公开(公告)号：US11458229B2

公开(公告)日：2022-10-04

申请号：US15764243

申请日：2016-09-28

Applicant: Jichi Medical University ,  Otsuka Pharmaceutical Factory, Inc.

Inventor： Tomonori Yano ,  Atsushi Ohhata ,  Toshihiro Goto ,  Yuji Hiraki

IPC: A61L31/04 ,  A61L31/14 ,  A61B1/015 ,  A61L31/02

Abstract: The purpose of the present invention is to provide a viscoelastic composition having excellent operability, which is suitable for use in securing the field of view of an endoscope when opaque dark-colored liquid accumulates inside a canal and obstructs the field of view of the endoscope, the viscoelastic composition securing the field of view by pushing the liquid aside, and to provide a method for securing the field of view of an endoscope using the viscoelastic composition. The viscoelastic composition for securing the field of view of an endoscope comprises a substance having viscoelastic properties and water, preferably has a hardness of 550 N/m2 or less, a viscosity (25° C.) of 200 to 2,000 mPa·s, and a loss tangent of 0.6 or less, and more preferably has an electrical conductivity of 250 μS/cm or less. The method for securing the field of view of an endoscope comprises feeding the viscoelastic composition from a proximal part of the endoscope, through a channel, into a distal part of the endoscope.

公开(公告)号：US20220296246A1

公开(公告)日：2022-09-22

申请号：US17730705

申请日：2022-04-27

Applicant: JICHI MEDICAL UNIVERSITY

Inventor： Yuji Kaneda

IPC: A61B17/12

Abstract: This tool is for treating an excised end of a body organ and is provided with: a long and thin, flexible first band section having a distal end and a proximal end that are made of a biodegradable-absorptive polymer; a long and thin, flexible second band section having a distal end and a proximal end that are made of a biodegradable-absorptive polymer; and a first locking section having a first ratchet claw made of a biodegradable-absorptive polymer, wherein the first locking section is formed at the distal end of the second band section, the distal end of the first band section and the proximal end of the second band section are joined together, at least one ratchet tooth that is capable of meshing with the first ratchet claw is formed on the external surface of the first band section, and the engagement of the ratchet tooth with the first ratchet claw forms a flattened ring which is used to bind a body organ so as to ligate a tube or cavity that opens at an excised end of the body organ.

公开(公告)号：US11441125B2

公开(公告)日：2022-09-13

申请号：US15516107

申请日：2015-10-02

Applicant: JICHI MEDICAL UNIVERSITY

Inventor： Hitoshi Endo ,  Yasumitsu Nagao ,  Yutaka Hanazono ,  Kaoru Tominaga ,  Tsukasa Ohmori

IPC: C12N5/073 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/02 ,  A01K67/027 ,  G01N33/50 ,  C12Q1/02 ,  C12N15/09 ,  C12Q1/68 ,  C12N5/00

Abstract: The present application relates to a method for reestablishing stem cells capable of forming chimeras, and cells obtained by the method. The method of the present invention is a technique for monocloning stem cells, for example, capable of forming chimeras from a heterogeneous cell population to obtain high-quality stem cells.

公开(公告)号：US20220275399A1

公开(公告)日：2022-09-01

申请号：US17732901

申请日：2022-04-29

Applicant: Jichi Medical University ,  Gene Therapy Research Institution Co., Ltd.

Inventor： Shin-ichi Muramatsu ,  Keiji Oguro ,  Kuniko Shimazaki

IPC: C12N15/864 ,  A61P25/08 ,  A61P25/28 ,  A61K38/17 ,  C07K14/705 ,  A61K35/761 ,  A61K45/06 ,  A61K48/00

Abstract: Provided is a novel gene therapy means for neurological diseases including epilepsy. The present invention provides: a recombinant adeno-associated virus vector for use in the treatment of neurological diseases including epilepsy, which comprises a polynucleotide encoding a protein capable of improving the excitation-inhibiting function of an inhibitory synapse in vivo, preferably neuroligin-2 protein; a pharmaceutical composition comprising said recombinant vector; and others. The present invention also provides a method for treating a disease such as epilepsy using the recombinant vector.

公开(公告)号：US20220071495A1

公开(公告)日：2022-03-10

申请号：US17484790

申请日：2021-09-24

Applicant: OMRON HEALTHCARE Co., Ltd. ,  JICHI MEDICAL UNIVERSITY

Inventor： Ayako KOKUBO ,  Mitsuo KUWABARA ,  Shingo YAMASHITA ,  Kazuomi KARIO

IPC: A61B5/022 ,  A61B5/00

Abstract: A blood pressure-related information display device, for visualizing and displaying information relating to blood pressure surges, is provided with: a blood pressure surge detection unit which, from time series data of blood pressure which changes linked to the subject's pulse, detects a blood pressure surge on the basis of a preset determination standard; a bodily state input unit which, together with the time series data of blood pressure, inputs bodily state information which indicates the bodily state of the subject; an extraction unit which extracts a feature value of the blood pressure surge; a statistical processing unit which performs statistical processing of the extracted feature value of the blood pressure surge; a calculation unit which calculates a feature value of the subject's bodily state; a display processing unit which performs processing for displaying, on a display screen, the correlation between the feature value of the blood pressure surge which was subjected to statistical processing, and the feature value of the bodily state.

