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公开(公告)号：US5561899A
公开(公告)日：1996-10-08
申请号：US500348
申请日：1995-07-10
CPC分类号： H02G1/1256 , Y10S83/947 , Y10T29/49117 , Y10T83/0333 , Y10T83/0581
摘要： Apparatus for feeding an insulated electrical wire, or the like, axially with respect to a transverse plane in which a single pair of blade cutting edges are supported for movement toward and away from the axis of the wire. Each blade has a continuous cutting edge forming the periphery of an opening through the blade. The wire is advanced a predetermined distance through the aligned blade openings by a pair of conveyors on opposite sides of the plane of the blade edges. The blades are moved in opposite directions to sever a premeasured length of wire from the supply by first portions of each blade edge. The severed wire portion is then moved by the conveyors to a second axial position and the blades are again moved to cause second portions of the cutting edges to pass partially through the layer of insulation, stopping before contacting the conductor. Axial movement of the wire then causes the engaged blades to sever a slug of insulation and strip it partially or fully from the conductor. The rollers of both conveyors which are nearest the plane of the blade edges are of smaller diameter than the distal rollers, thereby permitting the conveyors to extend and support the wire at positions closer to the blades than otherwise possible.
摘要翻译： 用于相对于横向平面轴向地供给绝缘电线等的装置，其中一对刀片切割刃被支撑以朝向和远离线的轴线移动。 每个叶片具有形成穿过叶片的开口的周边的连续切割边缘。 线通过一对输送机在叶片边缘的平面的相对侧上通过对准的叶片开口前进预定距离。 叶片沿相反方向移动，以从每个叶片边缘的第一部分切断来自供应源的预测长度的线。 切断的线部分然后被输送机移动到第二轴向位置，并且叶片再次移动以使切削刃的第二部分部分地穿过绝缘层，在接触导体之前停止。 导线的轴向运动将导致接合的叶片切断绝缘块，并将其从导体部分或完全剥离。 两个输送机的最靠近叶片边缘的平面的滚子的直径小于远端滚筒的直径，从而允许输送机在比其他可能的位置更靠近叶片的位置延伸和支撑导线。
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公开(公告)号：US08282935B2
公开(公告)日：2012-10-09
申请号：US12017421
申请日：2008-01-22
CPC分类号： C07K14/70539 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/0011 , A61K39/12 , A61K39/285 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/8509 , C12N2799/023
摘要： The invention provides novel vaccination strategies based on a prime-boost vaccination regiment. The inventors have determined improved ways of boosting an immune response in a patient previously primed or exposed to a plurality of epitopes. The improved method requires the epitopes in the boosting phase to be administered individually, i.e. held on separate peptide constructs.
摘要翻译： 本发明提供了基于初级加强疫苗接种团的新型疫苗接种策略。 本发明人已经确定了在先前引发或暴露于多个表位的患者中增强免疫应答的改进方法。 改进的方法需要在加强阶段中分别施用表位，即保持在单独的肽构建体上。
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公开(公告)号：US20110236418A1
公开(公告)日：2011-09-29
申请号：US13112379
申请日：2011-05-20
CPC分类号： C12N15/86 , A61K2039/51 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N2740/16043
摘要： The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.
摘要翻译： 本发明涉及用于改进疫苗接种策略的材料和方法，特别是涉及使用包含编码抗原的核酸的慢病毒的方法，或使用这种慢病毒转导的抗原呈递细胞，以异源初次加强免疫接种刺激针对所编码的抗原的免疫应答 政权。
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公开(公告)号：US20080260780A1
公开(公告)日：2008-10-23
申请号：US12017421
申请日：2008-01-22
CPC分类号： C07K14/70539 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/0011 , A61K39/12 , A61K39/285 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/8509 , C12N2799/023
摘要： The invention provides novel vaccination strategies based on a prime-boost vaccination regiment. The inventors have determined improved ways of boosting an immune response in a patient previously primed or exposed to a plurality of epitopes. The improved method requires the epitopes in the boosting phase to be administered individually, i.e. held on separate peptide constructs.
