-
公开(公告)号：US20100184974A1
公开(公告)日：2010-07-22
申请号：US12311122
申请日：2007-09-20
申请人： Brent Richard Stranix , Jean-Francois Lavallee , Nicolas LeBerre , Valerie Perron , Dominik Herbart , Guy Milot , Chandra Panchal
发明人： Brent Richard Stranix , Jean-Francois Lavallee , Nicolas LeBerre , Valerie Perron , Dominik Herbart , Guy Milot , Chandra Panchal
IPC分类号： C07D265/36 , C07F9/09 , C07C317/36 , C07D265/30 , C07D231/18 , C07D307/64 , C07D233/84 , C07D239/557 , C07D333/34
CPC分类号： C07C311/41 , C07C271/22 , C07C311/42 , C07C2601/14 , C07D213/56 , C07D213/82 , C07D265/36 , C07D307/79 , C07D317/62 , C07D319/18 , C07D405/12 , C07D413/12 , C07F9/06 , C07F9/091 , C07F9/58
摘要： The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3-pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO)—, R2a being selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.
摘要翻译： 本发明提供式I，IA，IB，Ib或II的HIV蛋白酶抑制剂或其药学上可接受的盐，其中R 2可以是例如2-吡啶基-CH 2 - ，3-吡啶基-CH 2 - ，4-吡啶基 -CH 2 - ，如本文所述的磺酰基，包括苯磺酰基或噻吩磺酰基，R2a-CO） - ，R2a选自胡椒基，2-吡嗪基（未取代或被H取代或者为1的烷基） 至4个碳原子）或吡啶基胺基，其中R 3可以是例如本文所述的苯基或二苯基甲基，并且其中C x可以是例如COOH，CONR 5 R 6，CH 2 OH或CH 2 OR 7。
-
公开(公告)号：US07745435B2
公开(公告)日：2010-06-29
申请号：US12176123
申请日：2008-07-18
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/497 , C07D209/14
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
-
3.发明授权Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases 有权三联环化合物，组合物和治疗癌症或病毒性疾病的方法公开(公告)号：US07425553B2
公开(公告)日：2008-09-16
申请号：US10857458
申请日：2004-05-28
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/497 , C07D209/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
4.发明授权Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents 失效二萜类化合物，其组合物及其作为抗癌剂或抗真菌剂的用途公开(公告)号：US07217844B2
公开(公告)日：2007-05-15
申请号：US10725629
申请日：2003-12-01
申请人： Pierre Beauparlant , Giorgio Attardo , Zhiying Zhang , Angela M. Stafford , Rosa Ubillas , James B. McAlpine , Jean-Francois Lavallee , Samuel Fortin , Sasmita Tripathy
发明人： Pierre Beauparlant , Giorgio Attardo , Zhiying Zhang , Angela M. Stafford , Rosa Ubillas , James B. McAlpine , Jean-Francois Lavallee , Samuel Fortin , Sasmita Tripathy
IPC分类号： C07C43/162 , C07C43/164 , C07C43/166 , C07C49/225 , C07D237/36 , C07D239/70 , A61K31/53 , A61K31/519 , A61K31/498 , A61K31/473 , A61P35/00
CPC分类号： C07C69/757 , C07C45/292 , C07C49/755 , C07C2603/26
摘要： The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.
摘要翻译： 本发明涉及二萜化合物，包含有效量的二萜化合物的组合物和可用于治疗或预防癌症或肿瘤性疾病的方法，其包括施用有效量的二萜化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，或用于诱导癌症或肿瘤细胞中的凋亡。 本发明的化合物，组合物和方法还可用于治疗或预防真菌感染。 本发明的化合物，组合物和方法也可用于抑制真菌的生长。
-
5.发明申请Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases 审中-公开三联环化合物，组合物和治疗癌症或病毒性疾病的方法公开(公告)号：US20050267073A1
公开(公告)日：2005-12-01
申请号：US11140367
申请日：2005-05-27
IPC分类号： A61K31/675 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/572 , C07F9/6558
CPC分类号： C07D491/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07F9/5728 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
公开(公告)号：US5945431A
公开(公告)日：1999-08-31
申请号：US923604
申请日：1997-09-04
申请人： Haolun Jin , Laval C. Chan , Wei Wang , Tomislav Stefanac , Tarek S. Mansour , Paul Nguyen-Ba , Jean-Francois Lavallee , Guy Falardeau
发明人： Haolun Jin , Laval C. Chan , Wei Wang , Tomislav Stefanac , Tarek S. Mansour , Paul Nguyen-Ba , Jean-Francois Lavallee , Guy Falardeau
IPC分类号： C07D215/48 , C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , C07D215/48
摘要： The present invention relates to heterocyclic compounds having antiviral activity. In particular, compounds of formula (I): wherein B, W, X, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as defined herein, are useful in the therapy and prophylaxis of cytomegalovirus (CMV) infection in mammals.
