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公开(公告)号：US08720501B2
公开(公告)日：2014-05-13
申请号：US12734501
申请日：2008-11-06
申请人： Jacques Thilly
发明人： Jacques Thilly
IPC分类号： B67C3/04
CPC分类号： B65B3/003 , A61J1/20 , A61J1/201 , A61J1/2075 , A61M5/3291 , A61M2207/00
摘要： A hollow needle comprising a shaft having a distal portion suitable for passing through an elastomer closure of a container, said shaft extending in a longitudinal direction and having a central longitudinal axis, and having an internal longitudinal conduit therein for the flow of liquid and one or more orifices communicating between the conduit and the exterior of the needle, the distal portion of the shaft being provided with a pointed end that has a profile comprising a cutting edge in the form of two part cutting edges converging in the longitudinal direction to meet at the needle point, each part cutting edge extending in a straight line in a widthways direction across a plane including the central longitudinal axis, on both widthways sides of the cutting edge the pointed end having a profile which is a non-cutting surface, wherein the pointed end of the needle tapers from an outer surface of said distal portion toward the point of the needle, and the distance, measured in a further plane defined by said two part cutting edges between the outermost ends of said part cutting edges, is smaller than the largest outer dimension of said distal portion, measured perpendicular to said central axis in said further plane.
摘要翻译： 一种空心针，其包括具有适于穿过容器的弹性体封闭件的远侧部分的轴，所述轴沿纵向方向延伸并具有中心纵向轴线，并且在其中具有用于液体流动的内部纵向导管， 更多的孔在针的导管和外部之间连通，所述轴的远侧部分设置有尖端，所述尖端具有轮廓，所述轮廓包括沿着纵向方向会聚的两部分切削刃的形式的切削刃， 针尖，每个切削刃沿宽度方向延伸穿过包括中心纵向轴线的平面，在切削刃的两个宽度侧上，尖端具有非切削表面的轮廓，其中尖头 针的端部从所述远端部分的外表面朝向针的位置逐渐变细，并且距离 由所述部分切割刃的最外端之间的所述两部分切割刃所限定的平面，小于在所述另一平面中垂直于所述中心轴线测量的所述远端部分的最大外部尺寸。
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公开(公告)号：US07851538B2
公开(公告)日：2010-12-14
申请号：US10566615
申请日：2004-08-02
CPC分类号： C08J3/226 , A61J1/1468 , B65D45/18 , B65D51/002 , C08J2321/00 , C08J2423/00 , C08K5/0041 , C08L53/02 , C08L53/025 , Y10T428/1352 , C08L21/00 , C08L2666/04 , C08L2666/02
摘要： A novel elastomer material having an absorption coefficient for laser light of 0.5-2.5 mm−1, preferably being a base thermoplastic elastomer compounded with a colorant which comprises a Pantone 4597C pigment mixed with a carrier material. The elastomer is suited for use as a pharmaceutical vial closure which can be punctured by a filling needle and the puncture hole heat sealed by a focused laser.
摘要翻译： 具有0.5-2.5mm -1的激光吸收系数的新型弹性体材料，优选为与着色剂复合的基础热塑性弹性体，其包含与载体材料混合的Pantone 4597C颜料。 该弹性体适合用作可由填充针刺穿的药物瓶盖，以及由聚焦激光器热封的穿刺孔。
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公开(公告)号：US20090158612A1
公开(公告)日：2009-06-25
申请号：US11718034
申请日：2005-10-25
CPC分类号： B65D51/241 , F26B5/06
摘要： A process for preparing a lyophilized material, providing a container having a penetrable envelope and containing the material in a carrier liquid, whereby the penetrable region is penetrated with a penetrator which provides a conduit through the envelope, and the carrier liquid id evaporated out of the container via the conduit, after which the penetrator is withdrawn. Apparatus suitable for performing the process is also disclosed.
摘要翻译： 一种制备冻干材料的方法，提供具有可穿透外壳并容纳载体液体的容器的容器，由此可穿透区域穿透穿透器，该穿透器通过外壳提供导管，并将载体液体id从 容器经过导管，之后将穿透器取出。 还公开了适合于执行该过程的装置。
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公开(公告)号：US20080196437A1
公开(公告)日：2008-08-21
申请号：US11568882
申请日：2005-05-09
IPC分类号： F25D3/11
摘要： An apparatus for shell freezing a liquid content in a container, comprising an endless loop conveyor having a conveying length adapted to convey plural containers such as pharmaceutical vials, incorporating plural rollers to spin the containers as they are conveyed by the conveyor, and a return length, along at least part of the return length the rollers are immersed in a cooling liquid at a temperature below the freezing point of the liquid content of the containers, and along the conveying length the rollers are entirely above the surface of the cooling liquid. A preferred cooling liquid is liquid nitrogen, the evaporating vapour of which can be used to shield vials on the conveying length.
