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8 条记录 (耗时 0.016 秒)

    Method for diagnosing and treatment of breast cancer and pharmaceuticals composition and kit for same
    3.
    发明申请
    Method for diagnosing and treatment of breast cancer and pharmaceuticals composition and kit for same 审中-公开
    乳腺癌诊断和治疗方法以及药物组合物及其制备方法

    公开(公告)号：US20090081220A1

    公开(公告)日：2009-03-26

    申请号：US10587835

    申请日：2005-01-27

    申请人： Jacob Hochman

    发明人： Jacob Hochman

    IPC分类号： A61K39/395 ,  G01N33/53 ,  A61K39/44 ,  A61K39/00

    CPC分类号： C07K16/18 ,  A61K39/0011 ,  A61K47/6851 ,  A61K2039/575 ,  C07K2317/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N2333/15

    摘要： Among other findings, the invention is based on the identification that p14 peptide is expressed in mammary carcinoma cells harboring MMTV. Thus, the invention provides methods for diagnosing breast cancer in subjects comprising determining the levels of expression of the peptide or the levels of anti-p14 antibodies produced in the subject to the peptide. The invention also provides screening methods of individuals with high probability of having breast cancer as well as to therapeutic methods; pharmaceutical compositions and vaccine making use of the anti-p14 antibodies or p14 peptides or produced thereby.

    摘要翻译： 在其他发现中，本发明是基于p14肽在携带MMTV的乳腺癌细胞中表达的鉴定。 因此，本发明提供了用于诊断受试者中乳腺癌的方法，所述方法包括确定所述肽在所述受试者中产生的肽的表达水平或抗p14抗体的水平。 本发明还提供具有高乳腺癌概率以及治疗方法的个体的筛选方法; 药物组合物和使用抗p14抗体或p14肽的疫苗制备。

    Method for screening modulators of the immune system
    6.
    发明申请
    Method for screening modulators of the immune system 审中-公开
    筛选免疫系统调节剂的方法

    公开(公告)号：US20050169840A1

    公开(公告)日：2005-08-04

    申请号：US10519090

    申请日：2003-06-25

    申请人： Jacob Hochman

    发明人： Jacob Hochman

    IPC分类号： A01K67/027 ,  A61K49/00 ,  G01N33/50

    CPC分类号： G01N33/5088

    摘要： A method for determining whether a factor is a modulator of the transmission, of immunity from a female mammal to newborn mammals by consumption of milk from the female. A female mammal, such as a BALB/C female mouse, is exposed to the factor, and then immunized to one or more antigens. The female is then made to lactate, and newborn mammals are allowed to consume milk obtained from the lactating female. The newborns are then inoculated with the one or more antigens. The level of immunity in the newborns to the one or more antigens is then compared to that in control newborns that received milk from a female that was immunized against the one or more antigens but not exposed to the factor. A difference between the level of immunity to the one or more antigens in the experimental newborns and the control newborns is indicative that the factor is a modulator of the transmission of immunity to the one or more antigens from a female mammal to newborn mammals by consumption of milk from the female.

    摘要翻译： 用于通过从女性中消费牛奶来确定因子是否是传播调节剂，从哺乳动物到哺乳动物的免疫力的方法。 将雌性哺乳动物如BALB / C雌性小鼠暴露于该因子，然后免疫一种或多种抗原。 然后将雌性制成乳酸，并允许新生儿哺乳动物摄取从哺乳期雌性获得的牛奶。 然后用一种或多种抗原接种新生儿。 然后将新生儿对一种或多种抗原的免疫水平与接受来自针对一种或多种抗原免疫但不暴露于该因子的雌性的乳的对照新生儿中的免疫水平进行比较。 在实验新生儿和对照新生儿中的一种或多种抗原的免疫水平之间的差异表明该因子是通过消费的方式将一种或多种抗原从雌性哺乳动物免疫传递给新哺乳动物的调节剂 牛奶从女性。

    Animal model for a non-hodgkin's lymphoma
    7.
    发明授权
    Animal model for a non-hodgkin's lymphoma 失效
    非霍奇金淋巴瘤的动物模型

    公开(公告)号：US5849990A

    公开(公告)日：1998-12-15

    申请号：US358911

    申请日：1994-12-19

    申请人： Jacob Hochman

    发明人： Jacob Hochman

    IPC分类号： A01K67/027 ,  A61K49/00 ,  C12N5/00

    CPC分类号： A61K49/0008 ,  A01K67/0271

    摘要： A non-human animal model for CNS and eye-infiltrating lymphomas is produced by inoculating a rodent with the cells of a lymphoma causing cell line capable of infiltrating into the CNS or eye of the inoculated host.

    摘要翻译： 用CNS和眼渗透性淋巴瘤的非人动物模型是通过接种具有淋巴瘤的细胞的啮齿动物产生的，其能够渗透入接种宿主的CNS或眼睛的细胞系。