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公开(公告)号：US08865169B2
公开(公告)日：2014-10-21
申请号：US12032744
申请日：2008-02-18
IPC分类号： A61K39/395 , C07K16/44 , C07K16/12 , A61K39/00
CPC分类号： A61K39/40 , A61K39/39591 , A61K2039/505 , A61K2039/507 , C07K16/1282 , C07K16/44 , C07K2317/622 , C07K2317/76 , C07K2319/40 , Y02A50/469
摘要： The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacterial proteins, viral proteins, cancer cells, and proteins or toxins produced therefrom. In particular, the present invention includes methods and systems for binding agents that are specific to neurotoxins that cause botulism.
摘要翻译： 本发明涉及用于施用抗体治疗剂的方法和系统。 所述方法包括施用一种或多种（例如两种或三种）结合剂，其中每种结合剂具有对疾病试剂的一部分和标签的一个或多个拷贝特异的结合区。 结合剂可以是相同或不同的疾病剂的一个或多个部分特异性的。 标签与每个粘合剂相同。 所述方法包括施用抗标签抗体，其中抗标签抗体具有对标签特异性的抗标签区，并且可以具有免疫球蛋白（例如IgA，IgD，IgE，IgG和IgM）。 疾病药物包括细菌蛋白质，病毒蛋白质，癌细胞和由其产生的蛋白质或毒素。 特别地，本发明包括对导致肉毒中毒的神经毒素特异性的结合剂的方法和系统。
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公开(公告)号：US20110129474A1
公开(公告)日：2011-06-02
申请号：US12889511
申请日：2010-09-24
IPC分类号： A61K39/395 , A61P31/12 , A61P31/04 , A61P33/00 , A61P35/00 , A61P39/02 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/02 , C12N1/00
CPC分类号： A61K39/39591 , A61K2039/505 , A61K2039/507 , C07K16/1282 , C07K16/44 , C07K2317/569 , C07K2317/622 , C07K2317/76 , C07K2319/40 , Y02A50/469
摘要： The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has one or more monomers that have a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacteria, bacterial proteins, viruses, viral proteins, cancer cells, and proteins or toxins produced therefrom or from other sources such as snakes, insects, plants, etc. In particular, the present invention includes methods and systems for binding agents having one or more monomers that are specific to neurotoxins that cause botulism.
摘要翻译： 本发明涉及用于施用抗体治疗剂的方法和系统。 所述方法包括施用一种或多种（例如两种或三种）结合剂，其中每种结合剂具有一种或多种具有对疾病剂的一部分具有特异性的结合区域的单体和一种或多种 标签。 结合剂可以是相同或不同的疾病剂的一个或多个部分特异性的。 标签与每个粘合剂相同。 所述方法包括施用抗标签抗体，其中抗标签抗体具有对标签特异性的抗标签区，并且可以具有免疫球蛋白（例如IgA，IgD，IgE，IgG和IgM）。 疾病药物包括细菌，细菌蛋白质，病毒，病毒蛋白质，癌细胞，以及从其产生的蛋白质或毒素，或其他来源如蛇，昆虫，植物等。特别地，本发明包括具有 一种或多种对导致肉毒中毒的神经毒素特异的单体。
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公开(公告)号：US20100278830A1
公开(公告)日：2010-11-04
申请号：US12032744
申请日：2008-02-18
IPC分类号： A61K39/395 , A61K39/40 , C12N5/10 , C12N15/63 , A61K38/16 , C07K14/00 , A61P33/00 , A61P35/04 , A61P31/04 , A61P31/12 , A61P31/10
CPC分类号： A61K39/40 , A61K39/39591 , A61K2039/505 , A61K2039/507 , C07K16/1282 , C07K16/44 , C07K2317/622 , C07K2317/76 , C07K2319/40 , Y02A50/469
摘要： The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacterial proteins, viral proteins, cancer cells, and proteins or toxins produced therefrom. In particular, the present invention includes methods and systems for binding agents that are specific to neurotoxins that cause botulism.
摘要翻译： 本发明涉及用于施用抗体治疗剂的方法和系统。 所述方法包括施用一种或多种（例如两种或三种）结合剂，其中每种结合剂具有对疾病试剂的一部分和标签的一个或多个拷贝特异的结合区。 结合剂可以是相同或不同的疾病剂的一个或多个部分特异性的。 标签与每个粘合剂相同。 所述方法包括施用抗标签抗体，其中抗标签抗体具有对标签特异性的抗标签区，并且可以具有免疫球蛋白（例如IgA，IgD，IgE，IgG和IgM）。 疾病药物包括细菌蛋白质，病毒蛋白质，癌细胞和由其产生的蛋白质或毒素。 特别地，本发明包括对导致肉毒中毒的神经毒素特异性的结合剂的方法和系统。
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公开(公告)号：US08349326B2
公开(公告)日：2013-01-08
申请号：US12889511
申请日：2010-09-24
CPC分类号： A61K39/39591 , A61K2039/505 , A61K2039/507 , C07K16/1282 , C07K16/44 , C07K2317/569 , C07K2317/622 , C07K2317/76 , C07K2319/40 , Y02A50/469
摘要： The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has one or more monomers that have a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM). Disease agents include bacteria, bacterial proteins, viruses, viral proteins, cancer cells, and proteins or toxins produced therefrom or from other sources such as snakes, insects, plants, etc. In particular, the present invention includes methods and systems for binding agents having one or more monomers that are specific to neurotoxins that cause botulism.
摘要翻译： 本发明涉及用于施用抗体治疗剂的方法和系统。 所述方法包括施用一种或多种（例如两种或三种）结合剂，其中每种结合剂具有一种或多种具有对疾病剂的一部分具有特异性的结合区域的单体和一种或多种 标签。 结合剂可以是相同或不同的疾病剂的一个或多个部分特异性的。 标签与每个粘合剂相同。 所述方法包括施用抗标签抗体，其中抗标签抗体具有对标签特异性的抗标签区，并且可以具有免疫球蛋白（例如，IgA，IgD，IgE，IgG和IgM）。 疾病药物包括细菌，细菌蛋白质，病毒，病毒蛋白质，癌细胞，以及从其产生的蛋白质或毒素，或其他来源如蛇，昆虫，植物等。特别地，本发明包括具有 一种或多种对导致肉毒中毒的神经毒素特异的单体。
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