摘要翻译： 本发明提供了基于初级加强疫苗接种团的新型疫苗接种策略。 本发明人已经确定了在先前引发或暴露于多个表位的患者中增强免疫应答的改进方法。 改进的方法需要在加强阶段中分别施用表位，即保持在单独的肽构建体上。
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公开(公告)号：US06681656B2
公开(公告)日：2004-01-27
申请号：US10359490
申请日：2003-02-05
申请人： David J. Palmowski
发明人： David J. Palmowski
IPC分类号： H02G112
CPC分类号： H02G1/127 , H02G1/1265 , Y10S83/924 , Y10S83/947 , Y10T83/04 , Y10T83/8772 , Y10T83/8796
摘要： Apparatus for supporting a coaxial cable, or the like, and effecting cutting and stripping operations to remove a portion of one or more layers which concentrically cover a central conductor. A single blade, having a circular cutting edge, is moved in an orbital path about the cable with rotary motion of a motor translated to orbital motion of the blade through a plurality of plates relatively movable on crossed, linear, roller bearings and a shaft eccentrically affixed to the motor with the shaft and motor axes at an acute angle to one another. The shaft extends through a spherical bearing mounted in one of the plates, thereby translating nutational motion of the shaft to orbiting motion of the plate which is directly attached to the blade. A unique clamping assembly includes a pair of jaws having respective gear racks engaging a single pinion gear on a motor output shaft for linear movement of the jaws by equal distances in opposite directions. A microprocessor controls the level of current to the motor, thereby adjusting the clamping force applied to the cable, and increases this force during the stripping operation, when maximum axial force is applied to the cable. A guide bushing establishes the radial position of the cable axis and is stationary during blade movement, thereby permitting the opening in the bushing to closely approximate the cable diameter. The position of the bushing is adjustable to align the central axis of the bushing opening with that of the blade cutting edge. The bushing is also movable to an inoperative position to permit unobstructed access to the blade for replacement thereof. A pair of gripping members are movable to engage the severed portion of the covering layer to assist in the stripping operation, and a unique combination of hardware and software is provided for calibrating the position of the gripping members at equal distances from the axis of the cable.
摘要翻译： 用于支撑同轴电缆等的装置，并且进行切割和剥离操作以去除同心地覆盖中心导体的一个或多个层的一部分。 具有圆形切割边缘的单个刀片在围绕电缆的轨道路径中移动，电动机的旋转运动被转换成刀片的轨道运动，该多个板可在交叉的，线性的，滚动轴承和轴偏心地相对移动 固定在马达上，轴和马达轴线彼此成锐角。 轴延伸穿过安装在其中一个板中的球面轴承，从而将轴的纵向运动平移到直接附接到叶片的板的轨道运动。 独特的夹紧组件包括一对钳口，其具有与马达输出轴上的单个小齿轮啮合的相应的齿轮架，用于沿相反的方向使夹爪线性移动等距离。 微处理器控制电动机的电流，从而调整施加到电缆的夹紧力，并且当最大的轴向力施加到电缆时，在剥离操作期间增加该力。 引导衬套建立电缆轴线的径向位置，并且在刀片运动期间是静止的，从而允许衬套中的开口紧密接近电缆直径。 衬套的位置是可调节的，以使衬套开口的中心轴线与刀片切削刃的中心轴对齐。 衬套也可移动到非工作位置，以便不间断地进入刀片以便更换刀片。 一对抓握构件可移动以接合覆盖层的切断部分以帮助剥离操作，并且提供硬件和软件的独特组合用于校准夹持构件的距离电缆轴线等距离的位置 。
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公开(公告)号：US06588302B1
公开(公告)日：2003-07-08
申请号：US09640843
申请日：2000-08-16
申请人： David J. Palmowski
发明人： David J. Palmowski
IPC分类号： H02G112
CPC分类号： H02G1/127 , H02G1/1265 , Y10S83/924 , Y10S83/947 , Y10T83/04 , Y10T83/8772 , Y10T83/8796
摘要： Apparatus for supporting a coaxial cable, or the like, and effecting cutting and stripping operations to remove a portion of one or more layers which concentrically cover a central conductor. A single blade, having a circular cutting edge, is moved in an orbital path about the cable with rotary motion of a motor translated to orbital motion of the blade through a plurality of plates relatively movable on crossed, linear, roller bearings and a shaft eccentrically affixed to the motor with the shaft and motor axes at an acute angle to one another. The shaft extends through a spherical bearing mounted in one of the plates, thereby translating nutational motion of the shaft to orbiting motion of the plate which is directly attached to the blade. A unique clamping assembly includes a pair of jaws having respective gear racks engaging a single pinion gear on a motor output shaft for linear movement of the jaws by equal distances in opposite directions. A microprocessor controls the level of current to the motor, thereby adjusting the clamping force applied to the cable, and increases this force during the stripping operation, when maximum axial force is applied to the cable. A guide bushing establishes the radial position of the cable axis and is stationary during blade movement, thereby permitting the opening in the bushing to closely approximate the cable diameter. The position of the bushing is adjustable to align the central axis of the bushing opening with that of the blade cutting edge. The bushing is also movable to an inoperative position to permit unobstructed access to the blade for replacement thereof. A pair of gripping members are movable to engage the severed portion of the covering layer to assist in the stripping operation, and a unique combination of hardware and software is provided for calibrating the position of the gripping members at equal distances from the axis of the cable.
