公开(公告)号：US20180200376A1

公开(公告)日：2018-07-19

申请号：US15743486

申请日：2016-07-08

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Margherita MORPURGO

IPC: A61K47/62 ,  A61K47/60 ,  A61K47/54 ,  A61K31/573 ,  A61K31/704

CPC classification number: A61K47/62 ,  A61K31/573 ,  A61K31/704 ,  A61K47/545 ,  A61K47/549 ,  A61K47/551 ,  A61K47/60 ,  A61K47/65

Abstract: Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds functionalized to make them suitable for delivering and releasing drugs are described. These nanoassembled complexes consist of central poly-avidin nucleus, i.e. nucleus formed from the self-assembling of tetrameric avidin units on oligonucleotide sequences of nucleic acids, on which biotinylated compounds are further auto-assembled through high-affinity interactions between the avidin of the central nucleus and the biotin of the biotinylated compounds. The biotinylated compounds are functionalized so as to bind drugs with a reversible bond, allowing the delivery thereof and a controlled release.

公开(公告)号：US20240254323A1

公开(公告)日：2024-08-01

申请号：US18560254

申请日：2022-05-10

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Lanfranco Callegaro ,  Giulio Bianchini

IPC: C08L5/08 ,  A61L27/20 ,  A61L27/54 ,  C08B37/08 ,  C12N5/00

CPC classification number: C08L5/08 ,  A61L27/20 ,  A61L27/54 ,  C08B37/003 ,  C08B37/0072 ,  C12N5/0068 ,  C08L2203/02 ,  C08L2312/00

Abstract: The present invention concerns a polymeric composition with improved rheological properties, comprising at least one polyanionic polysaccharide, or a derivative thereof, and a polyaminosaccharide chosen from chitosan, functionalised chitosan and salts thereof. The invention furthermore concerns methods for the preparation of said polymeric composition and uses thereof.

公开(公告)号：US11155647B2

公开(公告)日：2021-10-26

申请号：US16616731

申请日：2018-05-29

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Giulio Bianchini ,  Lanfranco Callegaro

IPC: C08B37/08 ,  A61K31/722 ,  A61K31/734 ,  A61K31/737 ,  A61K31/765 ,  A61K33/42 ,  A61K38/39

Abstract: A neutral salt consisting of a polyaminosaccharide cation and an anion, as well as a procedure for the preparation of the neutral salt and uses thereof as a biomaterial and as an ingredient in pharmaceutical compositions are disclosed. Indeed, said neutral salt has surprisingly exhibited high water-solubility and high purity, the preparation procedure having minimised the content of high-risk contaminants in the final product and reduced reaction and purification times.

公开(公告)号：US11203649B2

公开(公告)日：2021-12-21

申请号：US16757864

申请日：2018-10-24

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Giulio Bianchini ,  Lanfranco Callegaro

IPC: C08B37/08 ,  A61K31/728 ,  A61P37/06 ,  A61K45/06

Abstract: The present invention discloses a functionalized hyaluronic acid or a derivative thereof, as well as a process for the preparation thereof, and the use thereof as a biomaterial and as an ingredient in pharmaceutical compositions. The present invention furthermore discloses the use of said functionalized hyaluronic acid or a derivative thereof in the treatment of pathologies ascribable to altered galectin expression.

公开(公告)号：US11116787B2

公开(公告)日：2021-09-14

申请号：US16306983

申请日：2017-06-06

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Lanfranco Callegaro ,  Paola Brun ,  Giulio Bianchini

IPC: A61K31/728 ,  A61P41/00 ,  A61K31/702 ,  A61K31/722

Abstract: The present application describes polysaccharide compositions that can be used as modulators of cell proliferation processes and their use in tissue repair with fibrotic process inhibition. These modulation properties can be usefully used in tissue repair for the prevention of fibrotic processes and/or tissue adhesions in traumatic, post-surgical and chronic fibrotic processes associated to autoimmune diseases.

公开(公告)号：US20190160183A1

公开(公告)日：2019-05-30

申请号：US16318227

申请日：2017-07-18

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Margherita Morpurgo ,  Giulio Bianchini ,  Lanfranco Callegaro

IPC: A61K47/69 ,  A61K47/26 ,  A61K47/36 ,  A61K31/58 ,  A61K31/196 ,  A61K31/5415 ,  A61K31/407 ,  A61P19/02

Abstract: The present application describes compositions that can be used for the controlled release of pharmacological active ingredients from a viscoelastic aqueous polysaccharide matrix, and their potential use in the treatment of different stages of musculoskeletal diseases. The combination of drug release modulation and the viscoelastic nature of the composition makes possible the use thereof in the treatment of acute and chronic phases of musculoskeletal diseases characterized by an inflammatory state, and where a therapeutic effect and a viscosupplemental contribution are required.

公开(公告)号：US20210189017A1

公开(公告)日：2021-06-24

申请号：US16757864

申请日：2018-10-24

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Giulio Bianchini ,  Lanfranco Callegaro

IPC: C08B37/08 ,  A61K45/06 ,  A61K31/728 ,  A61P37/06

Abstract: The present invention discloses a functionalized hyaluronic acid or a derivative thereof, as well as a process for the preparation thereof, and the use thereof as a biomaterial and as an ingredient in pharmaceutical compositions. The present invention furthermore discloses the use of said functionalized hyaluronic acid or a derivative thereof in the treatment of pathologies ascribable to altered galectin expression.

公开(公告)号：US10525161B2

公开(公告)日：2020-01-07

申请号：US15747895

申请日：2016-07-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  JOINTHERAPEUTICS S.R.L.

Inventor： Luigi Ambrosio ,  Maria Grazia Raucci ,  Angela Longo ,  Gianfranco Carotenuto ,  Daniela Giugliano

IPC: A61L27/08 ,  A61L27/12

Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.

公开(公告)号：US20180214599A1

公开(公告)日：2018-08-02

申请号：US15747895

申请日：2016-07-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  JOINTHERAPEUTICS S.R.L.

Inventor： Luigi Ambrosio ,  Maria Grazia Raucci ,  Angela Longo ,  Gianfranco Carotenuto ,  Daniela Giugliano

IPC: A61L27/08 ,  A61L27/12

Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.

公开(公告)号：US20220213233A1

公开(公告)日：2022-07-07

申请号：US17604772

申请日：2020-04-17

Applicant: JOINTHERAPEUTICS S.R.L.

Inventor： Giulio Bianchini ,  Lanfranco Callegaro

IPC: C08B37/08 ,  A61K45/06

Abstract: A crosslinked polymer of functionalized hyaluronic acid, or derivative thereof, is disclosed, as well as a process for its preparation and its use as a biomaterial and as an ingredient in pharmaceutical compositions. The use of this crosslinked polymer in the treatment of disorders ascribable to altered galectin expression, is also disclosed.