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公开(公告)号：US20100143434A1
公开(公告)日：2010-06-10
申请号：US12525120
申请日：2008-01-31
申请人： Pierre Schaaf , Jean-Claude Voegel
发明人： Pierre Schaaf , Jean-Claude Voegel
CPC分类号： B05D7/56 , A61K9/7007 , A61L27/34 , A61L27/54 , A61L2300/00 , A61L2420/08 , B05D7/52
摘要： The invention concerns a mechanically responsive supported polyelectrolyte multilayer film, comprising:—an elastic substrate, on which are alternately coated:—at least one exponentially growing film; and—at least one mechanically responsive barrier film. It further concerns a process for its preparation and the use of such films notably for mechanically responsive mixing or delivery of active substances. It further concerns dosage forms of a drug, biosensors and implants comprising such films.
摘要翻译： 本发明涉及一种机械响应的负载型聚电解质多层膜，其包括： - 在弹性基材上交替涂覆：至少一个指数生长膜; 和至少一个机械响应阻挡膜。 它还涉及其制备和使用这种膜的方法，特别是用于机械响应的混合或递送活性物质。 它还涉及药物，生物传感器和包含这种膜的植入物的剂型。
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公开(公告)号：US20140248324A1
公开(公告)日：2014-09-04
申请号：US14115009
申请日：2012-04-24
申请人： Laurent Jacques Grossin , Jean-Claude Voegel , Pierre Gilbert Schaaf , Pierre Gillet , Christel Odette Henrionnet , Patrick Netter
发明人： Laurent Jacques Grossin , Jean-Claude Voegel , Pierre Gilbert Schaaf , Pierre Gillet , Christel Odette Henrionnet , Patrick Netter
CPC分类号： A61L27/52 , A61L27/20 , A61L27/38 , A61L2430/24 , C08L5/04
摘要： The novel biomaterial fillers containing cross-linked sodium alginate and the method for manufacturing same are used in the medical field and are intended for filling tissue lesions having a layered structure of varying compositions, such as cartilage, skin or the epithelium. These novel biomaterials have the special feature of being multiphasic, composite and functionalized, for medical use and, in particular, for treating tissue lesions having a layered structure of varying compositions. The biomaterials are particularly suitable for treating focal lesions of the articular cartilage.
摘要翻译： 包含交联的藻酸钠的新型生物材料填料及其制造方法用于医疗领域，并且用于填充具有不同组成的层状结构的组织损伤，例如软骨，皮肤或上皮。 这些新型生物材料具有用于医疗用途的多相，复合和功能化的特殊特征，特别是用于治疗具有不同组成的分层结构的组织损伤。 生物材料特别适用于治疗关节软骨的局灶性损伤。
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3.发明申请Materials Useful for Support and/or Replacement of Tissue and the Use Thereof for Making Prostheses 审中-公开用于支持和/或替换组织的材料及其用于制作假体的材料公开(公告)号：US20090118838A1
公开(公告)日：2009-05-07
申请号：US11989941
申请日：2005-08-05
CPC分类号： A61L27/06 , A61K38/00 , A61L27/227 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/41 , A61L2300/43 , A61L2300/608 , C08L89/00
摘要： The invention relates to a material providing support and/or replacement of living tissues and the use thereof for manufacturing prostheses. The material according to the invention comprises microparticles of a biomaterial coated with polyelectrolyte multilayers containing one or more biologically active products.
摘要翻译： 本发明涉及一种提供生物体组织的支持和/或替换的材料及其用于制造假体的用途。 根据本发明的材料包括涂覆有含有一种或多种生物活性产物的聚电解质多层的生物材料的微粒。
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公开(公告)号：US20080171070A1
公开(公告)日：2008-07-17
申请号：US11883375
申请日：2006-01-31
申请人： Pierre Schaaf , Nadia Jessel , Joelle Ogier-Dirrig , Philippe Lavalle , Jean-Claude Voegel , Bernard Senger
发明人： Pierre Schaaf , Nadia Jessel , Joelle Ogier-Dirrig , Philippe Lavalle , Jean-Claude Voegel , Bernard Senger
摘要： The invention relates to polyelectrolyte multilayer films presenting a tunable biological activity and methods for preparing the same. The invention further relates to surfaces presenting such films and uses thereof, such as for the controlled delivery of biologically active agents.