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公开(公告)号：US5445051A
公开(公告)日：1995-08-29
申请号：US200817
申请日：1994-02-23
IPC分类号： H02G1/12
CPC分类号： H02G1/1256 , Y10S83/947 , Y10T29/49117 , Y10T83/0333 , Y10T83/0581
摘要： Apparatus for feeding an insulated electrical wire, or the like, axially with respect to a transverse plane in which a single pair of blade cutting edges are supported for movement toward and away from the axis of the wire. Each blade has a continuous cutting edge forming the periphery of an opening through the blade. The wire is advanced a predetermined distance through the aligned blade openings by a pair of conveyors on opposite sides of the plane of the blade edges. The blades are moved in opposite directions to sever a premeasured length of wire from the supply by first portions of each blade edge. The severed wire portion is then moved by the conveyors to a second axial position and the blades are again moved to cause second portions of the cutting edges to pass partially through the layer of insulation, stopping before contacting the conductor. Axial movement of the wire then causes the engaged blades to sever a slug of insulation and strip it partially or fully from the conductor. The rollers of both conveyors which are nearest the plane of the blade edges are of smaller diameter than the distal rollers, thereby permitting the conveyors to extend and support the wire at positions closer to the blades than otherwise possible.
摘要翻译： 用于相对于横向平面轴向地供给绝缘电线等的装置，其中一对刀片切割刃被支撑以朝向和远离线的轴线移动。 每个叶片具有形成穿过叶片的开口的周边的连续切割边缘。 线通过一对输送机在叶片边缘的平面的相对侧上通过对准的叶片开口前进预定距离。 叶片沿相反方向移动，以从每个叶片边缘的第一部分切断来自供应源的预测长度的线。 切断的线部分然后被输送机移动到第二轴向位置，并且叶片再次移动以使切削刃的第二部分部分地穿过绝缘层，在接触导体之前停止。 导线的轴向运动将导致接合的叶片切断绝缘块，并将其从导体部分或完全剥离。 两个输送机的最靠近叶片边缘的平面的滚子的直径小于远端滚筒的直径，从而允许输送机在比其他可能的位置更靠近叶片的位置延伸并支撑导线。
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公开(公告)号：US07178434B2
公开(公告)日：2007-02-20
申请号：US10920774
申请日：2004-08-18
申请人： David J. Palmowski
发明人： David J. Palmowski
IPC分类号： B26D1/00
CPC分类号： H02G1/127 , H02G1/1265 , Y10S83/924 , Y10S83/947 , Y10T83/04 , Y10T83/8772 , Y10T83/8796
摘要： Apparatus for supporting a coaxial cable, or the like, and effecting cutting and stripping operations to remove a portion of one or more layers which concentrically cover a central conductor. A single blade, having a circular cutting edge, is moved in an orbital path about the cable with rotary motion of a motor translated to orbital motion of the blade through a plurality of plates relatively movable on crossed, linear, roller bearings and a shaft eccentrically affixed to the motor with the shaft and motor axes at an acute angle to one another. The shaft extends through a spherical bearing mounted in one of the plates, thereby translating nutational motion of the shaft to orbiting motion of the plate which is directly attached to the blade. A unique clamping assembly includes a pair of jaws having respective gear racks engaging a single pinion gear on a motor output shaft for linear movement of the jaws by equal distances in opposite directions. A microprocessor controls the level of current to the motor, thereby adjusting the clamping force applied to the cable, and increases this force during the stripping operation, when maximum axial force is applied to the cable. A guide bushing establishes the radial position of the cable axis and is stationary during blade movement, thereby permitting the opening in the bushing to closely approximate the cable diameter. The position of the bushing is adjustable to align the central axis of the bushing opening with that of the blade cutting edge. The bushing is also movable to an inoperative position to permit unobstructed access to the blade for replacement thereof. A pair of gripping members are movable to engage the severed portion of the covering layer to assist in the stripping operation, and a unique combination of hardware and software is provided for calibrating the position of the gripping members at equal distances from the axis of the cable.