摘要翻译： 本发明涉及具有抗病毒活性的杂环化合物。 特别地，式（I）化合物：其中B，W，X，Y，R 1，R 2，R 3，R 4和n如本文所定义，可用于治疗和预防哺乳动物中巨细胞病毒（CMV）感染。
-
公开(公告)号：US08420638B2
公开(公告)日：2013-04-16
申请号：US13171891
申请日：2011-06-29
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/49 , C07D209/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
公开(公告)号：US20080318903A1
公开(公告)日：2008-12-25
申请号：US12176161
申请日：2008-07-18
申请人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence W. Doyle , Xavuer Billot
发明人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence W. Doyle , Xavuer Billot
IPC分类号： A61K31/675 , A61P35/00 , A61K31/404
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
9.发明申请公开(公告)号：US20050032802A1
公开(公告)日：2005-02-10
申请号：US10865262
申请日：2004-06-10
申请人： Jean-Francois Lavallee , Terrence Doyle , Elise Rioux , Laurent Belec , Daniel Rabouin , Xavier Billot
发明人： Jean-Francois Lavallee , Terrence Doyle , Elise Rioux , Laurent Belec , Daniel Rabouin , Xavier Billot
IPC分类号： A61K31/085 , A61K31/121 , A61K31/495 , A61K31/502 , A61K31/517 , A61P35/00 , C07C43/162 , C07C43/164 , C07C45/29 , C07C49/115 , C07C49/225 , C07C49/755 , C07C69/00 , C07C323/59 , C07F9/117 , C07D237/36 , A61K31/498
CPC分类号： C07C45/292 , C07C49/755 , C07C69/757 , C07C323/59 , C07C2603/26 , C07F9/117
摘要： The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.
-
公开(公告)号：US08410300B2
公开(公告)日：2013-04-02
申请号：US12311122
申请日：2007-09-20
申请人： Brent Richard Stranix , Jean-Francois Lavallee , Nicolas LeBerre , Valerie Perron , Dominik Herbart , Guy Milot , Chandra Panchal
发明人： Brent Richard Stranix , Jean-Francois Lavallee , Nicolas LeBerre , Valerie Perron , Dominik Herbart , Guy Milot , Chandra Panchal
IPC分类号： C07C309/32
CPC分类号： C07C311/41 , C07C271/22 , C07C311/42 , C07C2601/14 , C07D213/56 , C07D213/82 , C07D265/36 , C07D307/79 , C07D317/62 , C07D319/18 , C07D405/12 , C07D413/12 , C07F9/06 , C07F9/091 , C07F9/58
摘要： The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3 -pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO—, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.
摘要翻译： 本发明提供式I，IA，IB，Ib或II的HIV蛋白酶抑制剂或其药学上可接受的盐，其中R 2可以是例如2-吡啶基-CH 2 - ，3-吡啶基-CH 2 - ，4-吡啶基 -CH 2 - ，如本文所述的磺酰基，包括苯磺酰基或噻吩磺酰基，R2a-CO-，R2a选自胡椒基，2-吡嗪基（未取代或被H取代或由1至 4个碳原子）或吡啶甲基胺，其中R 3可以是例如本文所述的苯基或二苯基甲基，并且其中C x可以是例如COOH，CONR 5 R 6，CH 2 OH或CH 2 OR 7。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.032 秒)