摘要翻译： 本发明涉及具有可调节生物活性的聚电解质多层膜及其制备方法。 本发明还涉及呈现这种膜的表面及其用途，例如用于控制递送生物活性剂。
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5.发明申请Method for Constructing Functional Living Materials, Resulting Materials and Uses Thereof 审中-公开构建功能性生物材料的方法，结果及其用途公开(公告)号：US20090239302A1
公开(公告)日：2009-09-24
申请号：US12227216
申请日：2007-05-16
申请人： Gero Decher , Olivier Felix , Benjamin Saulnier , Albert Izquierdo , Jean-Claude Voegel , Pierre Gilbert Schaaf , Nadia Jessel , Vincent Paul Ball
发明人： Gero Decher , Olivier Felix , Benjamin Saulnier , Albert Izquierdo , Jean-Claude Voegel , Pierre Gilbert Schaaf , Nadia Jessel , Vincent Paul Ball
IPC分类号： C12N5/06
CPC分类号： A61L27/3852 , A61L27/34 , A61L27/3891
摘要： The invention concerns a method for constructing a functional living biomaterial, characterized in that it consists in assembling layer by layer (3D) a matrix and 2D layers of functional living cells by controlling their interactions and 3D structuring based on the desired organization and final shape of the biomaterial, wherein each layer has its own pattern adapted to the neighbouring layers and on the functionality of whole synthetic biomaterials. The invention is useful in the field of biomedicine and nanobiotechnology.
摘要翻译： 本发明涉及一种用于构建功能活体生物材料的方法，其特征在于，其包括通过基于期望的组织和最终形状控制它们的相互作用和3D结构来逐层（3D）组装矩阵和2D层的功能活细胞 生物材料，其中每个层具有适合于相邻层的自己的图案以及整个合成生物材料的功能性。 本发明在生物医学和纳米生物技术领域是有用的。
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公开(公告)号：US20130129907A1
公开(公告)日：2013-05-23
申请号：US13699050
申请日：2011-05-20
申请人： Gabriela Popa , Gero Decher , Fouzia Boulmedais , Olivier Felix , Pierre Schaaf , Jean-Claude Voegel , Joseph Hemmerle , Peng Zhao
发明人： Gabriela Popa , Gero Decher , Fouzia Boulmedais , Olivier Felix , Pierre Schaaf , Jean-Claude Voegel , Joseph Hemmerle , Peng Zhao
IPC分类号： B05D1/02
CPC分类号： B05D1/02 , B05D1/34 , B05D1/36 , C23C18/1204
摘要： The invention relates to a method for providing organic, semi-organic, mineral, inorganic and hybrid thin layers and thin layers containing nanoparticles, by simultaneous or alternate spraying of solutions of reactive partners (that is polymer/polymer interacting by hydrogen bonding, polyelectrolyte/small oligo-ion, inorganic compounds, etc.) on the surface of a solid substrate.
摘要翻译： 本发明涉及通过同时或替代地喷射反应性伴侣溶液（即通过氢键相互作用的聚合物/聚合物，聚电解质/聚合物）提供有机，半有机，矿物，无机和杂化薄层和含有纳米颗粒的薄层的方法， 小的寡离子，无机化合物等）在固体基质的表面上。
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7.发明申请METHOD FOR PROLIFERATION OF CELLS ON POLYELECTROLYTE MULTILAYER FILMS AND USE THEREOF, PARTICULARLY FOR THE PREPARATION OF CELLULAR BIOMATERIALS 审中-公开用于增殖聚电解质膜的细胞的方法及其用途，特别是用于制备细胞生物材料公开(公告)号：US20110151564A1
公开(公告)日：2011-06-23
申请号：US12664907
申请日：2008-06-16
申请人： Patrick Menu , Cedric Boura , Halima-Assia Kerdjoudj , Vanessa Moby , Nicolas Berthelemy , Jean-Claude Voegel , Pierre Schaaf , Jean-Francois Stoltz
发明人： Patrick Menu , Cedric Boura , Halima-Assia Kerdjoudj , Vanessa Moby , Nicolas Berthelemy , Jean-Claude Voegel , Pierre Schaaf , Jean-Francois Stoltz
IPC分类号： C12N5/07
CPC分类号： A61L27/38 , A61L27/3604 , A61L27/56
摘要： The invention relates to the use of a unit including a substrate and polyelectrolyte multilayer films deposited thereon in order to: carry out a method involving the proliferation of initial stem or differentiated cells that are brought into contact with the unit; and cover the unit with confluent viable adherent cells resulting from the proliferation of the initial cells, the cover being obtained at the end of a period of no more than one month, such as 14 days, 11 days or, in particular, 7 days, after the initial cells are brought into contact with the unit.