摘要翻译： 用于支撑同轴电缆等的装置，并且进行切割和剥离操作以去除同心地覆盖中心导体的一个或多个层的一部分。 具有圆形切割边缘的单个刀片在围绕电缆的轨道路径中移动，电动机的旋转运动被转换成刀片的轨道运动，该多个板可在交叉的，线性的，滚动轴承和轴偏心地相对移动 固定在马达上，轴和马达轴线彼此成锐角。 轴延伸穿过安装在其中一个板中的球面轴承，从而将轴的纵向运动平移到直接附接到叶片的板的轨道运动。 独特的夹紧组件包括一对钳口，其具有与马达输出轴上的单个小齿轮啮合的相应的齿轮架，用于沿相反的方向使夹爪线性移动等距离。 微处理器控制电动机的电流，从而调整施加到电缆的夹紧力，并且当最大的轴向力施加到电缆时，在剥离操作期间增加该力。 引导衬套建立电缆轴线的径向位置，并且在刀片运动期间是静止的，从而允许衬套中的开口紧密接近电缆直径。 衬套的位置是可调节的，以使衬套开口的中心轴线与刀片切削刃的中心轴对齐。 衬套也可移动到非工作位置，以便不间断地进入刀片以便更换。 一对抓握构件可移动以接合覆盖层的切断部分以帮助剥离操作，并且提供硬件和软件的独特组合用于校准夹持构件的距离电缆轴线等距离的位置 。
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公开(公告)号：US07152513B2
公开(公告)日：2006-12-26
申请号：US11160244
申请日：2005-06-15
申请人： David J. Palmowski
发明人： David J. Palmowski
IPC分类号： B26D3/08
CPC分类号： H02G1/127 , H02G1/1265 , Y10S83/924 , Y10S83/947 , Y10T83/04 , Y10T83/8772 , Y10T83/8796
摘要： Apparatus for supporting a coaxial cable, or the like, and effecting cutting and stripping operations to remove a portion of one or more layers which concentrically cover a central conductor. A single blade, having a circular cutting edge, is moved in an orbital path about the cable with rotary motion of a motor translated to orbital motion of the blade through a plurality of plates relatively movable on crossed, linear, roller bearings and a shaft eccentrically affixed to the motor with the shaft and motor axes at an acute angle to one another. The shaft extends through a spherical bearing mounted in one of the plates, thereby translating nutational motion of the shaft to orbiting motion of the plate which is directly attached to the blade. A unique clamping assembly includes a pair of jaws having respective gear racks engaging a single pinion gear on a motor output shaft for linear movement of the jaws by equal distances in opposite directions. A microprocessor controls the level of current to the motor, thereby adjusting the clamping force applied to the cable, and increases this force during the stripping operation, when maximum axial force is applied to the cable. A guide bushing establishes the radial position of the cable axis and is stationary during blade movement, thereby permitting the opening in the bushing to closely approximate the cable diameter. The position of the bushing is adjustable to align the central axis of the bushing opening with that of the blade cutting edge. The bushing is also movable to an inoperative position to permit unobstructed access to the blade for replacement thereof. A pair of gripping members are movable to engage the severed portion of the covering layer to assist in the stripping operation, and a unique combination of hardware and software is provided for calibrating the position of the gripping members at equal distances from the axis of the cable.
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公开(公告)号：US20060257416A1
公开(公告)日：2006-11-16
申请号：US10560389
申请日：2004-06-14
申请人： J Palmowski , Lucien Lopes , Yasuhiro Ikeda , Vincenzo Cerundolo , Mary Collins
发明人： J Palmowski , Lucien Lopes , Yasuhiro Ikeda , Vincenzo Cerundolo , Mary Collins
CPC分类号： C12N15/86 , A61K2039/51 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N2740/16043
摘要： The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.
摘要翻译： 本发明涉及用于改进疫苗接种策略的材料和方法，特别是涉及使用包含编码抗原的核酸的慢病毒的方法，或使用这种慢病毒转导的抗原呈递细胞，以异源初次加强免疫接种刺激针对所编码的抗原的免疫应答 政权。
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