公开(公告)号：US07315758B2

公开(公告)日：2008-01-01

申请号：US10860557

申请日：2004-06-03

申请人： Krzysztof C. Kwiatkowski ,  Ryan T. Hayes ,  James W. Magnuson ,  Anthony Giletto

发明人： Krzysztof C. Kwiatkowski ,  Ryan T. Hayes ,  James W. Magnuson ,  Anthony Giletto

IPC分类号： A61N1/30

CPC分类号： A61M37/0015 ,  A61K9/0009 ,  A61K9/0021 ,  A61K9/06 ,  A61K9/16 ,  A61M2037/0023 ,  A61N1/306 ,  A61N1/325

摘要： A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.

摘要翻译： 用于将治疗剂透皮递送至生物受试者的装置，其包括第一电极，所述第一电极包括第一导电微突出阵列，用于提供通过所述受试者的皮肤部分的电连通至第二电极，所述第二电极包括第二阵列的导电微突出物 。 此外，可以提供用于保持围绕第一电极的治疗剂的储存器和用于在第一和第二电极之间提供指数衰减脉冲的脉冲发生器。 一种方法包括以两个阵列的导电微突出物刺穿角质层皮肤层的步骤，将治疗剂包封在生物相容的带电荷的载体中，用治疗剂包围导电微突出物，在导电微突出体的两个阵列之间产生指数衰减脉冲 以产生不均匀的电场并通过皮肤的角质层电动驱动治疗剂。

公开(公告)号：US6145244A

公开(公告)日：2000-11-14

申请号：US210509

申请日：1998-12-11

申请人： Dalibor Hodko ,  John Van Hyfte ,  Adrain Denvir ,  James W. Magnuson

发明人： Dalibor Hodko ,  John Van Hyfte ,  Adrain Denvir ,  James W. Magnuson

IPC分类号： A01B47/00 ,  B09C1/08 ,  B09C1/10 ,  C22B3/04 ,  C22B7/00 ,  A01B79/00 ,  A01B79/02 ,  A01G1/00 ,  A01G7/04 ,  C21B15/00

CPC分类号： C22B7/006 ,  A01B47/00 ,  B09C1/085 ,  B09C1/105 ,  C22B3/045 ,  Y02P10/234

摘要： The present invention relates to a method of remediating soil, water, and other porous media contaminated with organic and/or inorganic contaminants using plants in conjunction with an electric field applied through the medium to control movement of the contaminants and enhance removal of the contaminants from the medium. Applying an electric field in soil induces electromigration (movement of ions in the pore fluid), as well as electroosmosis (movement of pore water) and electrophoresis (movement of charged particles in soil such as colloids). In the present invention these phenomena are beneficially utilized to control the transport of charged and/or non-charged contaminants in soil within the plant root zone (rhizosphere) and to bring contaminants into the root zone, perhaps from a contaminated zone located deeper in the soil than the root zone. The effectiveness of the phytoremediation is also enhanced by preventing the soil from becoming so strongly acidic or basic as to kill the plants. The present invention significantly extends the utility of phytoremediation to cleanup of soils with deeper contamination plumes than are typically accessible to the roots of plants.

摘要翻译： 本发明涉及一种补救有机和/或无机污染物污染的土壤，水和其他多孔介质的方法，其中使用植物结合通过介质施加的电场来控制污染物的移动并增强污染物的去除 介质。 在土壤中施加电场会导致电迁移（孔隙流体中的离子运动）以及电渗（孔隙水的移动）和电泳（带电粒子在诸如胶体的土壤中的移动）。 在本发明中，这些现象有利地用于控制植物根区（根际）内的土壤中带电和/或非带电污染物的运输，并将污染物带入根区，可能来自位于 土壤比根区。 通过防止土壤变得如此强烈的酸性或碱性以杀死植物，也提高了植物修复的有效性。 本发明显着地延长了植物修复对清除具有比植物根部通常可达的更深的污染羽流的土壤的效用。