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公开(公告)号：US20160185861A1
公开(公告)日：2016-06-30
申请号：US14981142
申请日：2015-12-28
Applicant: Felipe Bedoya , Saba Ghassemi , Carl H. June , Bruce L. Levine , Jan J. Melenhorst , Michael C. Milone , Daniel J. Powell, JR. , Zoe Zheng
Inventor： Felipe Bedoya , Saba Ghassemi , Carl H. June , Bruce L. Levine , Jan J. Melenhorst , Michael C. Milone , Daniel J. Powell, JR. , Zoe Zheng
IPC: C07K16/28 , A61K35/17 , C07K14/725 , C12N5/0783 , C12N9/12 , C07K14/705
CPC classification number: C07K16/2803 , A61K35/17 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/28 , C07K2317/14 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0087 , C12N5/0636 , C12N5/0638 , C12N9/1276 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12Y207/07049
Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
Abstract translation: 本发明提供了可以进行工程化以表达嵌合抗原受体（CAR）的免疫效应细胞（例如，T细胞，NK细胞）的制备方法，以及包含其的组合物和反应混合物的方法。
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2.发明申请公开(公告)号：US20180133296A1
公开(公告)日：2018-05-17
申请号：US15567156
申请日：2016-04-15
Applicant: David Maxwell Barrett , Felipe Bedoya , Saba Ghassemi , Carl H. June , Bruce L. Levine , Jan J. Melenhorst , Michael C. Milone , Daniel J. Powell, Jr. , Nathan Amar Singh , Zoe Zheng
Inventor： David Maxwell Barrett , Felipe Bedoya , Saba Ghassemi , Carl H. June , Bruce L. Levine , Jan J. Melenhorst , Michael C. Milone , Daniel J. Powell, Jr. , Nathan Amar Singh , Zoe Zheng
IPC: A61K39/00 , C07K16/28 , C07K14/705 , C07K14/725 , C12N5/0783
CPC classification number: A61K39/0011 , A61K35/17 , A61K38/50 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , C07K14/4748 , C07K14/705 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/28 , C07K16/2803 , C07K2317/622 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C12N5/0636 , C12N2501/2302 , C12N2501/2305 , C12N2501/2307 , C12N2501/2318 , C12Y305/01001 , A61K2300/00
Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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3.发明申请公开(公告)号：US20170306416A1
公开(公告)日：2017-10-26
申请号：US15517597
申请日：2015-10-07
Applicant: Felipe Bedoya , Hans Bitter , Jennifer Brogdon , Corin Dorfmeier , Abhishnek Garg , David Glass , Joan Mannick , Jan J. Melenhorst , Michael Milone , Leon Murphy , Elena Orlando , Nicholas Wilcox , Novartis AG , The Trustees of the University of Pennsylvania
Inventor： Felipe Bedoya , Hans Bitter , Jennifer Brogdon , Corin Dorfmeier , Abhishnek Garg , David Glass , Joan Mannick , Jan J. Melenhorst , Michael Milone , Leon Murphy , Elena Orlando , Nicholas Wilcox
IPC: C12Q1/68 , A61K39/00 , G01N33/574
Abstract: Cancer biomarkers and methods of using them are disclosed.
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Patent Agency Ranking
公开(公告)号：US11747346B2
公开(公告)日：2023-09-05
申请号：US15757123
申请日：2016-09-02
Applicant: The Trustees of the University of Pennsylvania , Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey
Inventor： Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey , Eric Lancaster , Adam David Cohen , Pamela Shaw
IPC: G01N33/53 , G01N33/68 , G01N33/50 , A61P37/00 , A61P29/00 , A61K31/675 , A61K35/17 , A61K39/395 , A61K45/06 , C07K14/725 , C07K14/705 , C07K16/28 , C12Q1/6876
CPC classification number: G01N33/6863 , A61K31/675 , A61K35/17 , A61K39/3955 , A61K45/06 , A61P29/00 , A61P37/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C12Q1/6876 , G01N33/5047 , G01N33/6866 , G01N33/6869 , G01N33/6893 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C12Q2600/106 , C12Q2600/158 , G01N2800/24 , G01N2800/50 , G01N2800/52 , G01N2800/7095
Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
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公开(公告)号：US20180258149A1
公开(公告)日：2018-09-13
申请号：US15760519
申请日：2016-09-16
Applicant: Gregory MOTZ , Frederic Dixon BUSHMAN , Joseph A. FRAIETTA , Carl H. JUNE , Jan J. MELENHORST , Christopher Loren NOBLES , Novartis AG , The Trustees of the University of Pennsylvania
Inventor： Gregory Motz , Frederic Dixon Bushman , Joseph A. Fraietta , Carl H. June , Jan J. Melenhorst , Christopher Loren Nobles , Regina M. Young
IPC: C07K14/47 , C12N9/02 , C07K14/705 , A61K35/17 , A61K39/395 , A61P35/00
CPC classification number: C07K14/4748 , A61K35/17 , A61K39/0011 , A61K39/39558 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61P35/00 , C07K14/70503 , C12N9/0069 , C12Y113/11
Abstract: The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
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公开(公告)号：US20210177896A1
公开(公告)日：2021-06-17
申请号：US16305728
申请日：2017-06-02
Applicant: David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang , Novartis AG , The Trustees of the University of Pennsylvania
Inventor： David L. Porter , Noelle Frey , Carl H. June , Simon Lacey , Fang Chen , Jan J. Melenhorst , Tetiana Taran , Karen Thudium Mueller , Patricia Wood , Yiyun Zhang
Abstract: The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.
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公开(公告)号：US20180252727A1
公开(公告)日：2018-09-06
申请号：US15757123
申请日：2016-09-02
Applicant: Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey , The Trustees of the University of Pennsylvania
Inventor： Alfred Garfall , Alex Ganetsky , Saar Gill , Simon Lacey , Jan J. Melenhorst , David Teachey
IPC: G01N33/68 , A61K45/06 , A61K39/395 , C07K16/28 , C07K14/705 , C07K14/725 , A61K35/17 , C12Q1/6876 , A61K31/675 , A61P37/00 , A61P29/00
CPC classification number: G01N33/6863 , A61K31/675 , A61K35/17 , A61K39/3955 , A61K45/06 , A61P29/00 , A61P37/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C12Q1/6876 , C12Q2600/106 , C12Q2600/158 , G01N33/5047 , G01N33/6866 , G01N33/6869 , G01N33/6893 , G01N2800/24 , G01N2800/50 , G01N2800/52 , G01N2800/7095
Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
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公开(公告)号：US20170137783A1
公开(公告)日：2017-05-18
申请号：US15216036
申请日：2016-07-21
Applicant: Felipe Bedoya , Saba Ghassemi , Carl H. June , Omkar U. Kawalekar , Bruce L. Levine , Jan J. Melenhorst , Michael Milone , Daniel J. Powell, JR. , Zoe Zheng
Inventor： Felipe Bedoya , Saba Ghassemi , Carl H. June , Omkar U. Kawalekar , Bruce L. Levine , Jan J. Melenhorst , Michael Milone , Daniel J. Powell, JR. , Zoe Zheng
IPC: C12N5/0783 , A61K35/17 , C07K14/705 , C07K16/18 , C12N5/00 , C07K16/28
Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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