摘要翻译： 本发明涉及包括沉积在其上的底物和聚电解质多层膜的单元的使用，以便：执行涉及与该单元接触的初始茎或分化细胞增殖的方法; 并且由最初细胞增殖引起的汇合的活的贴壁细胞覆盖该单位，所述覆盖物在不超过一个月，例如14天，11天或特别是7天的期间结束时获得， 在初始细胞与单位接触后。
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公开(公告)号：US20070129792A1
公开(公告)日：2007-06-07
申请号：US10580544
申请日：2004-11-29
申请人： Catherine Picart , Jean-Claude Voegel , Benoit Frisch , Pierre Schaaf , Gero Decher , Frederic Cuisinier
发明人： Catherine Picart , Jean-Claude Voegel , Benoit Frisch , Pierre Schaaf , Gero Decher , Frederic Cuisinier
CPC分类号： C08J3/246 , C08J2305/08 , C08J2367/00 , C08J2389/00 , C08K5/29 , Y10T428/1334 , Y10T428/1393 , Y10T428/31551 , Y10T428/31725
摘要： The invention relates to methods for preparing crosslinked polyelectrolytes, in particular crosslinked polyelectrolytes multilayer films. The invention also relates to a method of coating a surface, and the obtained coated article.
摘要翻译： 本发明涉及制备交联聚电解质，特别是交联聚电解质多层膜的方法。 本发明还涉及涂覆表面的方法和所获得的涂覆制品。
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公开(公告)号：US09005694B2
公开(公告)日：2015-04-14
申请号：US13699050
申请日：2011-05-20
申请人： Gabriela Popa , Gero Decher , Fouzia Boulmedais , Olivier Felix , Pierre Schaaf , Jean-Claude Voegel , Joseph Hemmerle , Peng Zhao
发明人： Gabriela Popa , Gero Decher , Fouzia Boulmedais , Olivier Felix , Pierre Schaaf , Jean-Claude Voegel , Joseph Hemmerle , Peng Zhao
CPC分类号： B05D1/02 , B05D1/34 , B05D1/36 , C23C18/1204
摘要： The invention relates to a method for providing organic, semi-organic, mineral, inorganic and hybrid thin layers and thin layers containing nanoparticles, by simultaneous or alternate spraying of solutions of reactive partners (that is polymer/polymer interacting by hydrogen bonding, polyelectrolyte/small oligo-ion, inorganic compounds, etc.) on the surface of a solid substrate.
摘要翻译： 本发明涉及通过同时或替代地喷射反应性伴侣溶液（即通过氢键相互作用的聚合物/聚合物，聚电解质/聚合物）提供有机，半有机，矿物，无机和杂化薄层和含有纳米颗粒的薄层的方法， 小的寡离子，无机化合物等）在固体基质的表面上。
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公开(公告)号：US20140328883A1
公开(公告)日：2014-11-06
申请号：US14143405
申请日：2013-12-30
申请人： Catherine Picart , Jean-Claude Voegel , Benoit Frisch , Pierre Schaaf , Gero Decher , Frederic Cuisinier
发明人： Catherine Picart , Jean-Claude Voegel , Benoit Frisch , Pierre Schaaf , Gero Decher , Frederic Cuisinier
IPC分类号： C08J3/24
CPC分类号： C08J3/246 , C08J2305/08 , C08J2367/00 , C08J2389/00 , C08K5/29 , Y10T428/1334 , Y10T428/1393 , Y10T428/31551 , Y10T428/31725
摘要： The invention relates to methods for preparing crosslinked polyelectrolytes, in particular crosslinked polyelectrolytes multilayer films. The invention also relates to a method of coating a surface, and the obtained coated article.
摘要翻译： 本发明涉及制备交联聚电解质，特别是交联聚电解质多层膜的方法。 本发明还涉及涂覆表面的方法和所获得的涂覆制品。
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