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公开(公告)号:US07315758B2
公开(公告)日:2008-01-01
申请号:US10860557
申请日:2004-06-03
IPC分类号: A61N1/30
CPC分类号: A61M37/0015 , A61K9/0009 , A61K9/0021 , A61K9/06 , A61K9/16 , A61M2037/0023 , A61N1/306 , A61N1/325
摘要: A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.
摘要翻译: 用于将治疗剂透皮递送至生物受试者的装置,其包括第一电极,所述第一电极包括第一导电微突出阵列,用于提供通过所述受试者的皮肤部分的电连通至第二电极,所述第二电极包括第二阵列的导电微突出物 。 此外,可以提供用于保持围绕第一电极的治疗剂的储存器和用于在第一和第二电极之间提供指数衰减脉冲的脉冲发生器。 一种方法包括以两个阵列的导电微突出物刺穿角质层皮肤层的步骤,将治疗剂包封在生物相容的带电荷的载体中,用治疗剂包围导电微突出物,在导电微突出体的两个阵列之间产生指数衰减脉冲 以产生不均匀的电场并通过皮肤的角质层电动驱动治疗剂。
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公开(公告)号:US06569353B1
公开(公告)日:2003-05-27
申请号:US09096435
申请日:1998-06-11
IPC分类号: C09K300
CPC分类号: A62D3/38 , A61K8/25 , A61K8/46 , A61Q17/00 , A62D2101/02 , B01J20/06 , B01J20/08 , B01J20/103
摘要: The present invention provides a universal decontamination formulation and method for detoxifying chemical warfare agents (CWA's) and biological warfare agents (BWA's) without producing any toxic by-products, as well as, decontaminating surfaces that have come into contact with these agents. The formulation includes a sorbent material or gel, a peroxide source, a peroxide activator, and a compound containing a mixture of KHSO5, KHSO4 and K2SO4. The formulation is self-decontaminating and once dried can easily be wiped from the surface being decontaminated. A method for decontaminating a surface exposed to chemical or biological agents is also disclosed.
摘要翻译: 本发明提供了在不产生任何有毒副产物的情况下对化学战剂(CWA)和生物战剂(BWA)进行解毒的通用去污配方和方法,以及与这些试剂接触的表面去污。 制剂包括吸附剂材料或凝胶,过氧化物源,过氧化物活化剂和含有KHSO 5,KHSO 4和K 2 SO 4的混合物的化合物。 制剂是自净化的,一旦干燥即可从被去污的表面容易地擦去。 还公开了暴露于化学或生物制剂的表面去污的方法。
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公开(公告)号:US06518307B2
公开(公告)日:2003-02-11
申请号:US09981669
申请日:2001-10-17
IPC分类号: A01N3700
CPC分类号: A61K33/04 , A61K31/19 , A61K31/191 , A61K31/327 , A61K33/40 , A61K45/06 , A61K2300/00
摘要: The present invention provides a method for controlling microbial populations in the gastrointestinal tract of animals. The method comprises the step of orally administering an effective amount of a peracid to an animal. Percarboxylic acids useful in this invention include peracetic acid, perpropionic acid, perbutyric acid, peroctanoic acid, perglycolic acid, perglutaric acid, persuccinic acid, perlactic acid, percitric acid, perdecanoic acid or mixtures thereof. These percarboxylic acids have been found to provide good antimicrobial action with good stability in aqueous streams. In addition to peracetic, peroctanoic and perdecanoic, particularly preferred percarboxylic acids include perpropionic, perbutyric, perglycolic, perlactic and percitric acids.
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4.
公开(公告)号:US06582971B1
公开(公告)日:2003-06-24
申请号:US09642796
申请日:2000-08-21
申请人: Waheguru Pal Singh , Anthony Giletto , David Gaskin , James Fyffe
发明人: Waheguru Pal Singh , Anthony Giletto , David Gaskin , James Fyffe
IPC分类号: G01N33543
CPC分类号: C08F8/00 , G01N2600/00 , Y10T436/10 , C08F20/00
摘要: A method for molecular imprinting polymers with large biomolecules. The imprinted polymer composite is made by the interfacial polymerization of a monomer in the presence of the print molecule and host polymer. Since polymerization occurs at the interface between an organic solvent and an aqueous solution, the print molecule can be disposed in the phase that allows the print molecule to remain in its native configuration. The choice of the host polymer and the monomer to be polymerized can be varied to enhance the specificity of the composite toward the biomolecule that is selected to be imprinted.
