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1.发明申请公开(公告)号：US20100222345A1
公开(公告)日：2010-09-02
申请号：US12376577
申请日：2007-08-08
申请人： Caroline Jean Diaz , Curt Dale Haffner , Jason Daniel Speake , Cunyu Zhang , Wendy Yoon Mills , Paul Kenneth Spearing , David John Cowan , Gary Martin Green
发明人： Caroline Jean Diaz , Curt Dale Haffner , Jason Daniel Speake , Cunyu Zhang , Wendy Yoon Mills , Paul Kenneth Spearing , David John Cowan , Gary Martin Green
IPC分类号： A61K31/4184 , C07D235/04 , C07D413/12 , C07D405/12 , C07D471/04 , C07D401/10 , A61K31/5377 , A61K31/4439 , A61K31/4725
CPC分类号： C07D235/08 , C07D209/08 , C07D231/56 , C07D263/56 , C07D401/04 , C07D417/04 , C07D471/04 , C07D487/04
摘要： This invention relates to novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy.
摘要翻译： 本发明涉及作为一种或多种阿片受体的拮抗剂或反向激动剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中的用途。
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2.发明授权公开(公告)号：US07442693B2
公开(公告)日：2008-10-28
申请号：US11569257
申请日：2005-05-27
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , A61K31/551 , A61P3/04
CPC分类号： C07D403/14 , C07D403/06
摘要： There is provided novel diazepines that function as agonists at the melanocortin 4 receptor and as agonists at the melanocortin 1 receptor, pharmaceutical compositions containing them, methods for their use in treatment, and processes for their preparation.
摘要翻译： 提供了作为黑皮质素4受体的激动剂和黑皮质素1受体的激动剂，含有它们的药物组合物，其用于治疗的方法及其制备方法的新型二氮杂。
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公开(公告)号：US08633175B2
公开(公告)日：2014-01-21
申请号：US12376580
申请日：2007-08-08
申请人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
发明人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
CPC分类号： C07C237/48 , A61K31/166 , A61K31/381 , A61K31/4406 , A61K31/4468 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C53/18 , C07C233/25 , C07C235/42 , C07C237/30 , C07C311/08 , C07C323/25 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D211/60 , C07D213/38 , C07D213/56 , C07D213/81 , C07D217/02 , C07D217/04 , C07D231/12 , C07D233/64 , C07D233/70 , C07D233/72 , C07D249/06 , C07D249/08 , C07D249/10 , C07D271/06 , C07D275/02 , C07D277/32 , C07D285/10 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/38 , C07D401/10 , C07D417/12
摘要： Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
摘要翻译： 作为一种或多种阿片受体的拮抗剂或反向激动剂的新型化合物，含有它们的药物组合物，其制备方法。
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公开(公告)号：US20110263629A1
公开(公告)日：2011-10-27
申请号：US13061972
申请日：2009-09-02
申请人： Jon-Paul Strachan , Balwinder Singh Bhatti , Anatoly Mazurov , Jozef Klucik , Yunde Xiao , Philip S. Hammond , David Kombo , Lan Miao , Jason Daniel Speake , Daniel Yohannes
发明人： Jon-Paul Strachan , Balwinder Singh Bhatti , Anatoly Mazurov , Jozef Klucik , Yunde Xiao , Philip S. Hammond , David Kombo , Lan Miao , Jason Daniel Speake , Daniel Yohannes
IPC分类号： A61K31/439 , A61P25/00 , A61P25/28 , A61P25/18 , A61P3/04 , A61P3/00 , A61P37/06 , A61P25/30 , A61P25/04 , C07D471/08 , A61P29/00
CPC分类号： C07D471/08
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。
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5.发明申请公开(公告)号：US20110124559A1
公开(公告)日：2011-05-26
申请号：US12376580
申请日：2007-08-08
申请人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
发明人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
IPC分类号： A61K38/18 , C07D249/08 , A61K38/22 , A61K31/4196 , A61P3/04 , A61P3/10 , A61P9/12 , A61P25/24 , A61P25/22 , A61P25/30
CPC分类号： C07C237/48 , A61K31/166 , A61K31/381 , A61K31/4406 , A61K31/4468 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C53/18 , C07C233/25 , C07C235/42 , C07C237/30 , C07C311/08 , C07C323/25 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D211/60 , C07D213/38 , C07D213/56 , C07D213/81 , C07D217/02 , C07D217/04 , C07D231/12 , C07D233/64 , C07D233/70 , C07D233/72 , C07D249/06 , C07D249/08 , C07D249/10 , C07D271/06 , C07D275/02 , C07D277/32 , C07D285/10 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/38 , C07D401/10 , C07D417/12
摘要： Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
摘要翻译： 作为一种或多种阿片受体的拮抗剂或反向激动剂的新型化合物，含有它们的药物组合物，其制备方法。
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公开(公告)号：US07939528B2
公开(公告)日：2011-05-10
申请号：US12089606
申请日：2006-10-12
申请人： Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
发明人： Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/416 , A61P3/00 , C07D235/04 , C07D231/56 , C07D401/02 , C07D211/06 , C07D413/02
CPC分类号： C07D235/06 , C07D231/56 , C07D235/10 , C07D401/12
摘要： The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or conditions in mammals, particularly humans. Methods of making and using such compounds are also disclosed.
摘要翻译： 本发明涉及作为阿片受体的拮抗剂或反向激动剂的新化合物。 这些化合物可用于治疗哺乳动物，特别是人中的肥胖症和相关疾病和/或病症。 还公开了制备和使用这些化合物的方法。
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公开(公告)号：US20090054431A1
公开(公告)日：2009-02-26
申请号：US12089606
申请日：2006-10-12
申请人： Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
发明人： Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
IPC分类号： A61K31/5377 , C07D235/04 , A61K31/4184 , C07D231/56 , A61K31/416 , C07D401/02 , A61P3/00 , A61P9/00 , A61P25/00 , A61K31/4439 , A61K31/47 , C07D211/06 , A61K31/454 , C07D413/02
CPC分类号： C07D235/06 , C07D231/56 , C07D235/10 , C07D401/12
摘要： The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or conditions in mammals, particularly humans. Methods of making and using such compounds are also disclosed.
摘要翻译： 本发明涉及作为阿片受体的拮抗剂或反向激动剂的新化合物。 这些化合物可用于治疗哺乳动物，特别是人中的肥胖症和相关疾病和/或病症。 还公开了制备和使用这些化合物的方法。
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