摘要翻译： 一种用于壳体冷冻容器中的液体含量的装置，包括具有适于传送多个容器（例如药物瓶）的输送长度的环形输送机，该输送长度包括多个辊子，以便当它们被输送机输送时旋转容器，并且返回长度 沿着返回长度的至少一部分，辊在低于容器的液体含量的凝固点的温度下浸入冷却液中，并且沿着输送长度，辊完全在冷却液表面上方。 优选的冷却液体是液氮，其蒸发蒸汽可用于在输送长度上屏蔽小瓶。
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公开(公告)号：US07365343B2
公开(公告)日：2008-04-29
申请号：US10546682
申请日：2004-02-19
CPC分类号： A61L2/087 , A61L2/0011 , A61L2202/122 , B65B3/003 , B65B7/161 , B65B55/025 , B65B55/08
摘要： Apparatus for introducing a medicament into containers, especially vials, in which the containers are passed through an enclosure and exposed therein to a sterilising electron beam. The containers are then conveyed to a filling station situated outside the enclosure at which a wall part of the container is punctured with a filling needle and medicament introduced into the container via the needle then withdrawing the needle. Preferred apparatus also includes means for heat sealing the puncture site. A corresponding process is disclosed.
摘要翻译： 用于将药物引入容器，特别是小瓶中的装置，其中容器通过外壳并暴露于灭菌电子束中。 然后将容器输送到位于外壳外部的填充站，容器的壁部分用填充针刺穿，填充针通过针引入容器中，然后抽出针。 优选的装置还包括用于热封穿刺部位的装置。 公开了相应的方法。
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6.发明授权Closure system for a vial, vial, method of closing and filling a vial and stand for a vial 有权瓶子封闭系统，小瓶，关闭和灌装小瓶并放置一个小瓶的方法公开(公告)号：US07946437B2
公开(公告)日：2011-05-24
申请号：US10524886
申请日：2003-08-15
CPC分类号： B65D51/002 , A61J1/1425 , A61J1/1468 , A61J1/18 , A61M2207/00 , B65D23/001
摘要： A closure system for a pharmaceutical vial, comprising an elastomer closure part, a clamp part which holds the closure part in engagement with the mouth of the vial, and a cover part which engages with the clamp part. The interior of the closure part is profiled to minimize retention of residual liquid therein.
摘要翻译： 一种用于药物瓶的封闭系统，包括弹性体闭合部分，夹持部分，其保持封闭部分与小瓶的口部接合;以及盖部分，其与夹持部分接合。 封闭部件的内部成型为使残留液体的保留最小化。
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公开(公告)号：USD598124S1
公开(公告)日：2009-08-11
申请号：US29303514
申请日：2008-02-11
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公开(公告)号：US20090134114A1
公开(公告)日：2009-05-28
申请号：US11913996
申请日：2006-05-15
申请人： Jacques Thilly
发明人： Jacques Thilly
CPC分类号： B65B3/003 , B65D51/002
摘要： A closure system for a vial comprising: an elastic closure part to engage the mouth opening, a clamp part to hold the closure part in a closing relationship with the mouth opening, the clamp part defining an upper aperture through which a region of the upper surface of the closure part is exposed when the clamp part is engaged with the vial, a cover part to engage the clamp part to cover the exposed region, the cover part engaging with the closure part to provide two or more concentric ring-shaped seals, at least part of the cover part being removable from the vial to allow access to the closure.
摘要翻译： 一种用于小瓶的闭合系统，包括：弹性闭合部分，用于接合开口;夹持部分，用于将闭合部分保持在与开口处于关闭关系的关系中;夹紧部分限定上部开口，上表面的一个区域 当夹具部分与小瓶接合时，封盖部分露出，盖部分与夹紧部分接合以覆盖暴露区域，盖部分与封闭部分接合以提供两个或更多个同心环形密封件 盖部分的至少一部分可从小瓶移除以允许接近封闭件。
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9.发明授权System for providing communication between the interior and the exterior of a compartment 有权用于在隔间的内部和外部之间提供通信的系统公开(公告)号：US07431352B2
公开(公告)日：2008-10-07
申请号：US11682515
申请日：2007-03-06
CPC分类号： G21F7/005 , G21F7/047 , G21Y2002/206 , G21Y2002/30 , G21Y2004/30 , Y10T292/03 , Y10T292/202 , Y10T292/225 , Y10T403/595
摘要： A system for making a connection between the interior and exterior of a compartment, comprising a door opening through the compartment wall, a connector body which can engage with the wall, and having a connection port through it, and a removable cover on the connector body. The body is engaged with the door opening, and an inner door within the compartment engages and removes the cover. A preferred construction creates a single line of confidence seal. The system is particularly suited for sterile compartments.
摘要翻译： 一种用于在隔室的内部和外部之间形成连接的系统，包括通过隔室壁的门开口，可与壁接合并具有通过其的连接端口的连接器主体，以及连接器本体上的可移除盖 。 主体与门开口接合，并且隔室内的内门接合并移除盖。 一个优选的结构形成了一行置信密封。 该系统特别适用于无菌隔间。
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公开(公告)号：US07252308B2
公开(公告)日：2007-08-07
申请号：US10495398
申请日：2002-11-12
申请人： Jacques Thilly
发明人： Jacques Thilly
CPC分类号： A61M39/18 , A61M2039/1027 , A61M2039/1094 , Y10S604/905
摘要： A connector for forming a sterile connection between two tubes, comprising first and second parts which comprise connectable conduits and which can mate, first and second covers which can be removed from the so-mated parts to expose connectable ends of the first and second conduits, so that the conduits can then be connected.
摘要翻译： 一种用于在两个管之间形成无菌连接的连接器，包括第一和第二部分，该第一和第二部分包括可连接的导管并且可配合第一和第二盖，第一和第二盖可以从所配合的部分移除以暴露第一和第二导管的可连接端部， 从而可以连接导管。
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