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公开(公告)号:US07723385B2
公开(公告)日:2010-05-25
申请号:US12392687
申请日:2009-02-25
申请人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
发明人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
IPC分类号: A01N37/34 , A01N33/02 , A01N33/18 , A01N33/24 , A01N27/00 , A61K31/275 , A61K31/135 , A61K31/04 , A61K31/015 , C07C255/00 , C07C321/00 , C07C323/00 , C07C381/00 , C07C221/00 , C07C223/00 , C07C225/00
CPC分类号: C07C255/58 , C07C2601/02 , C07C2601/14
摘要: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的非甾体化合物,以及制备和使用这些化合物的方法。
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公开(公告)号:US07514470B2
公开(公告)日:2009-04-07
申请号:US10598508
申请日:2005-03-03
申请人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
发明人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
IPC分类号: A01N37/34 , A01N33/02 , A01N33/18 , A01N33/24 , A01N27/00 , A61K31/275 , A61K31/135 , A61K31/04 , A61K31/015 , C07C255/00 , C07C211/00 , C07C321/00 , C07C323/00 , C07C381/00 , C07C221/00 , C07C223/00 , C07C225/00
CPC分类号: C07C255/58 , C07C2601/02 , C07C2601/14
摘要: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的非甾体化合物,以及制备和使用这些化合物的方法。
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公开(公告)号:US20080255124A1
公开(公告)日:2008-10-16
申请号:US11576965
申请日:2005-10-13
申请人: Philip Stewart Turnbull , Andrew Lamont Larkin , Istvan Kaldor , Rodolfo Cadilla , David John Cowan , Eugene Stewart
发明人: Philip Stewart Turnbull , Andrew Lamont Larkin , Istvan Kaldor , Rodolfo Cadilla , David John Cowan , Eugene Stewart
IPC分类号: A61K31/5375 , C07C211/45 , A61K31/137 , C07D211/14 , A61K31/4453 , A61P35/00 , A61K31/4409 , C07D213/68 , C07D265/30
CPC分类号: C07C311/08 , C07C255/58 , C07C271/28 , C07C275/34 , C07C279/18 , C07C311/29 , C07C317/22 , C07C317/28 , C07C317/32 , C07C317/40 , C07C323/25 , C07C323/41 , C07C323/49 , C07C2601/02 , C07D207/27 , C07D209/08 , C07D213/38 , C07D213/53 , C07D213/64 , C07D213/69 , C07D213/73 , C07D213/75 , C07D215/227 , C07D237/14 , C07D239/34 , C07D239/42 , C07D249/08 , C07D263/32 , C07D277/22 , C07D277/24 , C07D295/088 , C07D295/13
摘要: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的非甾体化合物,以及制备和使用这些化合物的方法。
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4.
公开(公告)号:US08633175B2
公开(公告)日:2014-01-21
申请号:US12376580
申请日:2007-08-08
申请人: David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
发明人: David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
CPC分类号: C07C237/48 , A61K31/166 , A61K31/381 , A61K31/4406 , A61K31/4468 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C53/18 , C07C233/25 , C07C235/42 , C07C237/30 , C07C311/08 , C07C323/25 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D211/60 , C07D213/38 , C07D213/56 , C07D213/81 , C07D217/02 , C07D217/04 , C07D231/12 , C07D233/64 , C07D233/70 , C07D233/72 , C07D249/06 , C07D249/08 , C07D249/10 , C07D271/06 , C07D275/02 , C07D277/32 , C07D285/10 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/38 , C07D401/10 , C07D417/12
摘要: Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
摘要翻译: 作为一种或多种阿片受体的拮抗剂或反向激动剂的新型化合物,含有它们的药物组合物,其制备方法。
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5.
