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1.发明申请公开(公告)号：US20180030047A1
公开(公告)日：2018-02-01
申请号：US15507028
申请日：2015-08-26
发明人： Olivier MARTIN , Estelle GALLIENNE-BOIVINEAU , Cyril NICOLAS , Piotr B. HECZKO , Grazyna STOCHEL , Magdalena STRUS , Agnieszka KYZIOL , Diana MIKOLAJCZYK , Agnieszka MACHUL
IPC分类号： C07D471/04 , A61K31/40 , A01N43/36 , C07D211/40 , A61K31/551 , A01N43/40 , A61K31/437 , A01N43/90 , C07D487/04 , C07D207/12 , A61K31/445
摘要： Disclosed are compounds of the following formula I: wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple bond or a radical —CHR1— wherein R1 represents: a hydrogen atom, or a linear or branched, possibly interrupted by up to 3 heteroatoms selected from O, S or N and/or possibly substituted, (C1-C12)-alkyl, R2, R3 and R4 represent independently from each other: a hydrogen atom, or a linear or branched (C1-C12)-alkyl or (C1-C12)-acyl R5 represents: a hydrogen atom, or a linear or branched, possibly substituted, (C1-C13)-alkyl possibly interrupted by up to 3 heteroatoms selected from O, S or N, R6 represents: a hydrogen atom, or a linear or branched possibly substituted (C1-C12)-alkyl, possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, for their use as antibacterial drugs.
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公开(公告)号：US10745395B2
公开(公告)日：2020-08-18
申请号：US15507028
申请日：2015-08-26
发明人： Olivier Martin , Estelle Gallienne-Boivineau , Cyril Nicolas , Piotr B. Heczko , Grazyna Stochel , Magdalena Strus , Agnieszka Kyziol , Diana Mikolajczyk , Agnieszka Machul
IPC分类号： C07D207/12 , C07D471/04 , C07D211/46 , A01N43/36 , A01N43/40 , A01N43/90 , A61K31/40 , A61K31/437 , A61K31/445 , A61K31/551 , C07D211/40 , C07D487/04
摘要： The present invention relates to compounds of the following formula (I), wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple bond or a radical —CHR1 wherein R1 represents:—a hydrogen atom, or—a linear or branched, possibly interrupted by up to 3 heteroatoms selected from O, S or N and/or possibly substituted, (C1-C12)-alkyl, R2, R3 and R4 represent independently from each other:—a hydrogen atom, or—a linear or branched (C1-C12-alkyl or (C1-C12)-acyl R5 represents:—a hydrogen atom, or—a linear or branched, possibly substituted, (C1-C13)-alkyi possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, R6 represents:—a hydrogen atom, or—a linear or branched possibly substituted (C1-C12)-alkyl, possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, for their use as antibacterial drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria.
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公开(公告)号：US20240051991A1
公开(公告)日：2024-02-15
申请号：US18555877
申请日：2022-03-16
摘要： Disclosed herein are recombinant miropin polypeptides capable of inhibiting a broad spectrum of proteases, including Kgp and Rgp gingipains, trypsin, plasmin, elastase, cathepsin G, cathepsin L, and plasma kallikrein. Also disclosed herein are methods of treating a disease or condition in a subject that involves administering to the subject a recombinant miropin disclosed herein.
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公开(公告)号：US09954240B2
公开(公告)日：2018-04-24
申请号：US15132011
申请日：2016-04-18
发明人： Dirk Henkensmeier , Jong Hyun Jang , Hyoung-Juhn Kim , Jin Young Kim , Sung Pil Yoon , Jonghee Han , Suk Woo Nam , Ngoc My Hanh Duong , Artur Michalak , Karol Dyduch , Mateusz Brela
IPC分类号： H01M8/103 , H01M8/1004 , H01M8/12 , H01M8/1027 , C08G65/40 , C08G65/48 , C08G65/00 , H01M8/1018
CPC分类号： C08G65/40 , C08G65/007 , C08G65/4037 , C08G65/48 , H01M8/1004 , H01M8/1025 , H01M8/1027 , H01M8/103 , H01M8/12 , H01M2008/1095 , Y02P70/56
摘要： Disclosed are a 5-(2,6-dioxyphenyl)tetrazole-containing polymer, a method for preparing the same, a membrane containing the same and an electrochemical device, particularly a high temperature polymer electrolyte membrane fuel cell, including the membrane. The membrane containing the 5-(2,6-dioxyphenyl)tetrazole-containing polymer is capable of providing high proton conductivity and exhibiting good mechanical properties, thereby capable of providing superior fuel cell performance. Accordingly, the membrane may be usefully used in an electrochemical device, particularly a fuel cell, more particularly a high temperature polymer electrolyte membrane fuel cell.
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5.发明申请5-(5-(2,6-DIOXYPHENYL)TETRAZOLE CONTAINING POLYMER, MEMBRANE CONTAINING THE SAME, ELECTROCHEMICAL DEVICE INCLUDING THE MEMBRANE AND METHOD FOR PREPARING THE SAME 有权含有聚合物的5-（5-（2,6-二氧基苯基）四唑基聚合物，含有该膜的膜，包括该膜的电化学装置及其制备方法公开(公告)号：US20160308229A1
公开(公告)日：2016-10-20
申请号：US15132011
申请日：2016-04-18
发明人： Dirk Henkensmeier , Jong Hyun JANG , Hyoung-Juhn KIM , Jin Young KIM , Sung Pil YOON , Jonghee HAN , Suk Woo NAM , Ngoc My Hanh Duong , Artur Michalak , Karol Dyduch , Mateusz Brela
IPC分类号： H01M8/103 , H01M8/1004 , H01M8/1027 , C08G65/40 , H01M8/12
CPC分类号： C08G65/40 , C08G65/007 , C08G65/4037 , C08G65/48 , H01M8/1004 , H01M8/1025 , H01M8/1027 , H01M8/103 , H01M8/12 , H01M2008/1095 , Y02P70/56
摘要： Disclosed are a 5-(2,6-dioxyphenyl)tetrazole-containing polymer, a method for preparing the same, a membrane containing the same and an electrochemical device, particularly a high temperature polymer electrolyte membrane fuel cell, including the membrane. The membrane containing the 5-(2,6-dioxyphenyl)tetrazole-containing polymer is capable of providing high proton conductivity and exhibiting good mechanical properties, thereby capable of providing superior fuel cell performance. Accordingly, the membrane may be usefully used in an electrochemical device, particularly a fuel cell, more particularly a high temperature polymer electrolyte membrane fuel cell.
摘要翻译： 公开了含有5-（2,6-二氧代苯基）四唑的聚合物，其制备方法，含有该聚合物的膜和包含该膜的电化学装置，特别是高温高分子电解质膜燃料电池。 含有5-（2,6-二氧代苯基）四唑的聚合物的膜能够提供高质子传导性并表现出良好的机械性能，从而能够提供优异的燃料电池性能。 因此，膜可以有用地用于电化学装置，特别是燃料电池，特别是高温聚合物电解质膜燃料电池中。
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