/395 ,  A61K38/17 ,  C07K14/715 ,  A61K9/00 ,  C07K16/28 ,  C07K14/54

摘要： The present invention relates to a combined pharmaceutical composition, adapted for simultaneous, separate, or sequential administration for treating cancer in a subject comprising (a) a conjugate comprising (i) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and ii) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; a polynucleotide coding therefore, or a vector comprising such a polynucleotide; and (b) an antibody antagonizing an immune pathway implicated in the inhibition of T cell activation, or a fragment thereof, a polynucleotide coding therefore, or a vector comprising such a polynucleotide.

公开(公告)号：US20040191230A1

公开(公告)日：2004-09-30

申请号：US10740266

申请日：2003-12-18

申请人： Bioalliance Pharma, a corporation of France ,  Ecole Normale Superieure de Cachan, a corporation of France ,  Institut Gustave Roussy - IGR, a corporation of France ,  Centre National de la Recherche Scientifique - CNRS, a corporation of France

发明人： Christian Auclair ,  Valerie Amsellem ,  Martial Hervy ,  Frederic Subra

IPC分类号： A61K048/00

CPC分类号： C12N15/113 ,  C07K14/47

摘要： A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.

摘要翻译： 用于治疗，预防或诊断肿瘤病理学的药物组合物，其包含稳定细胞骨架肌动蛋白网络的活性剂。

公开(公告)号：US20230183306A1

公开(公告)日：2023-06-15

申请号：US17876987

申请日：2022-07-29

申请人： Cytune Pharma ,  Institut Gustave Roussy (IGR)

发明人： David Bechard ,  Nathalie Chaput ,  Melanie Desbois

IPC分类号： C07K14/54 ,  A61K38/20 ,  G01N33/50 ,  A61K47/64 ,  C07K14/715

CPC分类号： C07K14/5443 ,  A61K38/20 ,  G01N33/5047 ,  G01N33/5011 ,  A61K47/642 ,  C07K14/7155 ,  G01N2800/52 ,  C07K2319/00

摘要： The present invention relates to a pharmaceutical composition for treating a cancer or an infection in a subject by administrating an amount of an IL-15 derivative conjugate so as to induce a proliferation of natural killer cells (NK cells) which is the same or higher than the one obtained with high dose of interleukin-2 (HDIL-2); eventually associated with a pharmaceutically acceptable carrier.

公开(公告)号：US20160068584A1

公开(公告)日：2016-03-10

申请号：US14785536

申请日：2014-04-22

申请人： CYTUNE PHARMA ,  INSTITUT GUSTAVE ROUSSY (IGR)

发明人： David Bechard ,  Nathalie Chaput ,  Melanie Desbois

IPC分类号： C07K14/54 ,  C07K14/715

CPC分类号： C07K14/5443 ,  A61K38/20 ,  A61K47/642 ,  C07K14/7155 ,  C07K2319/00 ,  G01N33/5011 ,  G01N33/5047 ,  G01N2800/52

摘要： The present invention relates to a pharmaceutical composition for treating a cancer or an infection in a subject by administrating an amount of an IL-15 derivative conjugate so as to induce a proliferation of natural killer cells (NK cells) which is the same or higher than the one obtained with high dose of interleukin-2 (HDIL-2); eventually associated with a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及通过施用一定量的IL-15衍生物缀合物来诱导受试者的癌症或感染的药物组合物，以诱导相同或更高的天然杀伤细胞（NK细胞）的增殖 用高剂量的白介素-2（HDIL-2）获得的; 最终与药学上可接受的载体相关联。

公开(公告)号：US20040171551A1

公开(公告)日：2004-09-02

申请号：US10803366

申请日：2004-03-18

申请人： Institut Gustave Roussy - IGR, a corporation of France ,  Universite Paris-Sud, a corporation of France

发明人： Frederic Triebel

IPC分类号： A61K038/16 ,  A61K038/10 ,  C07K014/47

CPC分类号： C07K14/47 ,  C12N2799/021

摘要： A molecule binding to a target including an EP motif having the following sequence: (X-(EP)n-Y-(EP)m-Z)p wherein X, Y and Z may be identical or different and include a sequence of 0 to 10 amino acids, identical or different, n and m are integers between 0 to 20, preferably between 3 to 10, with at least one of n or m being different from 0, and p is an integer between 1 and 10.

摘要翻译： 结合靶的分子，其包含具有以下序列的EP基序：（X-（EP）nY-（EP）mZ）p其中X，Y和Z可以相同或不同，并且包括0至10个氨基酸的序列 相同或不同，n和m是0至20，优选3至10之间的整数，n或m中的至少一个不同于0，p是1至10之间的整数。