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1.发明申请Expression Vectors Comprising the HS1 Promoter of the VAV1 Oncogene and Use Thereof for the Preparation of Pharmaceutical Compositions Intended for Somatic Gene Therapy 审中-公开包含VAV1致癌基因的HS1启动子的表达载体及其用于制备用于体细胞基因治疗的药物组合物公开(公告)号：US20090169514A1
公开(公告)日：2009-07-02
申请号：US12227879
申请日：2007-05-31
申请人： Elena Almarza Novoa , Guillermo Guenechea Amurrio , Jose Carlos Segovia Sanz , Juan Antonio Bueren Roncero , Montserrat Aldea Garcia
发明人： Elena Almarza Novoa , Guillermo Guenechea Amurrio , Jose Carlos Segovia Sanz , Juan Antonio Bueren Roncero , Montserrat Aldea Garcia
IPC分类号： A61K35/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61K31/711
CPC分类号： C12N15/86 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0393 , A61K48/00 , C12N2740/15043 , C12N2830/008
摘要： The present invention relates to the use of the HS1 promoter of the vav oncogene in the production of vectors selected from the groups of integrative vectors and non-integrative, non-plasmid vectors, for use in the preparation of pharmaceutical compositions intended for somatic gene therapy. By generating vectors that contain the HS1 promoter of the vav oncogene, it was possible to generate vectors in which the marker transgene or therapeutic transgene is expressed at moderate, but stable, levels in various cell lines both in vitro and in vivo.
摘要翻译： 本发明涉及vav致癌基因的HS1启动子在制备选自组合载体和非整合非质粒载体的载体中的用途，用于制备用于体细胞基因治疗的药物组合物 。 通过产生含有vav致癌基因的HS1启动子的载体，可以产生其中标记转基因或治疗性转基因在体外和体内的各种细胞系中以中等但稳定的水平表达的载体。
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2.发明申请Generation of Genetically Corrected Disease-free Induced Pluripotent Stem Cells 审中-公开遗传修复无病诱导多能干细胞的生成公开(公告)号：US20100303775A1
公开(公告)日：2010-12-02
申请号：US12789375
申请日：2010-05-27
CPC分类号： A61K48/005 , C12N5/0696 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2510/00 , C12N2799/027 , C12N2830/60
摘要： Methods and compositions for the generation and use of genetically corrected induced pluripotent stem cells are provided.
摘要翻译： 提供了用于产生和使用遗传修饰的诱导多能干细胞的方法和组合物。
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