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公开(公告)号：US08765729B2
公开(公告)日：2014-07-01
申请号：US11558408
申请日：2006-11-09
Applicant: James D. Crapo , Brian J. Day , Ines Batinic-Haberle , Richard Gammans , Zeljko Vusjaskovic
Inventor： James D. Crapo , Brian J. Day , Ines Batinic-Haberle , Richard Gammans , Zeljko Vusjaskovic
IPC: A61K31/555 , A61K31/33
CPC classification number: A61K31/555 , A61K31/409 , A61K41/00
Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
Abstract translation: 本发明一般涉及癌症治疗，特别涉及使用低分子量抗氧化剂（例如超氧化物歧化酶（SOD）的模拟物）作为活性剂或作为化学治疗剂的预防或治疗癌症的方法， 和/或无线电保护。 本发明还涉及适用于这种方法的化合物和组合物。
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公开(公告)号：US08217026B2
公开(公告)日：2012-07-10
申请号：US12885198
申请日：2010-09-17
Applicant: James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
Inventor： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC: A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC classification number: A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Abstract translation: 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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3.发明申请Oxidant Scavengers for Treatment of Diabetes or Use in Transplantation or Induction of Immune Tolerance 有权用于治疗糖尿病或用于移植或诱导免疫耐受的氧化剂清除剂公开(公告)号：US20110105452A1
公开(公告)日：2011-05-05
申请号：US12941933
申请日：2010-11-08
Applicant: Jon D. Piganelli , Kathryn Haskins , Sonia C. Flores , James D. Crapo , Brian J. day , Ronald G. Gill , Richard Gammans , Manisha Patel
Inventor： Jon D. Piganelli , Kathryn Haskins , Sonia C. Flores , James D. Crapo , Brian J. day , Ronald G. Gill , Richard Gammans , Manisha Patel
IPC: A61K31/555 , A61K31/4439 , A61P3/10 , A61P37/00
CPC classification number: A61K31/555 , A61K31/409
Abstract: The present invention relates, in one embodiment, to a method of preventing or treating diabetes using low molecular weight antioxidants. In a further embodiment, the invention relates to a method of protecting and/or enhancing viability of cells/tissues/organs during isolation (harvesting), preservation, expansion and/or transplantation. In yet another embodiment, the present invention relates to a method of inducing immune tolerance. The invention also relates to compounds and compositions suitable for use in such methods.
Abstract translation: 本发明在一个实施方案中涉及使用低分子量抗氧化剂预防或治疗糖尿病的方法。 在另一个实施方案中，本发明涉及在分离（收获），保存，扩增和/或移植期间保护和/或增强细胞/组织/器官的活力的方法。 在另一个实施方案中，本发明涉及诱导免疫耐受的方法。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US07820644B2
公开(公告)日：2010-10-26
申请号：US11424662
申请日：2006-06-16
Applicant: James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
Inventor： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC: A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC classification number: A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Abstract translation: 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US07189707B2
公开(公告)日：2007-03-13
申请号：US10349171
申请日：2003-01-23
Applicant: James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
Inventor： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC: A61K31/409
CPC classification number: A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Abstract translation: 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08980574B2
公开(公告)日：2015-03-17
申请号：US14004057
申请日：2012-03-09
Applicant: James D. Crapo , A. Mario Q. Marcondes , H. Joachim Deeg
Inventor： James D. Crapo , A. Mario Q. Marcondes , H. Joachim Deeg
CPC classification number: A61K38/57 , A61K9/0019 , A61K38/00 , A61K38/55 , C07K14/8125
Abstract: Embodiments described herein relate to compositions, methods and uses for alpha-1 antitrypsin (AAT) or derivatives or analogs or peptides or mutants thereof for treating a subject exposed to radiation. In certain embodiments, AAT or derivatives thereof or analogs thereof can be used to modulate adverse effects of radiation therapy on subjects undergoing treatment for cancer. In other embodiments, compositions disclosed herein can be used for treating a subject having been exposed to non-therapeutic or accidental radiation. Some embodiments reported herein concern compositions and methods for enhancing radiotherapy. Certain embodiments relate to methods and compositions for preventing or reducing radiation exposure-induced cellular damage in a subject.
Abstract translation: 本文描述的实施方案涉及用于治疗暴露于辐射的受试者的α-1抗胰蛋白酶（AAT）或其衍生物或类似物或肽或其突变体的组合物，方法和用途。 在某些实施方案中，AAT或其衍生物或其类似物可用于调节放射治疗对接受癌症治疗的受试者的不利影响。 在其它实施方案中，本文公开的组合物可用于治疗暴露于非治疗或意外辐射的受试者。 本文报道的一些实施方案涉及用于增强放射治疗的组合物和方法。 某些实施方案涉及用于预防或减少受试者中辐射暴露诱导的细胞损伤的方法和组合物。
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公开(公告)号：US08546562B2
公开(公告)日：2013-10-01
申请号：US13457232
申请日：2012-04-26
Applicant: James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
Inventor： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC: C07D487/22 , A01N55/02
CPC classification number: A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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公开(公告)号：US06583132B1
公开(公告)日：2003-06-24
申请号：US09201722
申请日：1998-11-30
Applicant: James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
Inventor： James D. Crapo , Irwin Fridovich , Tim Oury , Brian J. Day , Rodney J. Folz , Bruce A. Freeman , Michael P. Trova , Ines Batinic-Haberle
IPC: A61K31555
CPC classification number: A61K31/555 , A61K31/00
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Abstract translation: 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂和细胞外水平的方法，从而进一步调节这些氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。
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公开(公告)号：US06479477B1
公开(公告)日：2002-11-12
申请号：US09296615
申请日：1999-04-23
Applicant: James D. Crapo , Brian J. Day , Polivina Jolicia F. Gauuan , Anthony D. Pechulis, Jr. , Michael P. Trova
Inventor： James D. Crapo , Brian J. Day , Polivina Jolicia F. Gauuan , Anthony D. Pechulis, Jr. , Michael P. Trova
IPC: A61K5104
CPC classification number: C07D487/22
Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.
Abstract translation: 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。 本发明的化合物包括式I化合物。
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公开(公告)号：US09938353B2
公开(公告)日：2018-04-10
申请号：US14125135
申请日：2012-06-22
Applicant: Charles Dinarello , James D Crapo , Soohyun Kim
Inventor： Charles Dinarello , James D Crapo , Soohyun Kim
CPC classification number: C07K16/40 , A61K38/57 , C07K14/8125 , C07K2319/30 , C12N15/62
Abstract: Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment.
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