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    Mixture of Peptides Derived from E6 and/or E7 Papillomavirus Proteins and Uses Thereof
    3.
    发明申请
    Mixture of Peptides Derived from E6 and/or E7 Papillomavirus Proteins and Uses Thereof 审中-公开
    衍生自E6和/或E7乳头瘤病毒蛋白质的肽的混合物及其用途

    公开(公告)号：US20100203080A1

    公开(公告)日：2010-08-12

    申请号：US12347471

    申请日：2008-12-31

    申请人： Bernard Maillere ,  Isabelle Bourgault-Villada ,  Sandra Pouvelle-Moratille ,  Jean-Gerard Guillet

    发明人： Bernard Maillere ,  Isabelle Bourgault-Villada ,  Sandra Pouvelle-Moratille ,  Jean-Gerard Guillet

    IPC分类号： A61K39/12 ,  C07K7/08 ,  C07K14/025 ,  A61K39/295 ,  A61P31/20 ,  C12N5/0783 ,  C12Q1/02

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/58 ,  C12N2710/20022 ,  C12N2710/20034 ,  G01N33/505 ,  G01N2333/025 ,  Y02A50/412

    摘要： The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.

    摘要翻译： 本发明涉及衍生自参与子宫颈宫颈例如HPV16，HPV18，HPV30，HPV31，HPV32，HPV33，HPV34，HPV35，HPV39，HPV40，HPV42等的乳头瘤病毒的E6和/或E7蛋白的肽的混合物。 HPV43，HPV44，HPV45，HPV51，HPV52，HPV56，HPV57和HPV58，以及其作为药物的用途（在免疫原性组合物中，能够在体内刺激抗HPV T CD4 +淋巴细胞的产生，因此可用于 针对子宫癌和其他癌症子宫的接种）或作为HPV特异性T淋巴细胞的诊断试剂，特别是用于评估患者的免疫状况。 本发明还涉及衍生自涉及良性皮肤病变（例如疣），例如HPV10，HPV3或HPV4的乳头瘤病毒的E6和/或E7蛋白的肽的混合物及其作为药物的用途。

    Mixture of peptides derived from E6 and/or E7 papillomavirus proteins and uses thereof
    4.
    发明授权
    Mixture of peptides derived from E6 and/or E7 papillomavirus proteins and uses thereof 有权
    衍生自E6和/或E7乳头瘤病毒蛋白质的肽的混合物及其用途

    公开(公告)号：US07488791B2

    公开(公告)日：2009-02-10

    申请号：US10476570

    申请日：2002-05-03

    申请人： Bernard Maillere ,  Isabelle Bourgault-Villada ,  Sandra Pouvelle-Moratille ,  Jean-Gérard Guillet

    发明人： Bernard Maillere ,  Isabelle Bourgault-Villada ,  Sandra Pouvelle-Moratille ,  Jean-Gérard Guillet

    IPC分类号： A61K38/00

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/58 ,  C12N2710/20022 ,  C12N2710/20034 ,  G01N33/505 ,  G01N2333/025

    摘要： The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.

    摘要翻译： 本发明涉及衍生自参与子宫颈宫颈例如HPV16，HPV18，HPV30，HPV31，HPV32，HPV33，HPV34，HPV35，HPV39，HPV40，HPV42等的乳头瘤病毒的E6和/或E7蛋白的肽的混合物。 HPV43，HPV44，HPV45，HPV51，HPV52，HPV56，HPV57和HPV58，以及其作为药物的用途（在免疫原性组合物中，能够在体内刺激抗HPV T CD4 +淋巴细胞的产生，因此可用于 针对子宫癌和其他癌症子宫的接种）或作为HPV特异性T淋巴细胞的诊断试剂，特别是用于评估患者的免疫状况。 本发明还涉及衍生自涉及良性皮肤病变（例如疣），例如HPV10，HPV3或HPV4的乳头瘤病毒的E6和/或E7蛋白的肽的混合物及其作为药物的用途。