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公开(公告)号:US09248179B2
公开(公告)日:2016-02-02
申请号:US13806622
申请日:2011-06-23
申请人: Xianfu Wu , Charles E. Rupprecht , Ivan V. Kuzmin
发明人: Xianfu Wu , Charles E. Rupprecht , Ivan V. Kuzmin
IPC分类号: A61K39/205 , A61K39/12 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号: A61K39/205 , A61K39/12 , A61K2039/5256 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/20121 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143 , C12N2760/20152 , C12N2800/50
摘要: Described herein are recombinant rabies viruses encoding rabies virus glycoprotein and at least one heterologous glycoprotein from another lyssavirus, such as Mokola virus, Lagos bat virus and/or West Caucasian bat virus. In particular embodiments, the recombinant rabies virus includes two or three heterologous lyssavirus glycoproteins. The disclosed recombinant rabies viruses can be used as pan-lyssavirus vaccines to provide protection against lyssaviruses that cause rabies.
摘要翻译: 本文描述的是编码狂犬病病毒糖蛋白的重组狂犬病病毒和来自另一种狂犬病病毒如莫科拉病毒,拉各斯蝙蝠病毒和/或西高蝙蝠病毒的至少一种异源糖蛋白。 在具体实施方案中,重组狂犬病病毒包括两种或三种异源性淋巴细胞病毒糖蛋白。 所公开的重组狂犬病病毒可用作泛菌丝炎病毒疫苗,以提供针对引起狂犬病的狂犬病病毒的保护。
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公开(公告)号:US4290051A
公开(公告)日:1981-09-15
申请号:US62175
申请日:1979-07-30
申请人: Alexei P. Stakhov , Andrei A. Kozak , Nikolai A. Solyanichenko , Ivan V. Kuzmin , Alexei D. Azarov
发明人: Alexei P. Stakhov , Andrei A. Kozak , Nikolai A. Solyanichenko , Ivan V. Kuzmin , Alexei D. Azarov
CPC分类号: H03M7/001
摘要: A device for reducing irrational-base codes to a minimal form, comprising "n" identical functional cells whereof each Bth cell incorporates a flip-flop with a count input and an AND convolution element intended to evaluate the possibility of performing the operation of convoluting the (B-1)th and (B-p-1)th code digits to the Bth code digit. One of the inputs of the AND convolution element is connected to an inverting output of the flip-flop whose direct output serves as an information output of the Bth functional cell. The flip-flop has its set, reset and count inputs connected to an information input, a convolution set input and an inversion signal input, respectively, of the Bth functional cell, the inversion signal input being connected to an information output of the (B-1)th functional cell. The remaining inputs of the AND convolution element are a first convolution signal input, a second convolution signal input and a convolution control input of the Bth functional cell. An output of the AND convolution element is a convolution signal output of the Bth functional cell, which output is respectively connected to a first convolution signal input and a second convolution signal input of the (B-1)th and (B-p-1)th functional cells.
摘要翻译: 一种用于将非理性基础代码减少到最小形式的装置,包括“n”个相同的功能单元,其中每个第B个单元包括具有计数输入的触发器和用于评估执行卷积运算的操作的可能性的AND卷积单元 (B-1)和(Bp-1)个码位数。 AND卷积单元的输入之一连接到触发器的反相输出,其直接输出用作B功能单元的信息输出。 触发器具有分别连接到B功能单元的信息输入,卷积设置输入和反相信号输入的设定,复位和计数输入,反相信号输入连接到(B -1)功能细胞。 AND卷积单元的剩余输入是第B卷函数单元的第一卷积信号输入,第二卷积信号输入和卷积控制输入。 AND卷积单元的输出是B功能单元的卷积信号输出,该输出分别连接到第(B-1)和(B-1)th的第一卷积信号输入和第二卷积信号输入 功能细胞。
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公开(公告)号:US20130095137A1
公开(公告)日:2013-04-18
申请号:US13806622
申请日:2011-06-23
申请人: Xianfu Wu , Charles E. Rupprecht , Ivan V. Kuzmin
发明人: Xianfu Wu , Charles E. Rupprecht , Ivan V. Kuzmin
IPC分类号: A61K39/205
CPC分类号: A61K39/205 , A61K39/12 , A61K2039/5256 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/20121 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143 , C12N2760/20152 , C12N2800/50
摘要: Described herein are recombinant rabies viruses encoding rabies virus glycoprotein and at least one heterologous glycoprotein from another lyssavirus, such as Mokola virus, Lagos bat virus and/or West Caucasian bat virus. In particular embodiments, the recombinant rabies virus includes two or three heterologous lyssavirus glycoproteins. The disclosed recombinant rabies viruses can be used as pan-lyssavirus vaccines to provide protection against lyssaviruses that cause rabies.
摘要翻译: 本文描述的是编码狂犬病病毒糖蛋白的重组狂犬病病毒和来自另一种狂犬病病毒如莫科拉病毒,拉各斯蝙蝠病毒和/或西高蝙蝠病毒的至少一种异源糖蛋白。 在具体实施方案中,重组狂犬病病毒包括两种或三种异源性淋巴细胞病毒糖蛋白。 所公开的重组狂犬病病毒可用作泛菌丝炎病毒疫苗,以提供针对引起狂犬病的狂犬病病毒的保护。
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