公开(公告)号：US20090018325A1

公开(公告)日：2009-01-15

申请号：US12281630

申请日：2007-03-15

Applicant: Jacques Cercus ,  Michael Foulkes ,  Thomas Heinz ,  Daniel Niederer ,  Beat Schmitz

Inventor： Jacques Cercus ,  Michael Foulkes ,  Thomas Heinz ,  Daniel Niederer ,  Beat Schmitz

IPC: C07H19/00

CPC classification number: C07H19/073

Abstract: A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now, is possible.

Abstract translation: 已经发现一种新的方法生产2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶作为新的有用的中间体化合物。 已经进一步发现一种从2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶产生胸苷的新方法。 根据这些方法，迄今为止难以合成的各种L-核酸衍生物的合成是可能的。

公开(公告)号：US20080249318A1

公开(公告)日：2008-10-09

申请号：US11893481

申请日：2007-08-16

Applicant: Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

Inventor： Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

IPC: C07D209/34 ,  C07C227/22 ,  C07C211/55 ,  C07C233/01

CPC classification number: C07C211/52 ,  C07C211/56 ,  C07C227/22 ,  C07C229/42 ,  C07C233/15 ,  C07C235/16 ,  C07C235/24 ,  C07C2601/16 ,  C07D209/34

Abstract: A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Abstract translation: 制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。 式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。

公开(公告)号：US07906677B2

公开(公告)日：2011-03-15

申请号：US12436991

申请日：2009-05-07

Applicant: Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

Inventor： Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

IPC: C07C227/22 ,  C07C209/62

CPC classification number: C07C211/52 ,  C07C211/56 ,  C07C227/22 ,  C07C229/42 ,  C07C233/15 ,  C07C235/16 ,  C07C235/24 ,  C07C2601/16 ,  C07D209/34

Abstract: A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Abstract translation: 制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。 式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。

公开(公告)号：US20090275758A1

公开(公告)日：2009-11-05

申请号：US12436991

申请日：2009-05-07

Applicant: Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

Inventor： Murat Acemoglu ,  Thomas Allmendinger ,  John Vincent Calienni ,  Jacques Cercus ,  Olivier Loiseleur ,  Gottfried Sedelmeier ,  David Xu

IPC: C07C209/62 ,  C07D209/34 ,  C07C233/07

CPC classification number: C07C211/52 ,  C07C211/56 ,  C07C227/22 ,  C07C229/42 ,  C07C233/15 ,  C07C235/16 ,  C07C235/24 ,  C07C2601/16 ,  C07D209/34

Abstract: A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Abstract translation: 制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。 式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。