公开(公告)号:US20110124559A1
公开(公告)日:2011-05-26
申请号:US12376580
申请日:2007-08-08
申请人: David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
发明人: David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
IPC分类号: A61K38/18 , C07D249/08 , A61K38/22 , A61K31/4196 , A61P3/04 , A61P3/10 , A61P9/12 , A61P25/24 , A61P25/22 , A61P25/30
CPC分类号: C07C237/48 , A61K31/166 , A61K31/381 , A61K31/4406 , A61K31/4468 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C53/18 , C07C233/25 , C07C235/42 , C07C237/30 , C07C311/08 , C07C323/25 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D211/60 , C07D213/38 , C07D213/56 , C07D213/81 , C07D217/02 , C07D217/04 , C07D231/12 , C07D233/64 , C07D233/70 , C07D233/72 , C07D249/06 , C07D249/08 , C07D249/10 , C07D271/06 , C07D275/02 , C07D277/32 , C07D285/10 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/38 , C07D401/10 , C07D417/12
摘要: Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
摘要翻译: 作为一种或多种阿片受体的拮抗剂或反向激动剂的新型化合物,含有它们的药物组合物,其制备方法。
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公开(公告)号:US20090170907A1
公开(公告)日:2009-07-02
申请号:US11916694
申请日:2006-06-06
申请人: Philip Stewart Turnbull , Rodolfo Cadilla , Andrew Lamont Larkin , Eugene Lee Stewart , Katherine Stetson
发明人: Philip Stewart Turnbull , Rodolfo Cadilla , Andrew Lamont Larkin , Eugene Lee Stewart , Katherine Stetson
IPC分类号: A61K31/44 , C07C255/00 , C07D277/20 , C07D271/10 , C07D271/06 , C07D413/04 , A61K31/445 , A61K31/4245 , A61K31/41
CPC分类号: C07D307/52 , C07C211/52 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/02 , C07C2602/08 , C07D233/54 , C07D233/64 , C07D249/16 , C07D257/04 , C07D261/08 , C07D263/32 , C07D263/34 , C07D271/06 , C07D271/10 , C07D277/28 , C07D277/64 , C07D307/54 , C07D307/81 , C07D333/20 , C07D333/62 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/04
摘要: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的非甾体化合物,以及制备和使用这些化合物的方法。
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公开(公告)号:US20090163588A1
公开(公告)日:2009-06-25
申请号:US12392687
申请日:2009-02-25
申请人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
发明人: Philip Stewart Turnbull , Rodolfo Cadilla , David John Cowan , Andrew Lamont Larkin , Istvan Kaldor , Eugene Lee Stewart
IPC分类号: A61K31/24 , C07C211/52 , A61K31/136 , C07C229/40 , A61K31/196 , A61K31/165 , C07C237/20
CPC分类号: C07C255/58 , C07C2601/02 , C07C2601/14
摘要: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的非甾体化合物,以及制备和使用这些化合物的方法。
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公开(公告)号:US07939528B2
公开(公告)日:2011-05-10
申请号:US12089606
申请日:2006-10-12
申请人: Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
发明人: Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
IPC分类号: A61K31/5377 , A61K31/4184 , A61K31/416 , A61P3/00 , C07D235/04 , C07D231/56 , C07D401/02 , C07D211/06 , C07D413/02
CPC分类号: C07D235/06 , C07D231/56 , C07D235/10 , C07D401/12
摘要: The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or conditions in mammals, particularly humans. Methods of making and using such compounds are also disclosed.
摘要翻译: 本发明涉及作为阿片受体的拮抗剂或反向激动剂的新化合物。 这些化合物可用于治疗哺乳动物,特别是人中的肥胖症和相关疾病和/或病症。 还公开了制备和使用这些化合物的方法。
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9.Benzonitryl and nitrobenzyl derivatives that modulate androgen receptors 失效
标题翻译: 调节雄激素受体的苯并硝基和硝基苄基衍生物公开(公告)号:US07834063B2
公开(公告)日:2010-11-16
申请号:US11576965
申请日:2005-10-13
申请人: Philip Stewart Turnbull , Andrew Lamont Larkin , Istvan Kaldor , Rodolfo Cadilla , David John Cowan , Eugene Lee Stewart
发明人: Philip Stewart Turnbull , Andrew Lamont Larkin , Istvan Kaldor , Rodolfo Cadilla , David John Cowan , Eugene Lee Stewart
IPC分类号: A61K31/135
CPC分类号: C07C311/08 , C07C255/58 , C07C271/28 , C07C275/34 , C07C279/18 , C07C311/29 , C07C317/22 , C07C317/28 , C07C317/32 , C07C317/40 , C07C323/25 , C07C323/41 , C07C323/49 , C07C2601/02 , C07D207/27 , C07D209/08 , C07D213/38 , C07D213/53 , C07D213/64 , C07D213/69 , C07D213/73 , C07D213/75 , C07D215/227 , C07D237/14 , C07D239/34 , C07D239/42 , C07D249/08 , C07D263/32 , C07D277/22 , C07D277/24 , C07D295/088 , C07D295/13
摘要: This invention relates to benzonitryl and nitrobenzyl derivatives that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. These compounds are useful, for example, in the treatment or prophylaxis of conditions or disorders that respond to selective androgen receptor modulation.
摘要翻译: 本发明涉及作为雄激素,糖皮质激素,盐皮质激素和孕酮受体的调节剂的苯并硝基和硝基苄基衍生物,以及制备和使用这些化合物的方法。 这些化合物可用于例如治疗或预防对选择性雄激素受体调节作出反应的病症或病症。
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公开(公告)号:US20090054431A1
公开(公告)日:2009-02-26
申请号:US12089606
申请日:2006-10-12
申请人: Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
发明人: Kevin Karl Barvian , Jason Daniel Speake , David John Cowan , Andrew Lamont Larkin , Jerzy Ryszard Szewczyk
IPC分类号: A61K31/5377 , C07D235/04 , A61K31/4184 , C07D231/56 , A61K31/416 , C07D401/02 , A61P3/00 , A61P9/00 , A61P25/00 , A61K31/4439 , A61K31/47 , C07D211/06 , A61K31/454 , C07D413/02
CPC分类号: C07D235/06 , C07D231/56 , C07D235/10 , C07D401/12
摘要: The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or conditions in mammals, particularly humans. Methods of making and using such compounds are also disclosed.
摘要翻译: 本发明涉及作为阿片受体的拮抗剂或反向激动剂的新化合物。 这些化合物可用于治疗哺乳动物,特别是人中的肥胖症和相关疾病和/或病症。 还公开了制备和使用这些化合物的方法。
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