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17 条记录 (耗时 0.025 秒)

    Compositions and Methods of Topical Application and Transdermal Delivery of Botulinum Toxins without Reduced Non-Toxin Proteins
    1.
    发明申请
    Compositions and Methods of Topical Application and Transdermal Delivery of Botulinum Toxins without Reduced Non-Toxin Proteins 失效
    不减少非毒素蛋白的肉毒杆菌毒素的局部应用和透皮输送的组合物和方法

    公开(公告)号：US20070116724A1

    公开(公告)日：2007-05-24

    申请号：US11560555

    申请日：2006-11-16

    申请人： Jacob Waugh

    发明人： Jacob Waugh

    IPC分类号： A61K39/08

    CPC分类号： A61K8/99 ,  A61K8/64 ,  A61K9/0019 ,  A61K38/4893 ,  A61Q19/08 ,  Y02A50/469

    摘要： This invention relates to novel compositions of botulinum toxin that can be applied topically for various therapeutic, aesthetic and/or cosmetic purposes. The compositions may include botulinum toxin complexes, wherein the amounts of hemagglutinin, non-toxin non-hemagglutinin and/or exogenous albumin are selectively and independently reduced compared to conventional commercially available botulinum toxin. The compositions may further contain molecules that are not native to botulinum toxin and that bind non-covalently to the botulinum toxin complexes, thereby acting as skin-tropic “adhesion molecules” to improve the ability of the toxin complexes to adhere to and to penetrate the skin epithelium. The compositions have an improved safety profile compared to existing botulinum-containing compositions that are injected subcutaneously. Methods for the use of such compositions are also contemplated by this invention.

    摘要翻译： 本发明涉及可以局部应用于各种治疗，美学和/或美容目的的肉毒杆菌毒素的新型组合物。 组合物可以包括肉毒杆菌毒素复合物，其中与常规市售的肉毒杆菌毒素相比，血凝素，非毒素非血凝素和/或外源性白蛋白的量选择性和独立地降低。 组合物还可以含有对肉毒杆菌毒素不是天然的并且与肉毒杆菌毒素复合物非共价结合的分子，从而作为皮肤 - 热带的“粘附分子”，以提高毒素复合物粘附并穿透其的能力 皮肤上皮。 与现有的含有肉毒杆菌的皮下组合物相比，组合物具有改善的安全性。 本发明也考虑了使用这种组合物的方法。

    Compositions and methods for topical application and transdermal delivery of an oligopeptide
    7.
    发明申请
    Compositions and methods for topical application and transdermal delivery of an oligopeptide 有权
    用于局部应用和透皮递送寡肽的组合物和方法

    公开(公告)号：US20070037252A1

    公开(公告)日：2007-02-15

    申请号：US11368198

    申请日：2006-03-03

    申请人： Michael Dake ,  Jacob Waugh

    发明人： Michael Dake ,  Jacob Waugh

    IPC分类号： C12Q1/68 ,  C12P21/06

    CPC分类号： A61K9/7023 ,  A61K8/64 ,  A61K38/08 ,  A61Q7/00 ,  A61Q15/00 ,  C07K14/33

    摘要： The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged “backbone” having positively charged branching or “efficiency” groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.

    摘要翻译： 本发明涉及用于减少动物组织中突触传递的寡肽的透皮应用。 一方面，本发明涉及包含寡肽和​​任选的载体的组合物，其包含具有带正电荷的支化或“效率”基团的带正电荷的“骨架”，如本文所述。 最优选地，带正电荷的载体是长链带正电荷的多肽或带正电荷的非肽基聚合物，例如聚亚烷基亚胺。 本发明还涉及用于通过局部施用有效量的这种组合物，优选给予需要这种治疗的受试者或患者的皮肤来产生减少组织中突触传递的生物学效应的方法。 本发明还提供用于制备或配制包含寡肽和​​任选的载体的组合物的试剂盒，以及产生可用制剂所需的其它物质，或可以依次用于制备这种制剂的预混物。

    Method for delivering polymerized therapeutic agent compositions and compositions thereof
    8.
    发明申请
    Method for delivering polymerized therapeutic agent compositions and compositions thereof 审中-公开
    用于递送聚合治疗剂组合物及其组合物的方法

    公开(公告)号：US20050074425A1

    公开(公告)日：2005-04-07

    申请号：US10884226

    申请日：2004-07-02

    申请人： Jacob Waugh ,  Mahmood Razavi ,  Ceron Rhee ,  Clifford Bryant

    发明人： Jacob Waugh ,  Mahmood Razavi ,  Ceron Rhee ,  Clifford Bryant

    IPC分类号： A61K31/74 ,  A61K45/06 ,  A61K38/17 ,  A61K31/785 ,  C08G63/48

    CPC分类号： A61K45/06 ,  A61K31/74 ,  A61K2300/00

    摘要： A method for delivering polymerized therapeutic agents and their compositions are disclosed. The various polymers take advantage of the functional domains found in a variety of therapeutic agents. The polymerized therapeutic agent compositions are prepared by covalently linking the agent to a biocompatible backbone either directly or through backbone conjugates/monomers. The polymerized therapeutic agent compositions of the invention have highly desirable properties, which make them particularly well suited for use in biological and biomedical applications.

    摘要翻译： 公开了一种递送聚合治疗剂及其组合物的方法。 各种聚合物利用在各种治疗剂中发现的功能域。 聚合的治疗剂组合物通过将试剂直接或通过主链共轭物/单体共价连接到生物相容的主链来制备。 本发明的聚合治疗剂组合物具有非常理想的性质，使得它们特别适用于生物和生物医学应用。