摘要翻译: 一种具有大生物分子的分子印迹聚合物的方法。 印迹聚合物复合材料通过单体在印刷分子和主体聚合物存在下的界面聚合制备。 由于聚合发生在有机溶剂和水溶液之间的界面处,所以印刷分子可以以允许印刷分子保持其天然构型的相位来设置。 可以改变主体聚合物和待聚合的单体的选择,以增强复合材料对选择被印迹的生物分子的特异性。
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公开(公告)号:US06468953B1
公开(公告)日:2002-10-22
申请号:US09631867
申请日:2000-08-03
申请人: G. Duncan Hitchems , Steven Drabek , Anthony Giletto , Charles Blankenburg , Kyle B. Uselton , Jennifer Schultz-Bathurst , Shivaun Archer
发明人: G. Duncan Hitchems , Steven Drabek , Anthony Giletto , Charles Blankenburg , Kyle B. Uselton , Jennifer Schultz-Bathurst , Shivaun Archer
IPC分类号: C11D1700
CPC分类号: C11D3/48 , A01N59/00 , A61L2/202 , C11D7/02 , C11D7/261 , C11D7/265 , A01N37/02 , A01N31/02 , A01N2300/00
摘要: The invention relates to the formation of antimicrobial solutions formed by ozonating a liquid containing organic precursor molecules. The preferred organic precursor molecules include carboxylic acids, most particularly octanoic acid with or without acetic acid, and alcohols, most particularly greater than 80 weight percent ethanol. The ozonating step is preferably performed with minimal or no water present in the liquid containing the organic precursors. After ozonation is complete, the ozonated liquid may be diluted with water or other solvent to form a use solution for contacting and cleaning a microbially contaminated surface or other medium.
摘要翻译: 本发明涉及通过臭氧化含有有机前体分子的液体形成的抗微生物溶液的形成。 优选的有机前体分子包括羧酸,最特别是具有或不具有乙酸的辛酸,以及醇,最特别地大于80重量%的乙醇。 臭氧化步骤优选在含有有机前体的液体中存在最少或不存在水的情况下进行。 臭氧化完成后,臭氧化液体可以用水或其它溶剂稀释,形成用于接触和清洁微生物污染的表面或其他介质的用途溶液。
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公开(公告)号:US20050273046A1
公开(公告)日:2005-12-08
申请号:US10860557
申请日:2004-06-03
CPC分类号: A61M37/0015 , A61K9/0009 , A61K9/0021 , A61K9/06 , A61K9/16 , A61M2037/0023 , A61N1/306 , A61N1/325
摘要: A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.
摘要翻译: 用于将治疗剂透皮递送至生物受试者的装置,其包括第一电极,所述第一电极包括第一导电微突出阵列,用于提供通过所述受试者的皮肤部分的电连通至第二电极,所述第二电极包括第二阵列的导电微突出物 。 此外,可以提供用于保持围绕第一电极的治疗剂的储存器和用于在第一和第二电极之间提供指数衰减脉冲的脉冲发生器。 一种方法包括以两个阵列的导电微突出物刺穿角质层皮肤层的步骤,将治疗剂包封在生物相容的带电荷的载体中,用治疗剂包围导电微突出物,在导电微突出体的两个阵列之间产生指数衰减脉冲 以产生不均匀的电场并通过皮肤的角质层电动驱动治疗剂。
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7.
公开(公告)号:US06342528B1
公开(公告)日:2002-01-29
申请号:US09487966
申请日:2000-01-18
IPC分类号: A61K3119
CPC分类号: A61K33/04 , A61K31/19 , A61K31/191 , A61K31/327 , A61K33/40 , A61K45/06 , A61K2300/00
摘要: The invention is a process for preventing microbial growth in the digestive tract of living vertebrate animals, particularly food animals. Control of microbial growth is achieved by the step of applying a percarboxylic acid or a mixture of percarboxylic acids to an aqueous stream which is subsequently consumed orally by the animal. The formulation can also be mixed into food items or into particulate or similar materials, or packaged in ingestible capsules, whereby the active ingredient enters the body of the animal through the oral cavity through feeding behavior, or food scavenging, or particulate scavenging activities of the animal. Formulations may also be sprayed onto the outside of the animal and taken orally.
摘要翻译: 本发明是防止活的脊椎动物,特别是食用动物的消化道微生物生长的方法。 微生物生长的控制是通过将过羧酸或过羧酸的混合物施用到随后由动物口服消耗的水流中的步骤来实现的。 制剂也可以混合成食物或颗粒或类似物质,或包装在可摄入的胶囊中,由此活性成分通过进食行为或食物清除或者清除微粒的活性通过口腔进入动物体内 动物。 制剂也可以喷洒到动物的外部并口服。
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