公开(公告)号：US20220008023A1

公开(公告)日：2022-01-13

申请号：US17482297

申请日：2021-09-22

Applicant: OMRON HEALTHCARE CO., LTD. ,  JICHI MEDICAL UNIVERSITY

Inventor： Ayako KOKUBO ,  Mitsuo KUWABARA ,  Shingo YAMASHITA ,  Kazuomi KARIO

IPC: A61B5/00 ,  G06T11/20 ,  G06T11/00 ,  A61B5/021

Abstract: According to the present invention, blood pressure surges is detected from time-series data on blood pressure of a subject that varies with pulsation based on predetermined determination criteria. A feature amount indicating a characteristic of each blood pressure surge thus detected is obtained. Statistical processing is performed on an occurrence number of the blood pressure surges thus detected and/or the feature amount to obtain a statistical amount for each of time slots. A required attention degree indicating a level of attention being required to the blood pressure surge is obtained for each of the time slots based on the statistical amount of the occurrence number of the blood pressure surges and/or the feature amount. The required attention degree thus obtained and/or the statistical amount are displayed side by side for each of the time slots on a display screen.

公开(公告)号：US10945598B2

公开(公告)日：2021-03-16

申请号：US16269221

申请日：2019-02-06

Applicant: JICHI MEDICAL UNIVERSITY ,  Takahiko Hayashi

Inventor： Siamak Yousefi ,  Hidenori Takahashi ,  Takahiko Hayashi

IPC: G06K9/00 ,  A61B3/107 ,  A61B3/10 ,  G16H50/70 ,  A61B3/00

Abstract: A method for assisting corneal severity identification, the method comprising obtaining a corneal configuration data set of a cornea to be examined by a tomography such as an optical coherence tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map.

公开(公告)号：US20180280587A1

公开(公告)日：2018-10-04

申请号：US15764243

申请日：2016-09-28

Applicant: Jichi Medical University ,  Otsuka Pharmaceutical Factory, Inc.

Inventor： Tomonori Yano ,  Atsushi Ohhata ,  Toshihiro Goto ,  Yuji Hiraki

IPC: A61L31/04 ,  A61L31/02 ,  A61L31/14 ,  A61B1/015

Abstract: The purpose of the present invention is to provide a viscoelastic composition having excellent operability, which is suitable for use in securing the field of view of an endoscope when opaque dark-colored liquid accumulates inside a canal and obstructs the field of view of the endoscope, the viscoelastic composition securing the field of view by pushing the liquid aside, and to provide a method for securing the field of view of an endoscope using the viscoelastic composition. The viscoelastic composition for securing the field of view of an endoscope comprises a substance having viscoelastic properties and water, preferably has a hardness of 550 N/m2 or less, a viscosity (25° C.) of 200 to 2,000 mPa·s, and a loss tangent of 0.6 or less, and more preferably has an electrical conductivity of 250 μS/cm or less. The method for securing the field of view of an endoscope comprises feeding the viscoelastic composition from a proximal part of the endoscope, through a channel, into a distal part of the endoscope.

公开(公告)号：US20150104434A1

公开(公告)日：2015-04-16

申请号：US14565104

申请日：2014-12-09

Applicant: Otsuka Pharmaceutical Factory, Inc. ,  Jichi Medical University ,  The Jikei University ,  Tokyo Women's Medical University

Inventor： Eiji KOBAYASHI ,  Takashi YOKOO ,  Koutaro KAI

IPC: C12N5/071 ,  A61K35/22

CPC classification number: C12N5/0697 ,  A61K35/12 ,  A61K35/22 ,  C12N5/0686 ,  C12N2502/02 ,  C12N2506/1346 ,  C12N2523/00

Abstract: The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof.

Abstract translation: 本发明提供一种人体肾前体，其含有从生物体分离出的非人哺乳动物肾脏，其中，所述肾脏已经在生物体外进行了冻融解冻处理，并含有转移到生物体外的哺乳动物间充质干细胞， 及其制造方法。

公开(公告)号：US20240327420A1

公开(公告)日：2024-10-03

申请号：US18710113

申请日：2022-11-14

Applicant: JICHI MEDICAL UNIVERSITY

Inventor： Hitoshi OSAKA ,  Akihiko MIYAUCHI ,  Eriko JIMBO ,  Mizuki KOBAYASHI

IPC: C07D491/06 ,  A61K31/473 ,  A61K31/4741 ,  C07D221/18

CPC classification number: C07D491/06 ,  A61K31/473 ,  A61K31/4741 ,  C07D221/18

Abstract: The present invention provides a means whereby it is possible to clarify the mechanism of manifestation of symptoms, an illness, or dysfunction caused by mitochondrial dysfunction and prevent or treat symptoms, an illness, or dysfunction relating to the same mechanism of manifestation. One embodiment of the present invention relates to a ferroptosis inhibitor containing a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient. Another embodiment of the present invention relates to a medicine that contains the ferroptosis inhibitor as an active ingredient and is for use in the prevention or treatment of symptoms, an illness, or dysfunction relating to ferroptosis. Yet another embodiment of the present invention relates to a compound represented by formula (I-1), a salt thereof, or a solvate thereof.