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    Nanoelectronic-enzyme linked immunosorbent assay system and method
    1.
    发明授权
    Nanoelectronic-enzyme linked immunosorbent assay system and method 有权
    纳米电子酶联免疫吸附测定系统及方法

    公开(公告)号：US09188594B2

    公开(公告)日：2015-11-17

    申请号：US12535396

    申请日：2009-08-04

    申请人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

    发明人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

    IPC分类号： G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/555 ,  G01N2333/98

    摘要： The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

    摘要翻译： 本发明涉及一种用于测定溶液中特定化合物的存在的装置和方法。 该装置包括在至少第一和第二接触之间具有导电路径的纳米传感器。 该装置还包括适于结合附着于纳米传感器的溶液中的特定化合物的第一受体，以及也适于结合特定化合物而第二受体，而特异性化合物与第一受体结合。 第二受体与添加到溶液中的酶连接。 当将具有第二受体的溶液加入到装置中，并且随后将另外作为酶底物的第二化合物加入到溶液中时，测量第二化合物施用前后装置的电性能差异 表明该溶液中特定化合物的存在。

    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces
    4.
    发明授权
    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces 有权
    CMOS兼容的硅纳米线传感器，具有生化和蜂窝接口

    公开(公告)号：US09076665B2

    公开(公告)日：2015-07-07

    申请号：US12517230

    申请日：2007-12-06

    申请人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    发明人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    IPC分类号： G01N27/414 ,  H01L29/06 ,  B82Y10/00 ,  H01L29/04 ,  H01L29/16

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  G01N27/4146 ,  H01L29/045 ,  H01L29/0673 ,  H01L29/16

    摘要： The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.

    摘要翻译： 本文所述的系统和方法包括适于感测化学和生物物质的传感器。 传感器包括形成在衬底中或衬底上的半导体层和形成在半导体层中的具有纳米级尺寸的沟道，其中该结构在半导体层上的第一接触和第二接触之间形成导电通路。 在某些优选实施例中，纳米尺度通道具有具有有效宽度和暴露侧面的梯形横截面，其中有效宽度被选择为具有与其半导体材料的德拜长度（LD）相同的数量级 形成半导体层。